全文获取类型
收费全文 | 859篇 |
免费 | 55篇 |
出版年
2023年 | 11篇 |
2022年 | 5篇 |
2021年 | 28篇 |
2020年 | 11篇 |
2019年 | 28篇 |
2018年 | 27篇 |
2017年 | 17篇 |
2016年 | 30篇 |
2015年 | 36篇 |
2014年 | 50篇 |
2013年 | 52篇 |
2012年 | 75篇 |
2011年 | 78篇 |
2010年 | 53篇 |
2009年 | 55篇 |
2008年 | 72篇 |
2007年 | 62篇 |
2006年 | 53篇 |
2005年 | 43篇 |
2004年 | 31篇 |
2003年 | 34篇 |
2002年 | 27篇 |
2001年 | 5篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 6篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1983年 | 3篇 |
1953年 | 1篇 |
排序方式: 共有914条查询结果,搜索用时 15 毫秒
911.
Sergey V. Abkin Katerina M. Pankratova Elena Yu. Komarova Irina V. Guzhova Boris A. Margulis 《Cell stress & chaperones》2013,18(3):391-396
The recent advances in designing Hsp70-based anti-cancer vaccines and the ability of the chaperone to penetrate inside a living cell prompted us to develop a non-invasive method for the treatment of surface tumors. We designed hydrogel-containing gel-forming substances and human recombinant Hsp70 and applied them on the surface of a 7-day-old B16F10 melanoma tumor. According to the results of histochemistry, Hsp70 diffused through skin layer inside the B16 tumor, and this transport was proved by biochemical data. The application of Hsp70 gel reduced the rate of tumor growth by 64 % and prolonged the life of animals by 46 %. Increased survival was correlated with the enhancement of B16-specific cytotoxicity and up-regulation of gamma–interferon production. Taken together, the data confirm the anti-tumor effect of pure recombinant Hsp70 delivered intratumorally and demonstrate the relevance of a novel non-invasive technology of Hsp70-based therapy. 相似文献
912.
Irina N. Shalova Katerina Cechalova Zuzana Rehakova Petya Dimitrova Elisa Ognibene Antonio Caprioli Elena V. Schmalhausen Vladimir I. Muronetz Luciano Saso 《Biochimica et Biophysica Acta (BBA)/General Subjects》2007
Recently, a relationship between glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the β-amyloid precursor protein (βAPP) in relationship with the pathogenesis of Alzheimer's disease (AD) has been suggested. Therefore, we studied the specific activity of GAPDH in the different animal models of AD: transgenic mice (Tg2576) and rats treated with β-amyloid, or thiorphan, or lipopolysaccharides (LPS) and interferon γ (INFγ). We observed that GAPDH activity was significantly decreased in the brain samples from TG mice. The injection of β-amyloid, or thiorphan, an inhibitor of neprilysin involved in β-amyloid catabolism, in rat brains resulted in a pronounced reduction of the enzyme activity. The infusion of LPS and IFNγ, which can influence the progression of the AD, significantly reduced the enzyme activity. 相似文献
913.
914.