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101.
Matthew J. Osmond Melissa D. Krebs Mina B. Pantcheva 《Biotechnology and bioengineering》2020,117(10):3150-3159
Glaucoma is a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision. The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system. The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment. Thus, a biomaterial-based approach may be more appropriate for research manipulations and in vitro drug development platforms. In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment. Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin. The pore architecture of the scaffolds was altered using freeze-casting technique to make both large and small pores that were aligned or with a non-aligned random structure. The composition of the scaffolds was altered with the addition of chondroitin sulfate and/or hyaluronic acid. It was found that the hTM cells grown on large pore scaffolds proliferate more than those grown on small pores. There was an increase in the fibronectin expression with the incorporation of GAGs, and its morphology was changed by the underlying pore architecture. This work will help provide an insight into the behavior of hTM cells when introducing changes in their microenvironment. 相似文献
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The reasons why mortality is higher in the poorer areas of Britain are largely unknown. Thus how to reduce inequalities in health is a matter of conjecture. In three neighbouring towns in northern England the rates of death from all causes differ greatly. Socioeconomic conditions in the towns are similar though below average for England and Wales. The pattern of disease specific rates was analysed and related to past differences in infant mortality. It is suggested that past differences in maternal health and physique and in the postnatal environment, particularly infant feeding, housing, and overcrowding, may be determinants of current differences in adult mortality. 相似文献
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Zavafer Alonso Losciale Pasquale Öquist Gunnar He Jie Evans John R. Fitzpatrick Duncan Oguchi Riichi Fan Dayong Osmond Charles Barry Zhang Mengmeng Huang Wei McCaffery Stephanie Szabó Milán 《Photosynthesis research》2021,149(1-2):253-258
Photosynthesis Research - To finish this special issue, some friends, colleagues and students of Prof. Chow (Emeritus Professor, the Research School of Biology, the Australian National University)... 相似文献
107.
This article reports a new application of material and energy accounting techniques to characterize and quantify the relationships between material input (and the related energy flows and emissions) and the services provided (i.e., material input per service unit [MIPS]) at the neighborhood level. The case study focuses on China's small residential district (SRD). It is concluded that linking a service (in this case, residential function) enabled by a given product (neighborhood development) to the amount of materials, energy, and emissions used or produced in creating that product offers a potential way to reduce the environmental impact of that service through more efficient use of materials, enlarged service scales, and improved buying decisions. 相似文献
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Gompol Suwanpimolkul Jennifer A. Grinsdale Leah G. Jarlsberg Julie Higashi Dennis H. Osmond Philip C. Hopewell Midori Kato-Maeda 《PloS one》2014,9(12)
Setting
The impact of diabetes on tuberculosis in United States and foreign-born populations in San Francisco has not been studied.Objective
To determine the characteristics, prevalence and temporal trends of diabetes in US and foreign-born persons attending the San Francisco Tuberculosis Clinic.Design
We analyzed data from individuals seeking medical attention at the San Francisco Tuberculosis Clinic. We included patients with diagnosis of tuberculosis, latent infection, or not infected with Mycobacterium tuberculosis. We assessed the temporal trend and the characteristics of individuals with and without diabetes.Result
Between 2005 and 2012, there were 4371 (19.0%) individuals without evidence of tuberculosis infection, 17,856 (77.6%) with latent tuberculosis, and 791 (3.4%) with tuberculosis. 66% were born in the United States, China, Mexico, and the Philippines. The prevalence of diabetes was the highest among individuals with tuberculosis and increased during the study period. Patients with tuberculosis and diabetes were more likely to be male, older than 45 years and born in the Philippines. There was a disproportionate association of TB and DM relative to LTBI and DM among Filipinos in individuals older than 45 years old.Conclusions
Our data suggest that Filipinos older than 45 years old are more likely to have tuberculosis probably due to a higher prevalence of diabetes. In San Francisco, tuberculosis-screening programs in individuals with diabetes and latent tuberculosis may be beneficial in patients older than 45 years old especially from the Philippines. 相似文献110.
Jari Lahti Marius Lahti Anu-Katriina Pesonen Kati Heinonen Eero Kajantie Tom Forsén Kristian Wahlbeck Clive Osmond David J. P. Barker Johan G. Eriksson Katri R?ikk?nen 《PloS one》2014,9(1)