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排序方式: 共有215条查询结果,搜索用时 0 毫秒
211.
Hideaki Kabuto Masao Amakawa Mitsumasa Mankura Tomoko T. Yamanushi Akitane Mori 《Neurochemical research》2009,34(7):1299-1303
Superoxide and hydroxyl radicals are implicated in the pathogenesis of Parkinson disease, and induction of lipid peroxidation
is an important factor in progression of this disease. Docosahexaenoic acid (DHA) is a key component of the cell membrane,
and its peroxidation is inducible due to the double-bond chemical structure. However, DHA has neuroprotective effects. In
this study, we examined the effects of intraperitoneal injection (ipi) of DHA ethyl ester (DHA-Et) on 6-hydroxydopamine (6-OHDA)-induced
dopamine (DA) reduction in the mouse striatum. DHA-Et ipi for 7 days before and 7 days after a single intracerebroventricular
injection of 6-OHDA enhanced 6-OHDA-induced reduction of striatal DA level. On the other hand, ipi of DHA-Et for 7 days increased
its concentration in the striatum. Co-injection of DHA-Et and 6-OHDA increased the levels of thiobarbituric acid-reactive
substances (a marker of lipid peroxidation) in the striatum. Our results suggest that DHA-Et enhances 6-OHDA-induced DA depression
by increasing lipid peroxidation, and that excessive use of DHA-Et may increase the susceptibility of Parkinson disease in
animal model. 相似文献
212.
213.
Tsukasa Maruoka Yasuhiko Nikaido Satoshi Miyahara Eisuke Katafuchi Yoshinori Inamasu Midori Ogawa Kazumasa Fukuda Toshiyuki Nakayama Takafumi Horishita Mitsumasa Saito 《PLoS neglected tropical diseases》2021,15(6)
BackgroundLeptospirosis has been described as a biphasic disease consisting of hematogenous dissemination to major organs in the acute phase and asymptomatic renal colonization in the chronic phase. Several observational studies have suggested an association between leptospirosis and chronic kidney disease (CKD). We investigated the dynamics of leptospires and histopathological changes in the kidney to understand the relationship between them, and also investigated the extent of renal dysfunction in the acute and chronic phases of leptospirosis using a hamster model.FindingsHamsters (n = 68) were subcutaneously infected with 1 × 104 cells of the Leptospira interrogans serovar Manilae strain UP-MMC-SM. A total of 53 infected hamsters developed fatal acute leptospirosis, and the remaining 15 hamsters recovered from the acute phase, 13 of which showed Leptospira colonization in the kidneys in the chronic phase. Five asymptomatic hamsters also had renal colonization in the chronic phase. Immunofluorescence staining showed that leptospires were locally distributed in the renal interstitium in the early acute phase and then spread continuously into the surrounding interstitium. The kidneys of the surviving hamsters in the chronic phase showed patchy lesions of atrophic tubules, a finding of chronic tubulointerstitial nephritis, which were substantially consistent with the distribution of leptospires in the renal interstitium. The degree of atrophic tubules in kidney sections correlated statistically with the serum creatinine level in the chronic phase (rs = 0.78, p = 0.01).ConclusionSubcutaneous infection with pathogenic leptospires could cause acute death or chronic leptospirosis in hamsters after surviving the acute phase. We suggest that the renal distribution of leptospires during the acute phase probably affected the extent of tubular atrophy, leading to CKD. 相似文献
214.
Antibiotic resistance in pathogenic and producing bacteria, with special reference to beta-lactam antibiotics. 总被引:14,自引:0,他引:14 下载免费PDF全文
H Ogawara 《Microbiological reviews》1981,45(4):591-619
215.
Improved phage vector system in Streptomyces 总被引:1,自引:0,他引:1
A phage vector system was established by use of R4 phage in Streptomyces. Increased transfection frequency, introduction of a single BamHI site as a possible cloning site, and simple and rapid methods for isolation of phage DNA were achieved for the establishment. 相似文献