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731.
732.
Mahdi Goudarzvand Mohammad Javan Javad Mirnajafi-Zadeh Sabah Mozafari Taki Tiraihi 《Cellular and molecular neurobiology》2010,30(2):289-299
Cognitive deficits have been observed in patients with multiple sclerosis (MS) due to hippocampal insults. Antioxidant vitamins
D and E are suggested for patients suffering from neurodegenerative diseases like MS, while their mechanisms of action are
not well understood. Here, we have tried to study the effects of these vitamins on demyelination, cell death, and remyelination
of rat hippocampus following local ethidium bromide (EB) injection. Animals received 100 mg/kg vitamin E or 5 μg/kg of vitamin
D3 for 2, 7, or 28 days. The extent of demyelination, myelin staining intensity, and expression of myelin basic protein and
caspase-3 were investigated using histological and immunoblotting verification. Administration of EB alone caused demyelination,
cell death, and afterward an endogenous repair. Vitamins E and D3 reduced the EB-induced damage and increased the endogenous
remyelination of hippocampus. Although the anti-apoptotic effect of these vitamins and protection against demyelination were
predictable based on their antioxidant effect, our results indicated the positive effect of vitamins E and D3 on process of
remyelination by endogenous progenitor cells and supported their possible therapeutic effects in the context of demyelinating
diseases like MS. 相似文献
733.
Anooshe Kafash Shima Malakoutikhah Masoud Yousefi Farhad Ataei Hamid Heidari Eskandar Rastegar-Pouyani 《Zoology in the Middle East.》2018,64(1):47-54
The Gray Toad-headed Agama (Phrynocephalus scutellatus) occurs in Iran, Pakistan and Afghanistan and is represented in Iran by four distinctive genetic clades. We built distribution models for three of these clades (one clade was not included due to a low number of distribution records) using Maximum Entropy Algorithm in order to determine the contribution of ecological factors to the distribution pattern. The degree of spatial niche overlap between every pair of clades were measured using Schoener's D niche overlap metric. The results showed that at species-level climate variables (annual precipitation, annual mean temperature) were the most influential parameters determining the boundaries of the distribution in Iran. Temperature seasonality was found to be the most influential factor in the distribution of both Clade I and Clade II. However, this variable was replaced by the annual mean temperature for Clade VI. Based on the results of Schoener's D metric, Clades I and II had the lowest, and Clades II and VI the highest level of ecological niche overlap. Comparing the result of niche overlap with genetic distance between the clades, it was found that the ecologically least similar clades were those with the longer history of genetic segregation. 相似文献
734.
735.
Molecular Biology Reports - The elevated drug efflux by ABC transports has been considered the primary mechanism of drug resistance in cancer. Recently, non-coding RNAs, such as pseudogenes, have... 相似文献
736.
Docosahexaenoic acid reversed atherosclerotic changes in human endothelial cells induced by palmitic acid in vitro 下载免费PDF全文