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81.
Yuzuru Sanemitsu Norio Kurihara Minoru Nakajima G. E. McCasland L. F. Johnson L. C. Carey 《Bioscience, biotechnology, and biochemistry》2013,77(5):845-857
Two diastereomers of 6-bromo-1, 2, 3, 4, 5-pentachlorocyclohexane were synthesized from the dl (36/45)-diastereomer of 3, 4, 5, 6-tetrachlorocyclohexene (α-BTC) and the dl (346/5)-diastereomer (γ-BTC) by several stepwise routes. Both of these new products were shown to have the configuration of lindane by NMR studies at 300 MHz and by the synthetic routes. Three diastereomers of 6-bromo-3, 4, 5-trichlorocyclohexene were also prepared and the configurations determined partly by means of 300 MHz NMR. 相似文献
82.
Hisao Shibata Daikichi Nishimura Norio Kurihara Minoru Nakajima 《Bioscience, biotechnology, and biochemistry》2013,77(8):1002-1005
From 2,3,4,6-tetra-O-benzoyl-α-d-mannopyranosyl bromide by the Königs-Knorr reaction, α-d-mannos ides of (+)- and (?)-N-carbobenzoxy-trans-2-amino-cyclohexanol and 3-bromo-3-deoxy-1,2;4,5-di-O-isopropylidene-muco-inositol were synthesized. 相似文献
83.
Norio Kurihara Takashi Kurokawa Hiroshi Naka Minoru Nakajima 《Bioscience, biotechnology, and biochemistry》2013,77(8):1186-1969
Diacetyl-trans-aminodeoxybenzeneglycol (trans-1-acetamido-2-acetoxy-cyclohexadiene-3, 5) was synthesized by starting from α-B. T. C.-cis-diol2) through its dehydrochlorination, NaN3 treatment, reduction, and then dehalogenation with zinc. During NaN3 treatment, the formation of some diazido compounds was also observed. 相似文献
84.
Rishni Masimbula Katsunari Oki Hiroki Shibata Hisashi Osawa Norio Kondo 《Bioscience, biotechnology, and biochemistry》2013,77(9):1650-1654
ABSTRACTThe pathogenic fungi Gibberella fujikuroi and Fusarium commune produce jasmonic acid. The application of volatile deuterium-labeled methyl jasmonate increased the amount of nonlabeled JA present in G. fujikuroi and F. commune. These results indicate that the fungi have the ability to react with airborne methyl jasmonate in a manner similar to a plant. 相似文献
85.
Recent molecular phylogenetic studies reported high diversity of Ruppia species in the Mediterranean. Multiple taxa, including apparent endemics, are known from that region, however, they have thus far not been exposed to phylogenetic analyses aimed at studying their relationships to taxa from other parts of the world. Here we present a comprehensive phylogenetic analyses of the R. maritima complex using data sets composed of DNA sequences of the plastid genome, the multi-copy nuclear ITS region, and the low-copy nuclear phyB gene with a primary focus on the Mediterranean representatives of the complex. As a result, a new lineage, “Drepanensis”, was identified as the seventh entity of the complex. This lineage is endemic to the Mediterranean. The accessions included in the former “Tetraploid” entity were reclassified into two entities: an Asia–Australia–Europe disjunct “Tetraploid_α” with a paternal “Diploid” origin, and a European “Tetraploid_γ” originating from a maternal “Drepanensis” lineage. Another entity, “Tetraploid_β”, is likely to have been originated as a result of chloroplast capture through backcrossing hybridization between paternal “Tetraploid_α” and maternal “Tetraploid_γ”. Additional discovery of multiple tetraploidizations as well as hybridization and chloroplast capture at the tetraploid level indicated that hybridization has been a significant factor in the diversification of Ruppia. 相似文献
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Kazuaki Yamanaka Yoichi Kakuta Shuji Miyagawa Shigeaki Nakazawa Taigo Kato Toyofumi Abe Ryoichi Imamura Masayoshi Okumi Akira Maeda Hiroomi Okuyama Masashi Mizuno Norio Nonomura 《PloS one》2016,11(2)
Background
The association of complement with the progression of acute T cell mediated rejection (ATCMR) is not well understood. We investigated the production of complement components and the expression of complement regulatory proteins (Cregs) in acute T-cell mediated rejection using rat and human renal allografts.Methods
We prepared rat allograft and syngeneic graft models of renal transplantation. The expression of Complement components and Cregs was assessed in the rat grafts using quantitative real-time PCR (qRT-PCR) and immunofluorescent staining. We also administered anti-Crry and anti-CD59 antibodies to the rat allograft model. Further, we assessed the relationship between the expression of membrane cofactor protein (MCP) by immunohistochemical staining in human renal grafts and their clinical course.Results
qRT-PCR results showed that the expression of Cregs, CD59 and rodent-specific complement regulator complement receptor 1-related gene/protein-y (Crry), was diminished in the rat allograft model especially on day 5 after transplantation in comparison with the syngeneic model. In contrast, the expression of complement components and receptors: C3, C3a receptor, C5a receptor, Factor B, C9, C1q, was increased, but not the expression of C4 and C5, indicating a possible activation of the alternative pathway. When anti-Crry and anti-CD59 mAbs were administered to the allograft, the survival period for each group was shortened. In the human ATCMR cases, the group with higher MCP expression in the grafts showed improved serum creatinine levels after the ATCMR treatment as well as a better 5-year graft survival rate.Conclusions
We conclude that the expression of Cregs in allografts is connected with ATCMR. Our results suggest that controlling complement activation in renal grafts can be a new strategy for the treatment of ATCMR. 相似文献89.
90.
Enantiomerization of Allylic Trifluoromethyl Sulfoxides Studied by HPLC Analysis and DFT Calculations 下载免费PDF全文
Laetitia Bailly Emilie Petit Mayaka Maeno Norio Shibata Oliver Trapp Pascal Cardinael Isabelle Chataigner Dominique Cahard 《Chirality》2016,28(2):136-142
Enantiomerization of allylic trifluoromethyl sulfoxides occurs spontaneously at room temperature through the corresponding allylic trifluoromethanesulfenates via a [2,3]‐sigmatropic rearrangement. Dynamic enantioselective high‐performance liquid chromatography (HPLC) analysis revealed the stereodynamics of these sulfoxides ranging from chromatographic resolution to peak coalescence at temperatures between 5 and 53 °C. The rate constant of enantiomerization and activation parameters were determined and compared with Density Functional Theory (DFT) calculations. Chirality 28:136–142, 2016. © 2015 Wiley Periodicals, Inc. 相似文献