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61.
N R Poulter K T Khaw B E Hopwood M Mugambi W S Peart G Rose P S Sever 《BMJ (Clinical research ed.)》1990,300(6730):967
OBJECTIVE--To demonstrate the magnitude, timing, and cause of changes in blood pressure that occur in migrants from a low blood pressure population on moving to an urban area. DESIGN--A controlled longitudinal observational study of migrants as soon after migration as possible and follow up at three, six, 12, 18, and 24 months after migration. A cohort of controls living in a rural area who were matched for age, sex, and locality were also observed at the same periods. SETTING--35 Villages on the northern shores of Lake Victoria in western Kenya and Nairobi. PARTICIPANTS--325 Members of the Luo tribe aged 15 to 34 years who had migrated to Nairobi and 267 controls living in villages. The numbers of both groups reduced during follow up such that only 63 migrants and 143 controls were followed up for two years. MAIN OUTCOME MEASURES--A medical questionnaire and three 24 hour diet histories were completed by migrants and controls. Height, weight, pulse, and blood pressure were measured. Three 12 hour overnight urine samples were collected from all participants and analysed for sodium, potassium, and creatinine concentrations. RESULTS--The mean systolic blood pressure of migrants was significantly higher than that of controls throughout the study, and the distribution of blood pressure was shifted to the right compared with controls. The mean diastolic blood pressure of the two groups diverged over time. Blood pressure differences were not due to selective migration. The migrants'' mean urinary sodium:potassium ratio was higher than that of controls (p less than 0.001) throughout, and weight and pulse rate were also higher among migrants, although differences diminished with time. CONCLUSIONS--Urinary sodium:potassium ratio, pulse rate, and weight are important predictors of increased blood pressure among migrants from a low blood pressure community and may also be implicated in the initiation of essential hypertension. 相似文献
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Laila Berg Rahmi Lale Ingrid Bakke Nigel Burroughs Svein Valla 《Microbial biotechnology》2009,2(3):379-389
66.
El?bieta Speina Lale Dawut Mohammad Hedayati ZhengMing Wang Alfred May Sybille Schwendener Pavel Janscak Deborah L. Croteau Vilhelm A. Bohr 《Nucleic acids research》2010,38(9):2904-2916
Human RECQL5 is a member of the RecQ helicase family which is implicated in genome maintenance. Five human members of the family have been identified; three of them, BLM, WRN and RECQL4 are associated with elevated cancer risk. RECQL1 and RECQL5 have not been linked to any human disorder yet; cells devoid of RECQL1 and RECQL5 display increased chromosomal instability. Here, we report the physical and functional interaction of the large isomer of RECQL5, RECQL5β, with the human flap endonuclease 1, FEN1, which plays a critical role in DNA replication, recombination and repair. RECQL5β dramatically stimulates the rate of FEN1 cleavage of flap DNA substrates. Moreover, we show that RECQL5β and FEN1 interact physically and co-localize in the nucleus in response to DNA damage. Our findings, together with the previous literature on WRN, BLM and RECQL4’s stimulation of FEN1, suggests that the ability of RecQ helicases to stimulate FEN1 may be a general feature of this class of enzymes. This could indicate a common role for the RecQ helicases in the processing of oxidative DNA damage. 相似文献
67.
Nodule initiation involves the creation of a new symplasmic field in specific root cells of medicago species 总被引:4,自引:0,他引:4 下载免费PDF全文
Complainville A Brocard L Roberts I Dax E Sever N Sauer N Kondorosi A Wolf S Oparka K Crespi M 《The Plant cell》2003,15(12):2778-2791
The organogenesis of nitrogen-fixing nodules in legume plants is initiated in specific root cortical cells and regulated by long-distance signaling and carbon allocation. Here, we explore cell-to-cell communication processes that occur during nodule initiation in Medicago species and their functional relevance using a combination of fluorescent tracers, electron microscopy, and transgenic plants. Nodule initiation induced symplasmic continuity between the phloem and nodule initials. Macromolecules such as green fluorescent protein could traffic across short or long distances from the phloem into these primordial cells. The created symplasmic field was regulated throughout nodule development. Furthermore, Medicago truncatula transgenic plants expressing a viral movement protein showed increased nodulation. Hence, the establishment of this symplasmic field may be a critical element for the control of nodule organogenesis. 相似文献
68.
The spermatheca of Plethodon cinereus is a compound tubular gland that stores sperm from mating in early spring (March–April) to oviposition in summer (June–July). The seasonal variation of sperm storage in this species has previously been studied by light and transmission electron microscopy. In this paper, sperm aggregations, interaction of sperm with the spermathecal epithelium, and spermathecal secretions are studied using scanning electron microscopy. Within spermathecal tubules, relatively small groups of sperm are aligned along their entire lengths in parallel arrays. This pattern is similar to other plethdontids with complex spermathecae. Lumina of spermathecal tubules are filled with secretory material in April prior to the arrival of sperm, and after sperm appear, a coating of secretory material persists on the apices of the spermathecal epithelium. Sperm peripheral to the central luminal mass can become embedded in the secretory matrix or pushed deeper into the spermathecal epithelium. The spermathecal secretions may serve to attract and prolong the viability of sperm, but sperm that become enmeshed in the secretions or epithelium are phagocytized. Sperm and spermathecal secretions are largely absent after ovulation and in summer months, and new secretory vacuoles are formed in fall, although mating does not occur until spring. 相似文献
69.
S. A. Sader T. Sever J. C. Smoot M. Richards 《Human ecology: an interdisciplinary journal》1994,22(3):317-332
Landsat-thematic mapper images recorded April 1986 and 1990 were obtained for northern Guatemala. The study area corresponds to a major portion of Guatemala's Maya Biosphere reserve but also includes land outside the western and southern boundary of the reserve. The normalized difference vegetation index (NDVI) was computed at each date and image differencing (subtraction) was performed. The resulting image was thresholded into three categories: regrowth, no change, and forest clearing. A 10×10 km grid system was superimposed on the image to categorize the percentage of each 100 km2 cell that changed between 1986 and 1990. Forest clearing patterns were apparent along the border areas (Mexico and Guatemala) and all along the southern portion of the study area where human populations were moving toward the Maya Biosphere borders, along existing roads. Forest clearing was negligible or absent in the roadless areas. 相似文献
70.
The analysis of hydrocarbons and fatty acids in ten fern species indicate unique differences from plants in a higher phylogenetic order. Significant concentrations of fatty acids above C20 are present. Distributions of hydrocarbons range from C15–C33 with a trend towards two maxima at C17 and C29. Homologous series of n-alkenes are present in all species. Pristane and phytane are large components representing up to 27% of the alkanes. Distinct alkane and fatty acid differences between fern families are observed while species variations within families are slight. 相似文献