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61.
So far the prevalent method of the identification of pneumococci in the routine diagnostic practice has included three tests: sensitivity to optoxin, solubility in biliary salts and reaction with omniserum. At present optoxin-resistant pneumococcal strains, as well as those giving dual reaction to solubility in biliary salts, occur sufficiently often thatconsiderably complicates the identification of this infective agent. We have summarized experience in the isolation of S. pneumoniae strains, resistant to optoxin and not soluble in biliary salts; in addition, the prospects of introducing the complex approach to the identification of a given culture with the use of molecular diagnostic methods into daily practice are evaluated. 相似文献
62.
L. V. Ermolina N. Yu. Martynova A. G. Zaraisky 《Russian Journal of Bioorganic Chemistry》2010,36(1):24-31
The attachment of a cell to the extracellular matrix or the surface of another cells affects not only the cell motility, but
also gene expression. In view of this, an important problem is to establish the molecular mechanisms of signal transduction
from the receptors of cell adhesion to the nucleus, in particular, to identify and investigate the protein transducers of
these signals. One of these transducers, the LIM domain protein zyxin, is predominantly localized at the sites of cell adhesion,
where it participates in the assembly of actin filaments. Owing to its location near the inner surface of the membrane, zyxin
can interact with the transmembrane receptors of some signaling cascades and affect the signal transduction from the extracellular
ligands of these receptors. Furthermore, under certain conditions, zyxin moves from the sites of cell contacts to the nucleus,
where it directly participates in the regulation of gene expression. Of particular interest is the function of zyxin as a
possible coordinator of gene expression and morphogenetic movements in embryogenesis. The published data discussed in the
present review indicate the important role of zyxin in transmitting information from the regions of cell contacts to the genetic
apparatus of the cell. 相似文献
63.
E Taslidere N Vardi H Parlakpinar A Yıldız B Taslidere MG Karaaslan 《Biotechnic & histochemistry》2013,88(7):485-495
We evaluated the effects of melatonin on acetylsalicylic acid (ASA) induced gastroduodenal and jejunal mucosal injury. We used 40 postpubertal rats divided randomly into five groups of eight animals. The control group consisted of untreated animals. The Mel group was injected intraperitoneally (i.p.) with 5 mg/kg melatonin. The ASA group was injected i.p. with 200 mg/kg ASA. The ASA + Mel group was injected i.p. with 5 mg/kg melatonin 45 min after administering 200 mg/kg ASA i.p. The Mel + ASA group was injected i.p. with 5 mg/kg melatonin 45 min before administering 200 mg/kg ASA i.p. We found no statistically significant differences in mean histopathological scores in the ASA + Mel group compared to the ASA group. ASA caused shortened villi and loss of the apical villus in the duodenum. The histopathological score was increased and villus height was decreased in the ASA group compared to untreated controls. Treatment with melatonin attenuated the histological damage. In the ASA group, occasional areas showed erosion of villi in the jejunum; however, differences in mean histopathological score in ASA group compared to the other groups were not statistically significant. Malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) activities were measured in stomach, duodenal and jejunum tissue. We found increased MDA activity in both stomach and duodenal tissues in the ASA group compared to the control group (p < 0.05). We found no statistically significant changes in MDA levels in jejunal tissue in the ASA group compared to the control group. We found no change in SOD activity in either stomach or duodenal tissues in the ASA group compared to the control group. We observed decreased SOD activity in jejunal tissue in the ASA group compared to the control group (p < 0.05). We detected no change in GSH activity in stomach, duodenal or jejunal tissues in the ASA group compared to the control group. The stomach damage was less in melatonin treated groups, but the lesions were not completely eliminated. The jejunum in the ASA group retained a nearly normal appearance. We found that melatonin exhibited some healing effects on ASA induced duodenal mucosal injury. 相似文献
64.
We hypothesize that shifts in the annual pattern of the environmental parameters may affect the phenology of the zooplankton especially in temperate and polar areas. Five species (cold-water: Calanus glacialis, warm-water: Centropages hamatus, Temora longicornis, Acartia longiremis, and Evadne nordmanni) were tested with regard to the annual pattern of the water temperature using the dataset of 50-year-long monitoring in the White Sea (1961–2010). The hydrological summer duration increased by 20 days during the last 50 years, as it has been tracked by an earlier warming up of 0–10-m water layer in spring. Calanus glacialis responded to these changes by the appearance of CI copepodites earlier in the season. We suggest that the earlier start and longer period of ice melt may cause a longer phytoplankton bloom and thus may promote better trophic conditions during the period of Calanus reproduction and its early development. In contrast to cold-water C. glacialis, the phenology and abundance of warm-water copepods have not changed significantly. Both the timings of autumn cooling and average summer temperature remained relatively stable since the beginning of observations resulting in steady conditions during the reproductive period of warm-water species. Prolongation of summer had no effect on their reproduction. 相似文献
65.
Martynova N. Yu. Parshina E. A. Eroshkin F. M. Zaraisky A. G. 《Russian Journal of Bioorganic Chemistry》2020,46(4):530-536
Russian Journal of Bioorganic Chemistry - It has been shown earlier in a study of the role of the cytoskeletal protein zyxin in cell differentiation in the primordium of the central nervous system... 相似文献
66.
The influence of different types of mental activity on the cardiovascular system was analyzed by following indexes: the heart rate (HR), the variation magnitude (VM), the amplitude of systolic wave (SWA) and the pulse wave transit time (PWTT). A registration of these indexes was conducted when the subjects solved verbal-logical and spatial mental tasks. HR was significantly greater in the spatial tasks than in the verbal-logical tasks, while SWA had an inverse relationship. The time for solving of tasks of the both types did not differ significantly. Therefore, the observed changes in autonomic indexes were not related to a difficulty of the mental tasks, but depended on the specific cognitive processes involved in the mental tasks of different types. Thus, the observed change in HR and the decrease in SWA correlating with the blood pressure rise reflect an influence of the sympathetic nervous system on the heart work during mental tasks of the verbal-logic type. The obtained results suggest that the indexes of HR and a blood pressure may also serve as supporting criteria in a development of new technologies for a determination of different types of mental operations in addition to the rhythms of the brain electrical activity. 相似文献
67.
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69.
I. L. Erokhina S. V. Okovityy A. N. Kulikov A. A. Kazachenko M. G. Martynova O. M. Moiseeva S. N. Shulenin O. I. Emelyanova 《Cell and Tissue Biology》2008,2(1):13-17
The multifunctional mast cells (MC), located in the myocardium, actively react to the pathology of a cardiovascular system. We investigated MC density in the pericardium and myocardium of rats in intact and experimental heart failure (HF) 24 h and 14, 28, and 60 days after two (at 24 h intervals) injections of Isoproterenol (IP) inducing necrosises in the myocardium. An expressiveness of HF was estimated with the help of ultrasonic scanning of the heart after 28 and 60 days after two IP injections. MC of different degrees of maturity were identified cytochemically on paraffin sections stained with Alcian blue-Safranine. The MC density in the myocardium of intact and experimental rats was relatively low, ranging from 4 to 6 cells/mm2, thus the ratio of cells of a different degrees of maturity during HF development was reliably unchanging. In the fibrous layer of pericardium, the MC density was higher than in the myocardium and, for the intact rats, it amounted 48.6 ± 13.0 cells/mm2. 24 h to 14 days after IP injections, the MC density in pericardium in contrast to intact sample increased on the average in 1.5 times (P < 0.05) at the expense of increase of density of more differentiated cells stained with Safranine, without density change of less differentiated cells stained with Alcian blue. After 28 days, the MC density in pericardium was 2 times higher than in the intact sample (P < 0.01) and, at the same time, the density of cells of a different maturity degree (P < 0.05) was considerably increased. For 60 days, the MC density and the balance of Alcian-and Safranine-positive cells did not differ reliably from the intact sample. The dynamic of behavior of the MC population of pericardium was corresponding to HF injury on functional parameters. The data obtained indicate the active reaction of MC pericardium on a dysfunction of the myocardium; it stimulates the maturation of resident MCs and the reinforcement of the population at the expense of the migration of cells from the outside, which allows us to propose an intensification of the MC secretory function. 相似文献
70.
Molecular characterization of Streptococcus pneumoniae,particularly serotype19A/ST320, which emerged in Krasnoyarsk,Russia 下载免费PDF全文
Natalya V. Bakhareva Wei‐Chun Hung Wataru Higuchi Yasuhisa Iwao Tatyana A. Yelistratova Natalya A. Ilyenkova Yelena S. Sokolovskaya Galina P. Martynova Ivan V. Reva Galina V. Reva Sergey V. Sidorenko Lee‐Jene Teng Olga V. Peryanova Alla B. Salmina Tatsuo Yamamoto 《Microbiology and immunology》2017,61(9):359-370