全文获取类型
收费全文 | 2373篇 |
免费 | 122篇 |
国内免费 | 2篇 |
出版年
2023年 | 25篇 |
2022年 | 54篇 |
2021年 | 145篇 |
2020年 | 118篇 |
2019年 | 143篇 |
2018年 | 108篇 |
2017年 | 71篇 |
2016年 | 103篇 |
2015年 | 133篇 |
2014年 | 147篇 |
2013年 | 210篇 |
2012年 | 190篇 |
2011年 | 185篇 |
2010年 | 86篇 |
2009年 | 83篇 |
2008年 | 95篇 |
2007年 | 84篇 |
2006年 | 82篇 |
2005年 | 67篇 |
2004年 | 47篇 |
2003年 | 50篇 |
2002年 | 30篇 |
2001年 | 13篇 |
2000年 | 15篇 |
1999年 | 13篇 |
1998年 | 13篇 |
1997年 | 12篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1994年 | 12篇 |
1993年 | 5篇 |
1992年 | 7篇 |
1991年 | 10篇 |
1990年 | 11篇 |
1989年 | 4篇 |
1988年 | 8篇 |
1987年 | 8篇 |
1986年 | 9篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1983年 | 4篇 |
1982年 | 8篇 |
1981年 | 5篇 |
1980年 | 10篇 |
1979年 | 12篇 |
1977年 | 6篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1974年 | 7篇 |
1972年 | 5篇 |
排序方式: 共有2497条查询结果,搜索用时 15 毫秒
31.
32.
Arash Salmaninejad Saeed Farajzadeh Valilou Arezoo Gowhari Shabgah Saeed Aslani Malihe Alimardani Alireza Pasdar Amirhossein Sahebkar 《Journal of cellular physiology》2019,234(10):16824-16837
Over the course of past few years, cancer immunotherapy has been accompanied with promising results. However, preliminary investigations with respect to immunotherapy concentrated mostly on targeting the immune checkpoints, nowadays, emerge as the most efficient strategy to raise beneficial antitumor immune responses. Programmed cell death protein 1 (PD-1) plays an important role in subsiding immune responses and promoting self-tolerance through suppressing the activity of T cells and promoting differentiation of regulatory T cells. PD-1 is considered as an immune checkpoint and protects against autoimmune responses through both induction of apoptosis in antigen-specific T cells and inhibiting apoptosis in regulatory T cells. Several clinical trials exerting PD-1 monoclonal antibodies as well as other immune-checkpoint blockades have had prosperous outcomes and opened new horizons in tumor immunotherapy. Nonetheless, a bulk of patients have failed to respond to these newly emerging immune-based approach and the survival rate was not satisfying. Additional strategies, especially combination therapies, has been initiated and been further promising. Attempts to identify novel and well-suited predictive biomarkers are also sensed. In this review, the promotion of cancer immunotherapy targeting PD-1 immunoinhibitory pathway is discussed. 相似文献
33.
In vitro improvement of quail primordial germ cell expansion through activation of TGF‐beta signaling pathway 下载免费PDF全文
34.
35.
Mohamad Kanouh Marie‐Stéphane Tixier Mireille Okassa Serge Kreiter 《Zoologica scripta》2010,39(5):450-461
Kanouh, M., Tixier, M.‐S., Okassa, M. & Kreiter, S. (2010). Phylogenetic and biogeographic analysis of the genus Phytoseiulus (Acari: Phytoseiidae) —Zoologica Scripta, 39, 450–461. The taxonomy of the genus Phytoseiulus (sub‐family Amblyseiinae), has a tumultuous and confused history. This genus currently contains four species, but in previous revisions it contained five, sometimes grouped in two genera. There are no thorough phylogenetic analyses available for the group, analyses against which taxonomic and evolutionary hypotheses could be tested. The present study aims to apply morphological and molecular data to determine phylogenetic relationships among the four species presently included in this genus plus Afroseiulus robertsi, which was previously included in this genus. The new analyses show that the species of the genus Phytoseiulus do not constitute a monophyletic group. A delineation between (i) P. macropilis, P. persimilis, P. fragariae and (ii) P. longipes and A. robertsi is observed. Biogeographic data sets showed that the Neotropical and Afrotropical regions contain the highest diversity of species of Phytoseiulus and of their host plants. Consequently, the western part of Gondwana is hypothesized to be the probable centre of origin for this taxon. 相似文献
36.
Nazemian Maryam Hojati Vida Zavareh Saeed Madanchi Hamid Hashemi-Moghaddam Hamid 《International journal of peptide research and therapeutics》2020,26(1):259-269
International Journal of Peptide Research and Therapeutics - Chemotherapy using drug delivery systems can target tumor cells selectively and do not affect normal cells. In this paper, a specific... 相似文献
37.
Omid Haghighi Soheila Davaeifar Hossein Shahbani Zahiri Hadi Maleki Kambiz Akbari Noghabi 《International journal of peptide research and therapeutics》2020,26(2):783-793
Glutamate dehydrogenase (GDH), which is present in most bacteria and eukaryotes’ mitochondria, plays an important role in amino acid metabolism. In g 相似文献
38.
Mir Hadi Jazayeri Maryam Sadri Ali Mostafaie Reza Nedaeinia 《International journal of peptide research and therapeutics》2020,26(3):1251-1257
Kidney failure is one of the most important challenges in medicine. In this study, we used HEK-293 kidney cells to evaluate and compare changes in the expr 相似文献
39.
Pirkhezranian Zana Tanhaeian Abbas Mirzaii Mehdi Sekhavati Mohammad Hadi 《International journal of peptide research and therapeutics》2020,26(3):1503-1512
International Journal of Peptide Research and Therapeutics - Cancer remains one of the leading causes of death worldwide. Introduction of natural compounds with anticancer properties can be an... 相似文献
40.
Abarghooi Kahaki Fatemeh Monzavi Sakineh Bamehr Hadi Bandani Eshagh Payandeh Zahra Jahangiri Abolfazl Khalili Saeed 《International journal of peptide research and therapeutics》2020,26(4):2077-2087
International Journal of Peptide Research and Therapeutics - Membrane proteins play important functions, such as cellular communication and transferring materials in the cell. Many membrane... 相似文献