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31.
Odintsova N. A. Plotnikov S. V. Karpenko A. A. Eliseikina M. G. 《Russian Journal of Developmental Biology》2001,32(5):304-309
A myogenic differentiation program can be realized during the cultivation of Mytilus trossuluscells derived from larvae in premyogenic developmental stages. About 10–15% of cells in such cultures showed that they are capable of contracting actively. The shape of such cells and the high concentration of actin microfilaments indicate a similarity with smooth muscle cells. However, the pattern of contractile activity and the protein composition of these cells differ significantly from the corresponding characteristics of differentiated smooth muscle cells. The proportion between the main proteins of the thick fiber, paramyosin, and myosin in cultivated cells is far lower than in the muscles of larvae or adult molluscs. We also found that substrates with different adhesional characteristics may determine cell development towards one or the other phenotype. Cells attached to the collagen substrate, but not spread on it, had high proliferative potential; the collagen substrate, however, inhibited myogenic differentiation. 相似文献
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A A Klishov V G Gololobov Iu K Khilova G Ia Grafova I A Odintsova 《Arkhiv anatomii, gistologii i émbriologii》1991,101(9-10):5-18
This is a short review of investigations of an applied character, performed at the Department of Histology and Embryology of the Academy. Most of the investigations have been carried out as joint works with clinicians and are aimed to solve some actual tasks of practical medicine. Their main contents have been investigations on reactivity and degeneration of tissues under various experimental and clinical conditions. Some new data have been obtained concerning cellular and ultrastructural mechanisms of the wound process, scientifically grounded influences have been undertaken in order to regulate this process. The material presented has served as a base for elaboration of a number of fundamental principles of histology and first of all some new ideas on histogenesis, cellular-differon organization and reparative regeneration of tissues. Regularities of histo- and organogenesis and intertissue interrelation are the base for understanding regeneration mechanisms of organs and tissues. In what form the reparative regeneration is manifested depends on histogenesis and is specific for each tissue. To know regularities of histogenesis and peculiarities of its manifestation is necessary to understand problems of pathology, since regularities of the normal histogenesis serve as a foundation for understanding the essence of pathological processes. 相似文献
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Elena S. Odintsova Pavel S. Dmitrenok Valentina N. Buneva Georgy A. Nevinsky 《Journal of molecular recognition : JMR》2013,26(3):121-135
HIV‐infected patients possess anti‐integrase (IN) IgGs and IgMs that, after isolation by chromatography on IN‐Sepharose, unlike canonical proteases, specifically hydrolyze only IN but not many other tested proteins. Hydrolysis of intact globular IN first leads to formation of many long fragments of protein, while its long incubation with anti‐IN antibodies, especially in the case of abzymes (Abzs) with a high proteolytic activity, results in the formation of short and very short oligopeptides (OPs). To identify all sites of IgG‐mediated proteolysis corresponding to known AGDs of integrase, we have used a combination of reverse‐phase chromatography, matrix‐assisted laser desorption/ionization spectrometry, and thin‐layer chromatography to analyze the cleavage products of two 20‐mer OPs corresponding to these AGDs. Both OPs contained 9–10 mainly clustered major, medium, and minor sites of cleavage. The main superficial cleavage sites of the AGDs in the intact IN and sites of partial or deep hydrolysis of the peptides analyzed do not coincide. The active sites of anti‐IN Abzs are localized on their light chains, whereas the heavy chains are responsible for the affinity of protein substrates. Interactions of intact globular proteins with both light and heavy chains of Abzs provide high specificity of IN hydrolysis. The affinity of anti‐IN Abzs for intact integrase was ~1000‐fold higher than for the OPs. The data suggest that both OPs interact mainly with the light chains of different monoclonal Abzs of the total pool of IgGs, which possesses lower affinity for substrates; and therefore, depending on the oligopeptide sequences, their hydrolysis may be less specific and remarkably different in comparison with the cleavage of intact globular IN. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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The partitioning of limited resources commonly explains how different species can coexist within the same ecological community. In this 2010 study, the diets of three coexisting freshwater fishes (Cape galaxias Galaxias zebratus, n = 27; Cape kurper Sandelia capensis, n = 60; Breede River redfin Pseudobarbus burchelli, n = 77) were characterised and compared in three headwater streams in South Africa's Cape Fold Ecoregion using gut contents and stable isotope analyses. These data were analysed to ascertain whether the three species exploit distinct trophic niches. Both approaches provided evidence that these species occupy different trophic niches, though with some overlap. However, dietary differences among sites were not consistent and were probably influenced by site-specific factors like resource availability. Pseudobarbus burchelli had a broader niche breadth at Tierkloof Stream than the other two species, but not at Waaihoek or Tierstel Streams. Our results also suggest that P. burchelli consumed a more omnivorous diet than do the other two species, whereas S. capensis occupied a higher trophic position than the other two species and consumed vertebrates. Our findings suggest that these species occupy non-equivalent feeding niches in Cape Fold Ecoregion headwater streams, and that diet partitioning might facilitate their coexistence in these systems. 相似文献
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