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Ziermann, J.M., Infante, C., Hanken, J. and Olsson, L. 2011. Morphology of the cranial skeleton and musculature in the obligate carnivorous tadpole of Lepidobatrachus laevis (Anura: Ceratophryidae). —Acta Zoologica (Stockholm) 00 :1–12. Lepidobatrachus laevis (Ceratophryidae: Ceratophryinae) is a bizarre frog endemic to the Chacoan desert of central South America. Its tadpole is an obligate carnivore that can catch and consume live prey nearly its own size. Morphological adaptations associated with this unique feeding mode, including the larval skull anatomy and associated cranial musculature, have only been partly described. We studied the head of Stages 26–27 larvae using gross dissection, immunohistochemistry, and standard histology. Derived features of this tadpole compared to the microphagous, herbivorous larvae of most other anurans include simplified chondrocranial cartilages and very robust jaw muscles. The mm. suspensorio‐ et quadratoangularis do not take their origin from the processus muscularis of the palatoquadrate, as in most other tadpoles, but instead originate from the corpus of the palatoquadrate caudal to this process. The jaw levators are unusually large. The tadpole of Ceratophrys, another member of the ceratophryine clade, also consumes large animal prey, but its morphology is very different. It probably has evolved independently from a generalized, mainly herbivorous tadpole similar to the larva of Chacophrys, the third ceratophryine genus. Most specialized features of the larval head of Lepidobatrachus laevis are adaptations for ‘megalophagy’—ingestion of whole, very large animal prey. 相似文献
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Veronica Lindström Eva Nordström Anna Lord Stina M. E. Tucker Xingjian Su Charlotte Sahlin Alex Kasrayan Jessica Andersson Hedvig Welander Thomas Näsström Mats Holmquist Heinrich Schell Philipp J. Kahle Hannu Kalimo Christer Möller Pär Gellerfors Lars Lannfelt Joakim Bergström Martin Ingelsson 《Journal of neurochemistry》2013,126(1):131-144
Inclusions of intraneuronal alpha‐synuclein (α‐synuclein) can be detected in brains of patients with Parkinson's disease and dementia with Lewy bodies. The aggregation of α‐synuclein is a central feature of the disease pathogenesis. Among the different α‐synuclein species, large oligomers/protofibrils have particular neurotoxic properties and should therefore be suitable as both therapeutic and diagnostic targets. Two monoclonal antibodies, mAb38F and mAb38E2, with high affinity and strong selectivity for large α‐synuclein oligomers were generated. These antibodies, which do not bind amyloid‐beta or tau, recognize Lewy body pathology in brains from patients with Parkinson's disease and dementia with Lewy bodies and detect pathology earlier in α‐synuclein transgenic mice than linear epitope antibodies. An oligomer‐selective sandwich ELISA, based on mAb38F, was set up to analyze brain extracts of the transgenic mice. The overall levels of α‐synuclein oligomers/protofibrils were found to increase with age in these mice, although the levels displayed a large interindividual variation. Upon subcellular fractionation, higher levels of α‐synuclein oligomers/protofibrils could be detected in the endoplasmic reticulum around the age when behavioral disturbances develop. In summary, our novel oligomer‐selective α‐synuclein antibodies recognize relevant pathology and should be important tools to further explore the pathogenic mechanisms in Lewy body disorders. Moreover, they could be potential candidates both for immunotherapy and as reagents in an assay to assess a potential disease biomarker. 相似文献
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Marcus Kjellander Kathrin Götz Josefine Liljeruhm Mats Boman Gunnar Johansson 《Biotechnology letters》2013,35(4):585-590
Alcohol oxidase from Pichia pastoris was immobilized on nanoporous aluminium oxide membranes by silanization and activation by carbonyldiimidazole to create a flow-through enzyme reactor. Kinetic analysis of the hydrogen peroxide generation was carried out for a number of alcohols using a subsequent reaction with horseradish peroxidase and ABTS. The activity data for the immobilized enzyme showed a general similarity with literature data in solution, and the reactor could generate 80 mmol H2O2/h per litre reactor volume. Horseradish peroxidase was immobilized by the same technique to construct bienzymatic modular reactors. These were used in both single pass mode and circulating mode. Pulsed injections of methanol resulted in a linear relation between response and concentration, allowing quantitative concentration measurement. The immobilized alcohol oxidase retained 58 % of initial activity after 3 weeks of storage and repeated use. 相似文献
997.
Robert W. Henderson Mats Höggren William W. Lamar Louis W. Porras 《Studies on Neotropical Fauna and Environment》2013,48(1):39-47
The arboreal boid Corallus annulatus has a disjunct distribution in tropical wet forests from extreme southeastern Guatemala to southwestern Ecuador (west of the Andes). The characters upon which subspecies (C. a. blombergi and C. a. colombianus) were described are shown to be of no diagnostic value. Based on a suite of characters (scale, pattern, osteological), Corallus a. blombergi is elevated to species status and Corallus a. colombianus is placed in the synonymy of C. annulatus. Corallus annulatus and C. blombergi are considered to be species that are genuinely uncommon, although not necessarily rare. Resumen La boa arbórea Corallus annulatus tiene una distribución alopatrica en bosques húmedos tropicales desde el extremo sudeste de Guatemala hasta el sudoeste de Ecuador (oeste de los Andes). Demostramos que los carácteres usados para describir las subespecies C. a. blombergi y C. a. colombianus no tienen valor diagnóstico. Basado en carácteres de escamas, patrones, y osteológicos, Corallus a. blombergi es elevado al nivel de especie y Corallus a. colombianus es puesto en sinonimia con C. annulatus. Corallus annulatus y Corallus blombergi son consideradas como especies no verdaderamente comunes, pero no son necesariamente raras. 相似文献
998.
Olsson M Wapstra E Schwartz T Madsen T Ujvari B Uller T 《Evolution; international journal of organic evolution》2011,65(2):574-583
A changing climate is expected to have profound effects on many aspects of ectotherm biology. We report on a decade-long study of free-ranging sand lizards (Lacerta agilis), exposed to an increasing mean mating season temperature and with known operational sex ratios. We assessed year-to-year variation in sexual selection on body size and postcopulatory sperm competition and cryptic female choice. Higher temperature was not linked to strength of sexual selection on body mass, but operational sex ratio (more males) did increase the strength of sexual selection on body size. Elevated temperature increased mating rate and number of sires per clutch with positive effects on offspring fitness. In years when the "quality" of a female's partners was more variable (in standard errors of a male sexual ornament), clutches showed less multiple paternity. This agrees with prior laboratory trials in which females exercised stronger cryptic female choice when male quality varied more. An increased number of sires contributing to within-clutch paternity decreased the risk of having malformed offspring. Ultimately, such variation may contribute to highly dynamic and shifting selection mosaics in the wild, with potential implications for the evolutionary ecology of mating systems and population responses to rapidly changing environmental conditions. 相似文献
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Jianming Yang Shaobing Xiong Jingnan Song Hongbo Wu Yihan Zeng Linyang Lu Kongchao Shen Tianyu Hao Zaifei Ma Feng Liu Chungang Duan Mats Fahlman Qinye Bao 《Liver Transplantation》2020,10(23)
2D Ruddlesden–Popper perovskites (RPPs) are emerging as potential challengers to their 3D counterpart due to superior stability and competitive efficiency. However, the fundamental questions on energetics of the 2D RPPs are not well understood. Here, the energetics at (PEA)2(MA)n?1PbnI3n+1/[6,6]‐phenyl‐C61‐butyric acid methyl ester (PCBM) interfaces with varying n values of 1, 3, 5, 40, and ∞ are systematically investigated. It is found that n–n junctions form at the 2D RPP interfaces (n = 3, 5, and 40), instead of p–n junctions in the pure 2D and 3D scenarios (n = 1 and ∞). The potential gradient across phenethylammonium iodide ligands that significantly decreases surface work function, promotes separation of the photogenerated charge carriers with electron transferring from perovskite crystal to ligand at the interface, reducing charge recombination, which contributes to the smallest energy loss and the highest open‐circuit voltage (Voc) in the perovskite solar cells (PSCs) based on the 2D RPP (n = 5)/PCBM. The mechanism is further verified by inserting a thin 2D RPP capping layer between pure 3D perovskite and PCBM in PSCs, causing the Voc to evidently increase by 94 mV. Capacitance–voltage measurements with Mott–Schottky analysis demonstrate that such Voc improvement is attributed to the enhanced potential at the interface. 相似文献