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421.
L. A. Fonina A. A. Az’muko V. N. Kalikhevich M. L. Lewit Z. A. Ardemasova S. A. Gur’yanov R. G. Belevskaya M. A. Efremov E. M. Treshchalina A. A. Mikhailova 《Russian Journal of Bioorganic Chemistry》2008,34(4):404-408
The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and its analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The iological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60–84% inhibition of growth of the following mouse cancers: lymphatic leukemia P388, melanoma B-16, and cervical carcinoma CUC-5. These peptides also restored functional activity of T-lymphocytes that was inhibited by metabolic products of the HL-60 leukemic cell line. MP-5-Lys(Ftc) was shown to preserve the functional properties of MP-5 towards T-lymphocytes, but Ftc-MP-5 was practically inactive. 相似文献
422.
Minimum of the osmotic pressure in the intestine of the cod corresponds to the osmotic pressure of sea water of 10%. The sorbtion level of neutral red by intact E. gadi remained practically unchanged after their maintenance in sea water of 8-10 to 30% during 24 hours (ecological optimum). Specimens of E. gadi transferred from 10 to 4% displayed compensatory recovery of the normal sorbtion level of the dye by the 5th-6th day of the experiment. The ability of Acanthocephala possessing extreme eutelia to a physiological adaptation is indicative of its not obligatory participation of mitotic processes in the acclimation. 相似文献
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We studied changes in the motor asymmetry of the goldfish induced by single-session long-lasting vestibular stimulations (clockwise
and counter clockwise rotations around the rostro-caudal body axis) and repetitive everyday short sessions of such stimulation
(training); the latter mode led to the development of adaptation (resistance to fatigue). Rotational stimulation of different
durations and directions elicited effects of different patterns and intensities. Such stimulation enhanced or, vice versa, smoothed the motor asymmetry in “dextral” and “ sinistral” fishes, up to full symmetry or even a change of the preferred
turning direction. Adaptation to unilateral rotational stimulation allows an experimenter to selectively and gradually induce
the resistivity of the left-or right-ward asymmetry to fatigue effects. Earlier, we found that the motor asymmetry in the
goldfish, which is determined by the functional asymmetry of the brain, correlates with the morphological asymmetry of Mauthner
neurons localized in the medulla in a mirror manner and playing a crucial role in the control of turnings in the course of
locomotion (swimming). Experimental rotational stimulation-induced gradual modification of the motor asymmetry in the goldfish
can serve as a physiological model for more detailed studies of the structural base of the functional brain asymmetry and
some mechanisms of adaptation on the level of single neurons.
Neirofiziologiya/Neurophysiology, Vol. 37, Nos. 5/6, pp. 432–442, September–December, 2005. 相似文献
425.
Industrial biotechnology employs the controlled use of microorganisms for the production of synthetic chemicals or simple
biomass that can further be used in a diverse array of applications that span the pharmaceutical, chemical and nutraceutical
industries. Recent advances in metagenomics and in the incorporation of entire biosynthetic pathways into Saccharomyces cerevisiae have greatly expanded both the fitness and the repertoire of biochemicals that can be synthesized from this popular microorganism.
Further, the availability of the S. cerevisiae entire genome sequence allows the application of systems biology approaches for improving its enormous biosynthetic potential.
In this review, we will describe some of the efforts on using S. cerevisiae as a cell factory for the biosynthesis of high-value natural products that belong to the families of isoprenoids, flavonoids
and long chain polyunsaturated fatty acids. As natural products are increasingly becoming the center of attention of the pharmaceutical
and nutraceutical industries, the use of S. cerevisiae for their production is only expected to expand in the future, further allowing the biosynthesis of novel molecular structures
with unique properties. 相似文献
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