全文获取类型
收费全文 | 235篇 |
免费 | 23篇 |
出版年
2021年 | 3篇 |
2020年 | 2篇 |
2017年 | 7篇 |
2016年 | 5篇 |
2015年 | 8篇 |
2014年 | 9篇 |
2013年 | 9篇 |
2012年 | 10篇 |
2011年 | 15篇 |
2010年 | 2篇 |
2009年 | 13篇 |
2008年 | 15篇 |
2007年 | 7篇 |
2006年 | 9篇 |
2005年 | 15篇 |
2004年 | 15篇 |
2003年 | 18篇 |
2002年 | 13篇 |
2001年 | 3篇 |
1999年 | 3篇 |
1998年 | 8篇 |
1997年 | 3篇 |
1996年 | 5篇 |
1995年 | 3篇 |
1993年 | 2篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1983年 | 3篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1973年 | 4篇 |
1972年 | 2篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1968年 | 3篇 |
1956年 | 1篇 |
1952年 | 1篇 |
1949年 | 2篇 |
1938年 | 1篇 |
1937年 | 1篇 |
1936年 | 2篇 |
1934年 | 2篇 |
1926年 | 2篇 |
1924年 | 1篇 |
1890年 | 2篇 |
1888年 | 1篇 |
1887年 | 1篇 |
排序方式: 共有258条查询结果,搜索用时 15 毫秒
251.
252.
Kathleen M. Tripp John P. Verstegen Charles J. Deutsch Robert K. Bonde Martine de Wit Charles A. Manire Joseph Gaspard Kendal E. Harr 《Zoo biology》2011,30(1):17-31
The study objectives were to determine the predominant manatee glucocorticoid; validate assays to measure this glucocorticoid and adrenocorticotropic hormone (ACTH); determine diagnostic thresholds to distinguish physiological vs. pathological concentrations; identify differences associated with sex, age class, female reproductive status, capture time, and lactate; and determine the best methods for manatee biologists and clinicians to diagnose stress. Cortisol is the predominant manatee glucocorticoid. IMMULITE 1000 assays for cortisol and ACTH were validated. Precision yielded intra‐ and inter‐assay coefficients of variation for serum cortisol: ≤23.5 and ≤16.7%; and ACTH: ≤6.9 and ≤8.5%. Accuracy resulted in a mean adjusted R2≥0.87 for serum cortisol and ≥0.96 for ACTH. Assay analytical sensitivities for cortisol (0.1 µg/dl) and ACTH (10.0 pg/ml) were verified. Methods were highly correlated with another IMMULITE 1000 for serum cortisol (r=0.97) and ACTH (r=0.98). There was no significant variation in cortisol or ACTH with sex or age class and no correlation with female progesterone concentrations. Cortisol concentrations were highest in unhealthy manatees, chronically stressed by disease or injury. ACTH was greatest in healthy free‐ranging or short‐term rehabilitating individuals, peracutely stressed by capture and handling. Cortisol concentrations ≥1.0 µg/dl were diagnostic of chronic stress; ACTH concentrations ≥87.5 pg/ml were diagnostic of peracute stress. In healthy long‐term captive manatees, cortisol (0.4±0.2 µg/dl) and ACTH (47.7±15.9 pg/ml) concentrations were lower than healthy free‐ranging, short‐term rehabilitated or unhealthy manatees. Capture time was not significantly correlated with cortisol; ACTH correlation was borderline significant. Cortisol and ACTH were positively correlated with lactate. Zoo Biol 30:17–31, 2011. © 2010 Wiley‐Liss, Inc. 相似文献
253.
254.
255.
Audrey Chong Kendal G. Cooper Laszlo Kari Olof R. Nilsson Chad Hillman Brittany A. Fleming Qinlu Wang Vinod Nair Olivia Steele-Mortimer 《Cell host & microbe》2021,29(7):1177-1185.e6
- Download : Download high-res image (334KB)
- Download : Download full-size image
256.
Shawna S. Kim Sarah Michelsons Kendal Creber Michael J. Rieder Douglas W. Hamilton 《Journal of cell communication and signaling》2015,9(4):361-375
Drug-induced gingival enlargement (DIGE) is a fibrotic condition that can be caused by the antihypertensive drug nifedipine and the anti-seizure drug phenytoin, but the molecular etiology of this type of fibrosis is not well understood and the role of confounding factors such as inflammation remains to be fully investigated. The aim of this study was to develop an ex vivo gingival explant system to allow investigation of the effects of nifedipine and phenytoin alone on human gingival tissue. Comparisons were made to the histology of human DIGE tissue retrieved from individuals with DIGE. Increased collagen, fibronectin, and proliferating fibroblasts were evident, but myofibroblasts were not detected in DIGE samples caused by nifedipine and phenytoin. In healthy gingiva cultured in nifedipine or phenytoin-containing media, the number of cells positive for p-SMAD2/3 increased, concomitant with increased CCN2 and periostin immunoreactivity compared to untreated explants. Collagen content assessed through hydroxyproline assays was significantly higher in tissues cultured with either drug compared to control tissues, which was confirmed histologically. Matrix fibronectin levels were also qualitatively greater in tissues treated with either drug. No significant differences in proliferating cells were observed between any of the conditions. Our study demonstrates that nifedipine and phenytoin activate canonical transforming growth factor-beta signaling, CCN2 and periostin expression, as well as increase collagen density, but do not influence cell proliferation or induce myofibroblast differentiation. We conclude that in the absence of confounding variables, nifedipine and phenytoin alter matrix homeostasis in gingival tissue explants ex vivo, and drug administration is a significant factor influencing ECM accumulation in gingival enlargement. 相似文献
257.
W S Kendal 《Mathematical biosciences》1992,108(1):81-88
To test the hypothesis that the ability to metastasize is determined by multiple point mutations during the expansion of a neoplastic clone, a mathematical model for sequential mutations was derived. Development of the metastatic phenotype was attributed to the mutation of a specific group of genes. The average tumor size was estimated for when a cell should manifest a set number of these mutated genes. In a tumor of 10(9) cells subject to 10(-6) mutations/gene per generation, only one of these genes, on average, should have mutated. To explain the multiplicity of changes associated with the metastatic phenotype, genetic variation at rates greater than 10(-3) variations/gene per generation seems necessary. Possible mechanisms for this variation involve gene amplification, chromosomal aneuploidy, and altered gene regulation rather than point mutation. 相似文献
258.