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91.
Nefedova Z. A. Murzina S. A. Pekkoeva S. N. Ruokolainen T. R. Veselov A. E. Efremov D. A. Nemova N. N. 《Journal of Ichthyology》2019,59(3):407-413
Journal of Ichthyology - The lipid status of juvenile Atlantic salmon Salmo salar L. at the age of 0+, 1+, 2+, and 3+ was studied in the Letnyaya Zolotitsa River (the White Sea basin) in August... 相似文献
92.
E. I. Korenberg V. V. Nefedova Yu. V. Kovalevskii Yu. V. Sorokina N. B. Gorelova 《Entomological Review》2015,95(9):1298-1307
Based on analysis of original and literature data, it is concluded that effective transmission of B. microti by the tick I. persulcatus is prevented by the following main permanent eco-parasitological factors: lack of pronounced anthropophily in the tick nymphs; low rates of spontaneous invasion of unfed adults; a short duration of the parasitic phase on humans which is not sufficient for completion of sporogony. Therefore, in spite of the possibility of sporadic cases of babesiosis, it can be stated that B. microti infection does not and will not play a significant role in infectious pathology within the vast territory where the taiga tick is the only potential source of this infection. 相似文献
93.
Molecular cloning of the DIP1 gene located in the 20A4-5 region has been performed from the following strains with the flamenco phenotype: flam SS (SS) and flam MS (MS) characterized by a high transposition rate of retrotransposon gypsy (mdg4), flam py + (P) carrying the insertion of a construction based on the P element into the region of the flamenco gene, and flamenco +. The results of restriction analysis and sequencing cloned DNA fragments has shown that strains flam SS , flam MS considerably differ from flam py + (P), and flamenco + in the structure of DIP1. Strains flam SS and flam MS have no DraI restriction site at position 1765 in the coding region of the gene, specifically, in the domain determining the signal of the nuclear localization of the DIP1 protein. This mutation has been found to consist in a nucleotide substitution in the recognition site of DraI restriction endonuclease, which is transformed from TTTAAA into TTTAAG and, hence, is not recognized by the enzyme. This substitution changes codon AAA into AAG and is translationally insignificant, because both triplets encode the same amino acid, lysine. The DIP1 gene of strains flam SS and flam MS has been found to contain a 182-bp insertion denoted IdSS (insertion in DIP1 strain SS); it is located in the second intron of the gene. The IdSS sequence is part of the open reading frame encoding the putative transposase of the mobile genetic element HB1 belonging to the Tc1/mariner family. This insertion is presumed to disturb the conformations of DNA and the chromosome, in particular, by forming loops, which alters the expression of DIP1 and, probably, neighboring genes. In strains flamenco + and flam py + (P), the IdSS insertion within the HB1 sequence is deleted. The deletion encompasses five C-terminal amino acid residues of the conserved domain and the entire C-terminal region of the putative HB1 transposase. The obtained data suggest that DIP1 is involved in the control of gypsy transpositions either directly or through interaction with other elements of the genome. 相似文献
94.
Z. A. Nefedova S. A. Murzina A. E. Veselov S. N. Pekkoeva T. R. Ruokolainen M. A. Ruch’ev N. N. Nemova 《Biology Bulletin》2017,44(1):50-54
The lipid status of juveniles of different ages (0+, 1+, 2+, and 4+) has been studied for the brown trout inhabiting the Ol’khovka and Indera rivers (the White Sea watershed area). A higher lipid status (due to particular lipid classes) has been registered for the young-of-the-year compared to older age groups; these differences were preconditioned by the quality and the quantity of the food sources. Age-dependent metabolic activity may also affect the quantitative differences, including variations in the particular groups of lipids, in juveniles of the brown trout of various ages, especially in smolts. 相似文献
95.
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97.
The region of intron 2 of the SDF1 gene encoding a chemokine of the CXC subfamily has been resequenced in Galloway, Hereford, and Black Pied cattle. Five of the single-nucleotide polymorphisms (SNPs) that were earlier detected by other authors in various breeds of cattle in North America (99C/G, 128T/C, 206C/T, 267C/G and 313C/T) have been found. The 270insC polymorphic marker has proved to be monomorphic in Russian cattle breeds. Hereford cattle significantly differ from Galloway and Black Pied cattle in the frequencies of some SNP variants and their combinations. The number of SNP combinations in Hereford and Galloway cattle exceeds that in Black Pied cattle. 相似文献
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99.
V. V. Nefedova E. I. Korenberg Yu. V. Kovalevskii M. V. Samokhvalov N. B. Gorelova 《Entomological Review》2013,93(2):258-266
The nested PCR method with primers flanking a conserved fragment of the Babesia microti ss-rDNA gene was used to examine 834 larvae of Ixodes trianguliceps ticks engorged to a varying degree, taken off 237 hosts of 12 species (rodents and insectivores). The hosts were collected in southern taiga forests in the lowmountain area of the Middle Urals (Chusovoi District, Perm Province) in 2003–2010. Babesia DNA was detected in 89 (10.7%) larvae from 8 species of small mammals. According to the data obtained by PCR and microscopic methods, either B. microti DNA or the parasites themselves were found in the blood of 45.2% of the mammals. The nucleotide sequences of 15 amplicons of Babesia DNA obtained from larvae of I. trianguliceps ticks and their hosts were identical to those of B. microti available in GenBank. In 13 cases, they were similar to B. microti US-type (a human pathogen) and in two cases (those from I. trianguliceps and from the vole Clethrionomys rufocanus from which it was removed), to B. microti of the Munich strain which is not pathogenic to humans. The duration of feeding on small mammals seems to exert the main influence on the infection rate of I. trianguliceps larvae. The fully engorged larvae contained B. microti DNA more often and usually in greater amounts than those collected during the first days of blood-sucking. The latter usually revealed Babesia DNA in the minimum quantity (< 0.064 ng/μl). According to the data obtained, transovarial transmission of Babesia in I. trianguliceps is unlikely. The processes of horizontal and transstadial transmission appear to be of crucial importance for the functioning of the natural foci of babesiosis. 相似文献
100.
Victoria V. Nefedova Maria V. Sudnitsyna Sergei V. Strelkov Nikolai B. Gusev 《Archives of biochemistry and biophysics》2013
Some properties of G84R and L99M mutants of HspB1 associated with peripheral distal neuropathies were investigated. Homooligomers formed by these mutants are larger than those of the wild type HspB1. Large oligomers of G84R and L99M mutants have compromised stability and tend to dissociate at low protein concentration. G84R and L99M mutations promote phosphorylation-dependent dissociation of HspB1 oligomers without affecting kinetics of HspB1 phosphorylation by MAPKAP2 kinase. Both mutants weakly interact with HspB6 forming small heterooligomers and being unable to form large heterooligomers characteristic for the wild type HspB1. G84R and L99M mutants possess lower chaperone-like activity than the wild type HspB1 with several model substrates. We suggest that G84R mutation affects mobility and accessibility of the N-terminal domain thus modifying interdimer contacts in HspB1 oligomers. The L99M mutation is located within the hydrophobic core of the α-crystallin domain close to the key R140 residue, and could affect the dimer stability. 相似文献