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Bruna Muller Cardoso Tatiane Fran?a Perles de Mello Sara Negr?o Lopes Izabel Galhardo Demarchi Daniele Stefani Lopes Lera Raíssa Bocchi Pedroso Diogenes Aparício Cortez Zilda Cristiani Gazim Sandra Mara Alessi Aristides Thais Gomes Verzignassi Silveira Maria Valdrinez Campana Lonardoni 《Memórias do Instituto Oswaldo Cruz》2015,110(8):1024-1034
The herbaceous shrub Tetradenia riparia has been traditionally used
to treat inflammatory and infectious diseases. Recently, a study showed that
T. riparia essential oil (TrEO) obtained in summer has
antileishmanial effects, although these results could be influenced by seasonal
variation. This study evaluated the activity of the TrEO obtained in different
seasons against Leishmania (Leishmania) amazonensis, in vitro and in
vivo. The compounds in the TrEO were analysed by gas chromatography-mass
spectrometry; terpenoids were present and oxygenated sesquiterpenes were the majority
compounds (55.28%). The cytotoxicity and nitric oxide (NO) production were also
tested after TrEO treatment. The TrEO from all seasons showed a 50% growth inhibitory
concentration for promastigotes of about 15 ng/mL; at 30 ng/mL and 3 ng/mL, the TrEO
reduced intracellular amastigote infection, independently of season. The TrEO from
plants harvested in summer had the highest 50% cytotoxic concentration, 1,476 ng/mL
for J774.A1 macrophages, and in spring (90.94 ng/mL) for murine macrophages. NO
production did not change in samples of the TrEO from different seasons. The
antileishmanial effect in vivo consisted of a reduction of the parasite load in the
spleen. These results suggest that the TrEO has potential effects on L. (L.)
amazonensis, consonant with its traditional use to treat parasitic
diseases. 相似文献
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