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E?DimitriadisEmail author L?Robb Y-X?Liu AC?Enders H?Martin C?Stoikos E?Wallace LA?Salamonsen 《Reproductive biology and endocrinology : RB&E》2003,1(1):34
Embryo implantation, endometrial stromal cell decidualization and formation of a functional placenta are critical processes in the establishment and maintenance of pregnancy. Interleukin (IL)-11 signalling is essential for adequate decidualization in the mouse uterus and IL-11 promotes decidualization in the human. IL-11 action is mediated via binding to the specific IL-11 receptor α (IL-11Rα). The present study examined immunoreactive IL-11 and IL-11Rα in cycling rhesus monkey endometrium, at implantation sites in cynomolgus and rhesus monkeys and in human first trimester decidua and defined distinct spatial and temporal patterns. In cycling rhesus monkey endometrium, IL-11 and IL-11Rα increased in both basalis and functionalis regions during the secretory compared with the proliferative phase, with changing cellular locations in luminal and glandular epithelium and stroma. The patterns were similar overall to those previously described in human endometrium. Differences were seen in immunostaining during implantation in cynomologus and rhesus monkey. In the cynomolgus, very little staining for IL-11 or IL-11Rα was seen in syncytio- and cyto-trophoblast cells in the villi between days 12 and 150 of pregnancy although there was moderate staining in cytotrophoblast in the shell between days 12 and 17 and in subpopulations of cytotrophoblast cells invading the arteries at day 17. By contrast in the rhesus monkey between days 24 and 35 of pregnancy and in human first trimester placenta, cyto- and syncytio-trophoblast in the villi but not cytotrophoblast in the shell were positively stained. The most intense staining for both IL-11 and IL-11Rα was present within the decidua in the maternal component of implantation sites in all three primates but moderate staining was also present in maternal vascular smooth muscle and glands perivascular cells and epithelial plaques. These results are consistent with a role for IL-11 both during decidualization and placentation in primates. 相似文献
64.
Joseph M. Culp Cheryl L. Podemski Kevin J. Cash Richard B. Lowell 《Journal of Aquatic Ecosystem Stress and Recovery (Formerly Journal of Aquatic Ecosystem Health)》2000,7(4):359-360
Authors Index
Author Index, Volume 7 相似文献65.
The mitochondrial DNA (mtDNA) of individuals from 79 colonies of Apis mellifera from five Canary Islands was studied using the Dra I test based on the restriction of PCR products of the tRNAleu–COII intergenic region. Five haplotypes of the African (A) lineage and one of the west European (C) lineage were found. The haplotypes A14 and A15 are described for the first time. These haplotypes have a new P sequence named P1 . The wide distribution and high frequency of haplotype A15 suggest that it is characteristic of the Canarian Archipelago. Sources of haplotype variability of honeybee mtDNA in the Canary Islands (waves of colonization from Africa, queen importations, habitat diversification) are discussed. 相似文献
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Janaína A Couto Karina LA Saraiva Cleiton D Barros Daniel P Udrisar Christina A Peixoto Juliany SB César Vieira Maria C Lima Suely L Galdino Ivan R Pitta Maria I Wanderley 《Reproductive biology and endocrinology : RB&E》2010,8(1):13
Background
The present study was designed to examine the effect of chronic treatment with rosiglitazone - thiazolidinedione used in the treatment of type 2 diabetes mellitus for its insulin sensitizing effects - on the Leydig cell steroidogenic capacity and expression of the steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme (P450scc) in normal adult rats. 相似文献69.
Eriksson F Culp WD Massey R Egevad L Garland D Persson MA Pisa P 《Cancer immunology, immunotherapy : CII》2007,56(5):677-687
Within cancer research, phage display libraries have been widely used for the identification of tumor targeting peptides and
antibodies. Additionally, phages are known to be highly immunogenic; therefore we evaluated the immunotherapeutic potential
of tumor specific phages to treat established solid tumors in a mouse model of melanoma. We developed two tumor specific phages,
one derived from a peptide phage display library and one Fab expressing phage with known specificity, for the treatment of
mice bearing palpable B16-F10 or B16/A2Kb tumors. Therapy in B16-F10 tumor bearing mice with tumor specific phages was superior to treatment with non-tumor specific
phages and lead to delayed tumor growth and increased survival. In B16/A2Kb tumor bearing mice, therapy with tumor specific phages resulted in complete tumor regression and long-term survival in 50%
of the mice. Histological analysis of tumors undergoing treatment with tumor specific phages revealed that phage administration
induced a massive infiltration of polymorphonuclear neutrophils. Furthermore, phages induced secretion of IL-12 (p70) and
IFN-γ as measured in mouse splenocyte culture supernatants. These results demonstrate a novel, immunotherapeutic cancer treatment
showing that tumor specific phages can promote regression of established tumors by recruitment of inflammatory cells and induction
of Th1 cytokines. 相似文献
70.
Laurie W Lazott John A Ponzo Rudolph B Puana Katie S Artz David P Ciceri William C Culp Jr 《BMC anesthesiology》2007,7(1):1-5