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排序方式: 共有257条查询结果,搜索用时 203 毫秒
61.
Anton Montsant Andrew E. Allen Sacha Coesel Alessandra De Martino Angela Falciatore Manuela Mangogna Magali Siaut Marc Heijde Kamel Jabbari Uma Maheswari Edda Rayko Assaf Vardi Kirk E. Apt John A. Berges Anthony Chiovitti Aubrey K. Davis Kimberlee Thamatrakoln Masood Z. Hadi Todd W. Lane J. Casey Lippmeier Diego Martinez Micaela S. Parker Gregory J. Pazour Mak A. Saito Dan S. Rokhsar E. Virginia Armbrust Chris Bowler 《Journal of phycology》2007,43(3):585-604
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Micheli F Fabio RD Cavanni P Rimland JM Capelli AM Chiamulera C Corsi M Corti C Donati D Feriani A Ferraguti F Maffeis M Missio A Ratti E Paio A Pachera R Quartaroli M Reggiani A Sabbatini FM Trist DG Ugolini A Vitulli G 《Bioorganic & medicinal chemistry》2003,11(2):171-183
Metabotropic glutamate receptors (mGluRs) are an unusual family of G-protein coupled receptor (GPCR), and are characterised by a large extracellular N-terminal domain that contains the glutamate binding site. We have identified a new class of non-competitive metabotropic glutamate receptor 1 (mGluR1) antagonists, 2,4-dicarboxy-pyrroles which are endowed with nanomolar potency. They interact within the 7 transmembrane (7TM) domain of the receptor and show antinociceptive properties when tested in a number of different animal models. 相似文献
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Engh Anne L.; Funk Stephan M.; Horn Russell C. Van; Scribner Kim T.; Bruford Michael W.; Libants Scot; Szykman Micaela; Smale Laura; Holekamp Kay E. 《Behavioral ecology》2002,13(2):193-200
The purpose of this study was to document patterns of reproductiveskew among male spotted hyenas (Crocuta crocuta), a speciesin which many normal mammalian sex roles are reversed. We usedpaternity determined from 12 microsatellite markers togetherwith demographic and behavioral data collected over 10 yearsfrom a free-living population to document relationships among
reproductive success (RS), social rank, and dispersal statusof male hyenas. Our data suggest that dispersal status andlength of residence are the strongest determinants of RS. Natalmales comprise over 20% of the adult male population, yet theysire only 3% of cubs, whereas immigrants sire 97%. This reproductiveadvantage to immigrants accrues despite the fact that immigrants
are socially subordinate to all adult natal males, and it providesa compelling ultimate explanation for primary dispersal inthis species. High-ranking immigrants do not monopolize reproduction,and tenure accounts for more of the variance in male reproductivesuccess than does social rank. Immigrant male hyenas rarelyfight among themselves, so combat between rivals may be a relativelyineffectual mode of sexual selection in this species. Instead,female choice of mates appears to play an important role in
determining patterns of paternity in Crocuta. Our data supporta "limited control" model of reproductive skew in this species,in which female choice may play a more important role in limitingcontrol by dominant males than do power struggles among males. 相似文献
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Cocco MT Congiu C Onnis V Morelli M Felipo V Cauli O 《Bioorganic & medicinal chemistry》2004,12(15):4169-4177
A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect. 相似文献
68.
Ramundo-Orlando A Serafino A Schiavo R Liberti M d'Inzeo G 《Biochimica et biophysica acta》2005,1668(1):33-40
The effect of extremely low frequency and low amplitude magnetic fields on gap junctional permeability was investigated by using reconstituted connexin32 hemi channel in liposomes. Cytochrome c was loaded inside these proteoliposomes and its reduction upon addition of ascorbate in the bulk aqueous phase was adopted as the index of hemi channel permeability. The permeability rate of the hemi channels, expressed as DeltaA/min, was dependent on the incubation temperature of proteoliposomes. The effect of exposures to magnetic fields at different frequencies (7, 13 and 18 Hz) and amplitudes (50, 50 and 70 microT, respectively), and at different temperatures (16, 18 and 24 degrees C) was studied. Only the exposure of proteoliposomes to 18-Hz (B(acpeak) and B(dc)=70 microT) magnetic field for 60 min at 16+/-0.4 degrees C resulted in a significant enhancement of the hemi channel permeability from DeltaA/min=0.0007+/-0.0002 to DeltaA/min=0.0010+/-0.0001 (P=0.030). This enhancement was not found for magnetic field exposures of liposomes kept at the higher temperatures tested. Temperature appears to influence lipid bilayer arrangement in such a way as being capable to mask possible effects induced by the magnetic field. Although the observed effect was very low, it seems to confirm the applicability of our model previously proposed for the interaction of low frequency electromagnetic fields with lipid membrane. 相似文献
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María del Carmen Martínez-Ballesta Germán Bou Micaela Carvajal 《Phytochemistry Reviews》2014,13(3):573-586
Aquaporins (AQPs) are integral membrane proteins that serve as selective pores through which water and small solutes cross the plasma membranes of many human tissue and cell types. They have been identified in epithelia and endothelia involved in fluid transport, such as kidney tubules and glandular epithelia, glial cells, epidermis, and adipocytes. The pathophysiological roles of these proteins and the primary and secondary involvement of AQPs are becoming apparent in diverse clinical disorders, from diabetes insipidus to various forms of edema. The advanced understanding of aquaporin biology, from the structural determinants of channel permeability to the assignment of their physiological function in different organs, will allow the use of AQPs as targets for the therapy of a wide array of diseases. In this review, the mode of action of clinically-effective plant formulae on human AQPs-related diseases at the molecular, cellular, and organism levels is explored. The use of pharmacological plant-derived compounds as a possible strategy in the therapy of diseases related to altered water homeostasis should stimulate debate and further research objectives. 相似文献