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Extracellular Enzymic Activity of Poultry Spoilage Bacteria 总被引:7,自引:7,他引:0
The extracellular enzymic activity has been studied of 224 strains of bacteria isolated mainly at 1° from spoiling chickens and turkeys and from poultry processing plants. The isolates comprised 44 strains of pigmented Pseudomonas , 57 strains of nonpigmented Pseudomonas , 29 strains of Ps. putrefaciens , 50 strains of oxidase positive Acinetobacter and 44 strains of oxidase negative Acinetobacter. None of the strains showed any significant activity against dextrin, starch, glycogen, inulin, dextran, xylan or pectin. Proteolytic activity was found mainly amongst 2 groups of pigmented pseudo-monads, and Ps. putrefaciens. Nuclease activity was found particularly amongst strains of Ps. putrefaciens and the oxidase negative Acinetobacter strains isolated from spoiling poultry. Almost all of the strains showed lipolytic activity when tested with tributyrin and a proportion of strains could also attack chicken fat. This latter property was particularly evident amongst the nonpigmented Pseudomonas strains. 相似文献
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Surinder K. Sharma Kenneth D. Bagshawe Roger G. Melton Roger F. Sherwood 《Cell biochemistry and biophysics》1992,21(1-3):109-120
The human immune response to monoclonal antibody-enzyme conjugates has been studied in patients included in the pilot clinical
trial of ADEPT. Each patient received murine monoclonal anti-CEA antibody fragments (A5B7-F(ab')2, conjugated to bacterial
enzyme, carboxypeptidase G2 (CPG2) followed by a galactosylated monoclonal anti-CPG2 antibody (SB43), 36–48 h after the conjugate.
Some patients were also given a dose of131I-labeled conjugate (4–8 mg, 7–15 mCi) for blood clearance and gamma camera image studies. All patients studied developed
human antimouse antibodies (HAMA) and anti-CPG2 antibodies within 10 d after a single course of treatment with the conjugate.
In most cases, IgM response was detected at 7 d after the conjugate followed by the IgG response 14 d later. In one patient,
HAMA and anti-CPG2 antibodies of the IgG type could still be detected at 10 mo after treatment. Anti-CPG2 antibodies in serum
of one patient were found to inhibit CPG2 activity in vitro.
Generation of neutralizing antibodies limits the use of repeat cycles of ADEPT in patients. Use of immunosuppressive agents
may allow a useful time window for several ADEPT cycle treatments by delaying the appearance of HAMA and anti-CPG2 antibodies.
Patients given cyclosporin A before and during ADEPT are currently being studied for HAMA and anti-CPG2 response. 相似文献
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G. Melton 《BMJ (Clinical research ed.)》1943,1(4297):600-601
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