全文获取类型
收费全文 | 10815篇 |
免费 | 850篇 |
国内免费 | 6篇 |
出版年
2023年 | 68篇 |
2022年 | 74篇 |
2021年 | 280篇 |
2020年 | 155篇 |
2019年 | 282篇 |
2018年 | 311篇 |
2017年 | 278篇 |
2016年 | 402篇 |
2015年 | 624篇 |
2014年 | 637篇 |
2013年 | 823篇 |
2012年 | 957篇 |
2011年 | 900篇 |
2010年 | 557篇 |
2009年 | 537篇 |
2008年 | 650篇 |
2007年 | 660篇 |
2006年 | 558篇 |
2005年 | 502篇 |
2004年 | 446篇 |
2003年 | 401篇 |
2002年 | 371篇 |
2001年 | 94篇 |
2000年 | 61篇 |
1999年 | 82篇 |
1998年 | 94篇 |
1997年 | 68篇 |
1996年 | 62篇 |
1995年 | 67篇 |
1994年 | 62篇 |
1993年 | 44篇 |
1992年 | 57篇 |
1991年 | 47篇 |
1990年 | 31篇 |
1989年 | 46篇 |
1988年 | 25篇 |
1987年 | 28篇 |
1986年 | 29篇 |
1985年 | 32篇 |
1984年 | 21篇 |
1983年 | 28篇 |
1982年 | 17篇 |
1981年 | 13篇 |
1980年 | 19篇 |
1979年 | 23篇 |
1978年 | 15篇 |
1977年 | 17篇 |
1974年 | 15篇 |
1972年 | 13篇 |
1967年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
Granchi C Roy S Mottinelli M Nardini E Campinoti F Tuccinardi T Lanza M Betti L Giannaccini G Lucacchini A Martinelli A Macchia M Minutolo F 《Bioorganic & medicinal chemistry letters》2011,21(24):7331-7336
N-Hydroxyindole-2-carboxylates possessing sulfonamide-substituents at either position 5 or 6 were designed and synthesized. The inhibitory activities of these compounds against isoforms 1 and 5 of human lactate dehydrogenase were analysed, and Ki values of the most efficient inhibitors were determined by standard enzyme kinetic studies. Some of these compounds displayed state-of-the-art inhibitory potencies against isoform 5 (Ki values as low as 5.6 μM) and behaved as competitive inhibitors versus both the substrate and the cofactor. 相似文献
993.
Rondinini C Di Marco M Chiozza F Santulli G Baisero D Visconti P Hoffmann M Schipper J Stuart SN Tognelli MF Amori G Falcucci A Maiorano L Boitani L 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2011,366(1578):2633-2641
Detailed large-scale information on mammal distribution has often been lacking, hindering conservation efforts. We used the information from the 2009 IUCN Red List of Threatened Species as a baseline for developing habitat suitability models for 5027 out of 5330 known terrestrial mammal species, based on their habitat relationships. We focused on the following environmental variables: land cover, elevation and hydrological features. Models were developed at 300 m resolution and limited to within species' known geographical ranges. A subset of the models was validated using points of known species occurrence. We conducted a global, fine-scale analysis of patterns of species richness. The richness of mammal species estimated by the overlap of their suitable habitat is on average one-third less than that estimated by the overlap of their geographical ranges. The highest absolute difference is found in tropical and subtropical regions in South America, Africa and Southeast Asia that are not covered by dense forest. The proportion of suitable habitat within mammal geographical ranges correlates with the IUCN Red List category to which they have been assigned, decreasing monotonically from Least Concern to Endangered. These results demonstrate the importance of fine-resolution distribution data for the development of global conservation strategies for mammals. 相似文献
994.
Kuduk SD Di Marco CN Cofre V Ray WJ Ma L Wittmann M Seager MA Koeplinger KA Thompson CD Hartman GD Bilodeau MT 《Bioorganic & medicinal chemistry letters》2011,21(9):2769-2772
Fused aromatics such as naphthalene were identified as highly potent and CNS penetrant M1 positive allosteric modulators during an SAR study to replace the phenyl B-ring linkage. 相似文献
995.
996.
Attention is crucial for visual perception because it allows the visual system to effectively use its limited resources by selecting behaviorally and cognitively relevant stimuli from the large amount of information impinging on the eyes. Reflexive, stimulus-driven attention is essential for successful interactions with the environment because it can, for example, speed up responses to life-threatening events. It is commonly believed that exogenous attention operates in the retinotopic coordinates of the early visual system. Here, using a novel experimental paradigm [1], we show that a nonretinotopic cue improves both accuracy and reaction times in a visual search task. Furthermore, the influence of the cue is limited both in space and time, a characteristic typical of exogenous cueing. These and other recent findings show that many more aspects of vision are processed nonretinotopically than previously thought. 相似文献
997.
Spadoni G Bedini A Orlando P Lucarini S Tarzia G Mor M Rivara S Lucini V Pannacci M Scaglione F 《Bioorganic & medicinal chemistry》2011,19(16):4910-4916
We report the synthesis, binding properties and intrinsic activity at MT(1) and MT(2) melatonin receptors of new dimeric melatonin receptor ligands in which two units of the monomeric agonist N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide (1) are linked together through different anchor points. Dimerization of compound 1 through the methoxy substituent leads to a substantial improvement in selectivity for the MT(1) receptor, and to a partial agonist behavior. Compound 3a, with a trimethylene linker, was the most selective for the MT(1) subtype (112-fold selectivity) and compound 3d, characterized by a hexamethylene spacer, had the highest MT(1) binding affinity (pK(iMT1)=8.47) and 54-fold MT(1)-selectivity. Dimerization through the aniline nitrogen of 1 abolished MT(1) selectivity, leading to compounds with either a full agonist or an antagonist behavior depending on the nature of the linker. 相似文献
998.
Examples of programmed tissue response after the interaction of cells with biomaterials are a hot topic in current dental research. We propose here the use
of anodic porous alumina (APA) for the programming of cell growth in oral tissues. In particular, APA may trigger cell growth by the controlled release
of specific growth factors and/or ions. Moreover, APA may be used as a scaffold to promote generation of new tissue, due to the high interconnectivity of
pores and the high surface roughness displayed by this material. 相似文献
999.
Pandozi C Galeazzi M Lavalle C Ficili S Russo M Santini M 《Indian pacing and electrophysiology journal》2011,10(12):556-561
Radiofrequency ablation procedures inside the left atrial appendage (LAA) are likely to involve dangerous complications because of a high thrombogenic effect. Cryoablation procedures are supposed to be safer. We describe two cases of successful cryoablation procedures. Two NavX-guided cryoablations of permanent focal atrial arrhythmias arising from the LAA were performed. Left atrial reconstruction and mapping allowed the zone of the earliest atrial potential to be recorded; the entire course of the ablation catheter was monitored. The arrhythmias were successfully ablated; no thrombotic complications were observed. 相似文献
1000.
Simonet T Zaragosi LE Philippe C Lebrigand K Schouteden C Augereau A Bauwens S Ye J Santagostino M Giulotto E Magdinier F Horard B Barbry P Waldmann R Gilson E 《Cell research》2011,21(7):1028-1038
The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms involved in chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammalian telomeres as part of the shelterin complex and are essential for maintaining chromosome end stability. In this study, we combined chromatin immunoprecipitation with high-throughput sequencing to map at high sensitivity and resolution the human chromosomal sites to which TRF1 and TRF2 bind. While most of the identified sequences correspond to telomeric regions, we showed that these two proteins also bind to extratelomeric sites. The vast majority of these extratelomeric sites contains interstitial telomeric sequences (or ITSs). However, we also identified non-ITS sites, which correspond to centromeric and pericentromeric satellite DNA. Interestingly, the TRF-binding sites are often located in the proximity of genes or within introns. We propose that TRF1 and TRF2 couple the functional state of telomeres to the long-range organization of chromosomes and gene regulation networks by binding to extratelomeric sequences. 相似文献