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991.
992.
Javad Tavakkoly Bazzaz Mahnaz Shojapoor Habibollah Nazem Parvin Amiri Hossein Fakhrzadeh Ramin Heshmat Maryam Parvizi Shirin Hasani Ranjbar Mahsa M. Amoli 《Molecular biology reports》2010,37(1):105-109
Methylenetetrahydrofolate reductase (MTHFR) polymorphism may play an important role in the pathophysiology of obesity and
diabetes accompanied by obesity due to its influence on plasma homocysteine levels. There are significant and sometimes very
strong relationship between levels of homocysteine and several multi-system diseases including CHD and CVA. To examine the
association between MTHFR gene C677T polymorphism in diabetes and obesity with serum homocysteine levels. A total of 682 subjects
were recruited in four groups (Normal, obese, diabetic and obese and diabetics). MTHFR gene C677T polymorphism was detected
using PCR-RFLP technique. Serum homocysteine levels were measured using HPLC. There was a significant increase in the mean
serum homocysteine levels in subjects carrying TT genotype (34.6 ± 26.5) compared to subjects carrying CC (15.1 ± 8) or CT
genotype (16.4 ± 7.8) (P < 0.000). We found no significant differences for MTHFR allele and genotype frequencies between different groups. Our data
have confirmed the association between serum homocysteine levels and MTHFR C677T genotype reported in other populations. 相似文献
993.
Mohammad Rahmati Behrooz Johari Mehdi Kadivar Elham Rismani Yousef Mortazavi 《Journal of cellular physiology》2020,235(6):5429-5444
994.
M. Shafiee G. Gosselin J-L. Imbach S. Eriksson G. Maury 《Nucleosides, nucleotides & nucleic acids》2013,32(4-5):717-719
Abstract We have determined the affinity of human deoxycytidine kinase with respect to new fluorescent N-methylanthraniloyl cytidine derivatives or non fluorescent enantiomeric cytidine analogues. New results regarding the enantioselectivity and the mechanism of the enzyme are presented. 相似文献
995.
Effects of Short-Term Over-supplementation of Copper in Milk on Hematology,Serum Proteins,Weight Gain,and Health in Dairy Calves 总被引:1,自引:0,他引:1
Zahra Naseri Mehrdad Mohri Mohammad R. Aslani Ali A. Alavi Tabatabaee 《Biological trace element research》2011,139(1):24-31
Thirty-six calves were used in the present study. The animals were divided equally into three groups (control, test 1, and
test 2). The three groups of calves were homogeneous for parity of dams, sex, and month of birth. From 14 days of age, in
the test 1 group copper as copper sulfate (Merck Co, Germany) was added to each meal of milk at a rate of 10 mg/kg of milk
for 14 days and in test 2 group copper as copper sulfate was added to each meal of milk at a rate of 20 mg/kg of milk for
14 days. Blood samples were taken by jugular venipuncture using disposable syringes at 14 (before Cu supplementation), 30,
60, and 80 days of age. Anticoagulated blood was used for CBC determination. Plane tubes were used for harvesting of serum
and the amounts of total serum protein, albumin, iron, and copper were measured. Calves were weighted at birth and at the
end of trial (day 80) and total gain and mean daily gain were calculated. Days of treatment for ill calves were also recorded
during experiment. Group (treatment) had no significant effect on the amounts of measured parameters except MCH values (p < 0.05) which were significantly lower in test 1 group than other trial groups. Age (sampling time) had significant effects
on the values of most measured parameters (p < 0.05) except WBC, lymphocyte, total protein, and fibrinogen. Significant interactions between sampling time and group were
not seen for any of measured parameters. No significant differences were seen for total weight gain and mean daily gain between
trial groups. Chi-square test revealed no significant difference for the days of treatment between trials groups. 相似文献
996.
997.
Naseer Mohammad Ankur Dahayat Manorama Yadav Fatima Shirin S. A. Ansari 《Physiology and Molecular Biology of Plants》2018,24(4):655-663
Litsea glutinosa (Lour.), one of the most dwindling forest species in central India, is represented by highly fragmented populations that have been drastically reduced for the last 40 years, promulgating government ban on its extraction. For the first time with the help of ISSR markers, we investigated genetic variation and population structure of L. glutinosa in central Indian states. A total of 84 genotypes from 10 populations covering the entire potential pockets of the species in central India were collected. The percentage of polymorphic loci ranged from 44.79% (Rewa) to 94.79% (Marvahi) with a mean value of 70.10%. The sampled populations harbored high level of genetic diversity (mean h?=?0.294 and I?=?0.424) that was partitioned more within populations (73%) than between populations (27%). Bayesian structure analysis revealed the existence of four admixed genetic pools in L. glutinosa. The unsustainable extraction rather than genetic factor seems to be responsible for population fragmentation and dwindling status of this species. The dioecious nature of the species advocates an in-situ conservation to be the most suited approach for which Chhindwara, Jagdalpur, Balaghat and Jabalpur populations are appropriate. 相似文献
998.
999.
1000.
Farjam Goudarzi Adel Mohammadalipour Iraj Khodadadi Sheno Karimi Rezvan Mostoli Majid Bahabadi Mohammad Taghi Goodarzi 《Molecular biotechnology》2018,60(4):279-289
Differentiation process of mesenchymal stem cells (MSCs) into adipocyte is involved in obesity. Multiple factors such as Ca2+ play important roles in different stages of this process. Because of the complicated roles of Ca2+ in adipogenesis, the aim of present investigation was to study the influx and efflux of Ca2+ into and out of the cells during adipogenesis. Adipose-derived MSCs were used to differentiate into adipocytes. MSCs were exposed to 2.5 mM Ca2+ or 1.8 mM Ca2+ plus calcium ionophore, A23187, for 3 days. Lipid staining, triglycerides (TG) content, and glyceraldehyde phosphate dehydrogenase (GAPDH) activity were evaluated to confirm the efficiency of the differentiation. Gene expression of GLUT4, PPARγ2, RAR-α, and calreticulin, as well as the protein levels of GLUT4 and PPARγ2 were determined. Ca2+ and in particular Ca2+ plus A23187 significantly lowered the efficiency of differentiation accompanied by decrease in intracellular TG deposits, GAPDH activity and alleviation of gene, and protein levels of GLUT4 and PPARγ2. While calreticulin and RAR-α were remarkably upregulated in A23187 group. This study showed the inhibitory effects of calcium in adipogenesis. Additionally, it indicated the greater inhibitory effect of calreticulin and RAR-α in controlling adipogenesis by higher levels of calcium. 相似文献