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91.
Hughes TV Emanuel SL O'Grady HR Connolly PJ Rugg C Fuentes-Pesquera AR Karnachi P Alexander R Middleton SA 《Bioorganic & medicinal chemistry letters》2008,18(18):5130-5133
A novel series of 7-[1H-indol-2-yl]-2,3-dihydro-isoindol-1-ones designed to be inhibitors of VEGF-R2 kinase was synthesized and found to potently inhibit VEGF-R2 and Aurora-A kinases. The structure-based design, synthesis, and initial SAR of the series are discussed. 相似文献
92.
Xu G Searle LL Hughes TV Beck AK Connolly PJ Abad MC Neeper MP Struble GT Springer BA Emanuel SL Gruninger RH Pandey N Adams M Moreno-Mazza S Fuentes-Pesquera AR Middleton SA Greenberger LM 《Bioorganic & medicinal chemistry letters》2008,18(12):3495-3499
We herein disclose a novel series of 4-aminopyrimidine-5-carbaldehyde oximes that are potent and selective inhibitors of both EGFR and ErbB-2 tyrosine kinases, with IC(50) values in the nanomolar range. Structure-activity relationship (SAR) studies elucidated a critical role for the 4-amino and C-6 arylamino moieties. The X-ray co-crystal structure of EGFR with 37 was determined and validated our design rationale. 相似文献
93.
Angela M Patterson Caroline Schmutz Scott Davis Lucy Gardner Brian A Ashton Jim Middleton 《Arthritis research & therapy》2001,4(3):209
In chronic inflammatory foci, such as the rheumatoid joint, there is enhanced recruitment of phagocytes from the blood into the tissues. Chemokines are strongly implicated in directing the migration of these cells, although little is known regarding the chemokine receptors that could mediate their chemotaxis into the joint tissue. Therefore the objective of the study was to identify chemokine binding sites on macrophages and neutrophils within the rheumatoid synovium using radiolabeled ligand binding and in situ autoradiography. Specific binding sites for CCL3 (macrophage inflammatory protein-1α), CCL5 (RANTES), CCL2 (monocyte chemoattractant protein-1) and CXCL8 (IL-8) were demonstrated on CD68+ macrophages in the subintimal and intimal layers. The number and percentage of intimal cells that bound chemokines were greater in inflamed regions compared to noninflamed regions. The intensity of intimal binding varied between chemokines with the rank order, CCL3 > CCL5 > CCL2 > CXCL8. Neutrophils throughout the synovium bound CXCL8 but did not show any signal for binding CCL2, CCL3 or CCL5. 相似文献
94.
Pichler H Baumgartner S Freudenschuss M Palme S Binder EM Krska R 《Mycotoxin Research》2001,17(2):202-205
Enzyme-linked immunosorbent assays (ELISA) proved to be a fast and simple method for the detection of mycotoxins and other undesired contaminants in food and feed. The present study is focused on the optimisation and exploitation of the egg yolk antibody technology in order to develop competitive ELISAs for the detection of mycotoxins in cereals. Due to its importance as one of the most relevant Fusarium mycotoxins, the trichothecene deoxynivalenol (DON) was selected as representative. Chickens were immunised with different protein conjugates performing varying booster intervals. The antibodies were isolated by the poly(ethylene glycol) precipitation method according to Polson. By use of these antibodies an indirect competitive ELISA was developed for the detection of DON. First investigations of naturally contaminated wheat samples showed a good correspondence with results obtained by GC-ECD when calibration in blank wheat extracts was performed. 相似文献
95.
Plant collecting spread and densities: their potential impact on biogeographical studies in Thailand 总被引:2,自引:0,他引:2
J. A. N. Parnell D. A. Simpson J. Moat D. W. Kirkup P. Chantaranothai P. C. Boyce P. Bygrave S. Dransfield M. H. P. Jebb J. Macklin C. Meade D. J. Middleton A. M. Muasya A. Prajaksood C. A. Pendry R. Pooma S. Suddee P. Wilkin 《Journal of Biogeography》2003,30(2):193-209
Aims To produce representative aggregate maps of plant collection locations in Thailand and discuss their impact on biogeographical studies in Thailand and the surrounding region. Location Thailand. Methods A representative data set comprising 6593 plant specimen records for Thailand has been assembled. The data set contains ± all known collections for fifteen representative plant families and further records for another 104. All records are localized to Changwat (province), 6441 to at least quarter degree square. Results Analysis shows that the spread of collecting activity in Thailand is markedly uneven; 20% of collections come from a single Changwat (Chiang Mai) and 53% of Changwat have fifty or fewer collections. The distribution of collections by Changwat and by quarter degree square is erratic with most squares and Changwat having few collections, both in proportionate and absolute terms. Some of the most densely forested Changwats and squares appear undercollected. Distribution maps for common, easily recognized tree species in the genus Syzygium show distributional gaps. Conclusions Thailand is defined as an undercollected country. Even within the few well‐collected quarter degree squares the spread of collecting is still poor; almost all collections being localized to one of three mountain ranges or their foothills. There are many gaps in collecting activity which make impossible a straightforward interpretation of biogeographical pattern. It is argued that targeted collecting activity is needed, that assembly of this type of data set is therefore essential and that our data set and its interpretation is a model for all countries in the region. 相似文献
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Book reviewed in this article:
From Tzintzuntan to the "Image of Limited Good": Essays in Honor of George M. Foster. M. Clark, R. Kemper , and C. Nelson .
Essays in Humanistic Anthropology: A Festschrift in Honor of David Bidney. Bruce T. Grindal and Dennis M. Warren .
Cross-Examinations. P. H. Gulliver .
Currents in Anthropology: Essays in Honor of Sol Tax. Robert Hinshaw . 相似文献
From Tzintzuntan to the "Image of Limited Good": Essays in Honor of George M. Foster. M. Clark, R. Kemper , and C. Nelson .
Essays in Humanistic Anthropology: A Festschrift in Honor of David Bidney. Bruce T. Grindal and Dennis M. Warren .
Cross-Examinations. P. H. Gulliver .
Currents in Anthropology: Essays in Honor of Sol Tax. Robert Hinshaw . 相似文献
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