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排序方式: 共有225条查询结果,搜索用时 78 毫秒
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Nikki Phair Jaco Barendse M. Kyle S. Smith Sophie von der Heyden 《Conservation Genetics》2015,16(4):801-809
223.
Eva N. Rubio-Marrero Gabriele Vincelli Cy M. Jeffries Tanvir R. Shaikh Irene S. Pakos Fanomezana M. Ranaivoson Sventja von Daake Borries Demeler Antonella De Jaco Guy Perkins Mark H. Ellisman Jill Trewhella Davide Comoletti 《The Journal of biological chemistry》2016,291(11):5788-5802
Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including autism and language impairment. Using a combination of biophysical techniques, including small angle x-ray scattering, single particle electron microscopy, analytical ultracentrifugation, and bio-layer interferometry, we present novel structural and functional data that relate the architecture of the extracellular domain of CASPR2 to a previously unknown ligand, Contactin1 (CNTN1). Structurally, CASPR2 is highly glycosylated and has an overall compact architecture. Functionally, we show that CASPR2 associates with micromolar affinity with CNTN1 but, under the same conditions, it does not interact with any of the other members of the contactin family. Moreover, by using dissociated hippocampal neurons we show that microbeads loaded with CASPR2, but not with a deletion mutant, co-localize with transfected CNTN1, suggesting that CNTN1 is an endogenous ligand for CASPR2. These data provide novel insights into the structure and function of CASPR2, suggesting a complex role of CASPR2 in the nervous system. 相似文献
224.
Endophytic Bacteria and Their Potential Applications 总被引:1,自引:0,他引:1
Cindy Lodewyckx Jaco Vangronsveld Fiona Porteous Edward R.B. Moore Safieh Taghavi Max Mezgeay 《植物科学评论》2002,21(6):583-606
225.
Jaco M. Greeff Duncan V. K. Newman 《Evolution; international journal of organic evolution》2011,65(1):203-219
Female hymenoptera are renowned for their ability to adjust offspring sex ratio to local mate competition. When two females share a patch, they frequently produce clutches that differ in size, the female with the larger clutch optimally producing a more female‐biased sex ratio and vice versa. Females can base their sex allocation on their own clutch size only (“self‐knowledge”) or on both females’ clutch sizes (“complete knowledge”). Few studies have genotyped offspring so that each mother's contribution can be considered separately while none has found that both sources of information are used simultaneously. We genotyped 2489 wasps from 28 figs and assigned their maternity to one of the two foundress females. We argue that likelihood is a very convenient method to compare alternative models, while fitness calculations help to appreciate the cost of maladaptation. We find that the pollinating fig wasp Platyscapa awekei simultaneously uses its own as well as the other females clutch size in allocating sex. Indeed, the complete knowledge model explains the data 36 times better than the self‐knowledge model. However, large clutches contained fewer males than the optimal predictions leading to a median selection coefficient of 0.01. 相似文献