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The aim of the study was to examine the effects of an elevated dietary cobalt supply to dairy cows on rumen fermentation parameters and microbial vitamin B12 synthesis in the rumen. Five lactating dairy cows fitted with a ruminal and a duodenal cannula were subsequently fed either a ration containing only the native cobalt content (0.17 mg Co/ kg DM) or a ration supplemented with cobalt sulphate (0.29 mg Co/kg DM). The pH-value, the ammonia concentration as well as the concentration and the molar proportions of short chain fatty acids in the rumen were not significantly influenced by feeding the ration with the higher cobalt content. While there was no difference in microbial protein flow, the cobalamin flow at the duodenum was significantly elevated in supplemented animals (3.67 +/- 0.69 vs. 8.63 +/- 2.22 mg B12/d). The efficiency of cobalt utilisation for ruminal vitamin B12 synthesis was calculated to be 7.1 +/- 1.3% for the unsupplemented and 9.5 +/- 2.4% for the supplemented ration. Further investigation has to prove if there are any benefits for cows resulting from the elevated cobalamin synthesis measured, caused by feeding higher amounts of dietary cobalt. 相似文献
994.
Hasselbalch AL Benyamin B Visscher PM Heitmann BL Kyvik KO Sørensen TI 《Obesity (Silver Spring, Md.)》2008,16(12):2723-2729
To estimate common and distinct genetic influences on a panel of obesity-related traits and serum leptin level in adults. In a cross-sectional study of 625 Danish, adult, healthy, monozygotic, and same-sex dizygotic twin pairs of both genders, we carried out detailed anthropometry (height, weight, waist and hip, and skin-fold thickness, body composition assessment by bioimpedance (fat mass and fat-free mass), and measurement of serum leptin level. Bivariate variance component analyses estimated the additive genetic correlations between these measurements. The genetic correlations between the traits for overall fatness (BMI and fat mass index, kg/m(2)) were 0.94 in men and 0.98 in women, and their correlations with the various local fatness measures ranged from 0.49 to 0.83 in men and from 0.70 to 0.87 in women. The correlations between the truncal measures (waist circumference and truncal skin folds) and between the peripheral measures (hip circumference and peripheral skin folds) were 0.57 and 0.47 in men and 0.71 and 0.70 in women, respectively. The correlations between the truncal and peripheral measures ranged between 0.49 and 0.72 in men and between 0.61 and 0.82 in women. For leptin vs. the various measures of overall and local fatness the correlations ranged from 0.54 to 0.74 in men and from 0.48 to 0.75 in women. All correlations were significantly <1.00. The study supports control of overall fat mass and peripheral and truncal fat mass by both shared and different genetic components, which suggests that it is important to distinguish between the different phenotypes in the search for genes involved in the development of obesity. 相似文献
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Schneider K Loewendorf A De Trez C Fulton J Rhode A Shumway H Ha S Patterson G Pfeffer K Nedospasov SA Ware CF Benedict CA 《Cell host & microbe》2008,3(2):67-76
Toll-like receptor (TLR)-dependent pathways control the production of IFNalphabeta, a key cytokine in innate immune control of viruses including mouse cytomegalovirus (MCMV). The lymphotoxin (LT) alphabeta-LTbeta receptor signaling pathway is also critical for defense against MCMV and thought to aid in the IFNbeta response. We find that upon MCMV infection, mice deficient for lymphotoxin (LT)alphabeta signaling cannot mount the initial part of a biphasic IFNalphabeta response, but show normal levels of IFNalphabeta during the sustained phase of infection. Significantly, the LTalphabeta-dependent, IFNalphabeta response is independent of TLR signaling. B, but not T, cells expressing LTbeta are essential for promoting the initial IFNalphabeta response. LTbetaR expression is required strictly in splenic stromal cells for initial IFNalphabeta production to MCMV and is dependent upon the NF-kappaB-inducing kinase (NIK). These results reveal a TLR-independent innate host defense strategy directed by B cells in communication with stromal cells via the LTalphabeta cytokine system. 相似文献
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A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid‐β oligomers 下载免费PDF全文
Adriano Sebollela Erika N. Cline Izolda Popova Kevin Luo Xiaoxia Sun Jay Ahn Milena A. Barcelos Vanessa N. Bezerra Natalia M. Lyra e Silva Jason Patel Nathalia R. Pinheiro Lei A. Qin Josette M. Kamel Anthea Weng Nadia DiNunno Adrian M. Bebenek Pauline T. Velasco Kirsten L. Viola Pascale N. Lacor Sergio T. Ferreira William L. Klein 《Journal of neurochemistry》2017,142(6):934-947
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Katarzyna Nowak Kirsten Wimberger Shane A. Richards Russell A. Hill Aliza le Roux 《International journal of primatology》2017,38(2):194-206
Wild species use habitats that vary in risk across space and time. This risk can derive from natural predators and also from direct and indirect human pressures. A starving forager will often take risks that a less hungry forager would not. At a highly seasonal and human-modified site, we predicted that arboreal samango monkeys (Cercopithecus albogularis labiatus) would show highly flexible, responsive, risk-sensitive foraging. We first determined how monkeys use horizontal and vertical space across seasons to evaluate if high-risk decisions (use of gardens and ground) changed with season, a proxy for starvation risk. Then, during a subsequent winter, we offered equal feeding opportunities (in the form of high-value, raw peanuts) in both gardens and forest to see if this short-term change in food availability and starvation risk affected monkeys’ foraging decisions. We found that during the food-scarce winter, monkeys foraged outside indigenous forest and in gardens, where they fed on exotic species, especially fallen acorns (Quercus spp.), despite potential threats from humans. Nevertheless, and as predicted, when given the choice of foraging on high-value foods in gardens vs. forest during our artificial foraging experiment, monkeys showed a preference for a safer forest habitat. Our experiment also indicated monkeys’ sensitivity to risk in the lower vertical strata of both habitats, despite their previous extensive use of the ground. Our findings support one of the central tenets of optimal foraging theory: that risk of starvation and sensitivity to the variation in food availability can be as important drivers of behavior as risk of predation. 相似文献
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Student obesity prevalence and behavioral outcomes for the Massachusetts Childhood Obesity Research Demonstration project 下载免费PDF全文
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Bacterial phytopathogen infection disrupts belowground plant indirect defense mediated by tritrophic cascade 下载免费PDF全文
Monique J. Rivera Kirsten S. Pelz‐Stelinski Xavier Martini Lukasz L. Stelinski 《Ecology and evolution》2017,7(13):4844-4854
Plants can defend themselves against herbivores through activation of defensive pathways and attraction of third‐trophic‐level predators and parasites. Trophic cascades that mediate interactions in the phytobiome are part of a larger dynamic including the pathogens of the plant itself, which are known to greatly influence plant defenses. As such, we investigated the impact of a phloem‐limited bacterial pathogen, Candidatus Liberibacter asiaticus (CLas), in cultivated citrus rootstock on a well‐studied belowground tritrophic interaction involving the attraction of an entomopathogenic nematode (EPN), Steinernema diaprepesi, to their root‐feeding insect hosts, Diaprepes abbreviatus larvae. Using belowground olfactometers, we show how CLas infection interferes with this belowground interaction by similarly inducing the release of a C12 terpene, pregeijerene, and disconnecting the association of the terpene with insect presence. D. abbreviatus larvae that were not feeding but in the presence of a CLas‐infected plant were more likely to be infected by EPN than those near uninfected plants. Furthermore, nonfeeding larvae associated with CLas‐infected plants were just as likely to be infected by EPN as those near noninfected plants with D. abbreviatus larval damage. Larvae of two weevil species, D. abbreviatus and Pachnaeus litus, were also more attracted to plants with infection than to uninfected plants. D. abbreviatus larvae were most active when exposed to pregeijerene at a concentration of 0.1 μg/μl. We attribute this attraction to CLas‐infected plants to the same signal previously thought to be a herbivore‐induced plant volatile specifically induced by root‐feeding insects, pregeijerene, by assessing volatiles collected from the roots of infected plants and uninfected plants with and without feeding D. abbreviatus. Synthesis. Phytopathogens can influence the structuring of soil communities extending to the third trophic level. Field populations of EPN may be less effective at host‐finding using pregeijerene as a cue in citrus grove agroecosystems with high presence of CLas infection. 相似文献