内皮素对大鼠肠系膜微血管的作用

应用显微电视录象技术可观察到内皮素(ET)对戊巴比妥钠麻醉的 Wistar 大鼠的肠系膜微血管有收缩作用,血液流速减慢,甚至产生微循环障碍,这个作用相当持久,并呈剂量依赖关系。ET 的这个作用远高于去甲肾上腺素。这些结果提示,ET 作为强烈的微血管收缩剂,在微循环紊乱疾病的发病学中可能具有重要意义。     

猫脑干上涎核节前神经元电活动的观察

在麻醉的32只猫记录了电刺激颌下腺神经支引起的上涎核平均场电位和单位放电。逆行电刺激颌下腺神经支引起的上涎核平均场电位分布在同侧脑干背面闩部头端5.5—8mm处,与过去的组织学结果大致符合。用微电极在上涎核记录了68个对刺激颌下腺神经支有反应的单位,其中33个单位作了碰撞试验。有9个单位符合逆向反应标准,它们是真正的颌下腺节前神经元,逆行反应的潜伏期为14.4±2.5ms,其轴突传导速度为2.9±0.1m/s。其他不符合逆向反应标准的单位,对刺激颌下腺神经支仍能发生反应,估计多为中间神经元。在一部分单位观察了电刺激舌神经或味觉刺激舌引起的反应。根据这些观察对上涎核内存在复杂神经元回路的可能性作了讨论。     

蟾蜍红细胞与网织红细胞染色质蛋白的比较研究Ⅲ·HMG蛋白质

从亚洲蟾蜍(Bufo bufo asiaticus)与鸡红细胞核内分离纯化了HMG蛋白(Highmobility group proteins),经聚丙烯酰胺凝胶电泳鉴定,证明两者的电泳图谱不完全相同,在蟾蜍的红细胞内也能观察到与鸡HMG_(17)相对应位置上的蛋白质区带,但在鸡HMG_(14)相对应的位置上,却能观察到两条显著的蛋白质区带(A及B带)。此外,我们已把蟾蜍成熟红细胞与苯肼诱发后的网织红细胞内的HMG蛋白进行比较,证明两者有显著的差异。网织红细胞内HMG_A和HMG_B蛋白在含量上起了变化,却与成熟的红细胞相反。另外还出现了二条新的蛋白区带(C与D带)。初步的结果暗示了,HMG蛋白类似于非组蛋白、染色质蛋白,在量上的变化将会引起功能上的变化。     

Geographical variability of alpha-1-antitrypsin alleles in China: A study on six Chinese populations

Summary Alpha-1-antitrypsin phenotypes of six Chinese Han populations (20°–45°N. latitude) were determined. The frequency of allele M2 increases from North to South China. The north-south change of M2 appears to be mainly at the expense of alleles M1 and M3. Geographical variability of other variants was also observed. In the northern populations, the most common variants are M4 and Etokyo; in the southern populations, Pweishi, a variant which can not be distinguished electrophoretically from Pyasugi. These results form a distribution pattern of alpha-1-antitrypsin alleles in China.     

克山病是一种“心肌线粒体病(Mitochondrial Cardiomyopathy)”

亚急克病人心肌线粒体内膜电子传递链的琥珀酸氧化酶系,琥珀酸脱氢酶和细胞色素氧化酶活性明显低于对照。H~ -ATP酶的活性及其对寡霉素的敏感性都明显下降。ATP能量化后线粒体膜电位的变化也比对照明显降低。膜脂流动性低于对照。亚急克病人心肌线粒体内观察到较多的电子致密无定形物质,经电镜X射线微区等方法分析,认为这些物质不是Ca_3(PO_4)_2,而可能是一种蛋白质凝聚物。此外,心肌线粒体的硒含量远低于对照,而Ca含量明显高于对照。上述结果都反映亚急克病人心肌线粒体明显损伤。根据克山病患者心肌细胞线粒体结构与功能方面呈现的如此广泛与明显的异常,可将克山病称为“心肌线粒体病(Mitochondrial Cardiomyopathy)”。     

Primary structure of PDC-109, a major protein constituent of bovine seminal plasma

The two major protein components of bovine seminal plasma, PDC-109 and BSP I, have been purified by gel filtration, partition chromatography and reverse-phase high performance liquid chromatography from an 86% ethanol precipitate of bovine seminal plasma ejaculate. The complete 109-residue amino acid sequence of PDC-109 has been established by automated Edman degradation of the intact peptide as well as its proteolytic digestion and cyanogen bromide cleavage fragments. The 12,774 dalton structure has two structurally similar domains of 38 and 41 amino acids, each containing two disulfide bonds.     

河南开封地区间日疟原虫在中华按蚊体内的发育观察

十余年来,广东、河南、陕西等省均报告有形态特殊的间日疟原虫存在,并曾被命名为间日疟原虫多核亚种(Plasmodium vivax multincleatum)(江静波等,1965),或称为变异的间日疟原虫(张奎等,1980),以上命名均是以疟原虫红内期的形态特征为依据,其在蚊体内的发育特征如何,则尚缺乏报告。1979年我们曾初步观察了该虫在蚊体内的发育情况(江静波等,1980),于后,1980年又对该种疟原虫在中华按蚊体内的发育情况进行了较系统的观察,现将结果报告如下:     

A Service for Human Chromosome Studies in Saskatchewan

A service has been developed in Saskatchewan to make available the results of studies of human chromosomes, the material being forwarded to the laboratory by local transport facilities. During the first year of this project chromosome studies were requested for five doubtful cases of trisomy-21 (two were found to be normal) and for 20 definite cases of trisomy-21 in young patients (two had translocations but the parents of both these children had normal karyotypes). Eleven confirmed cases of Turner''s syndrome, two of Klinefelter''s syndrome, and one each of the D and E syndromes were also studied. The largest group for which studies were requested comprised 36 patients with mental retardation; only two abnormal karyotypes were encountered in this group.     

钾营养对水稻光合器功能的效应与谷粒产量的影响

水稻广陆矮四号和威优35盆栽试验的结果表明,施钾使叶绿体内基粒增多,Hill反应及光合磷酸化活力增强。分蘖末期在叶绿体反应液中添加KCl也可提高非环式光合磷酸化活力。适量施钾降低量子需要量可能与上述效应有关。钾使叶片超微结构改善:乳突大而多;硅化程度明显增加,故叶片更直立。叶水势及净光合率提高,两者呈直线正相关。灌桨期剑叶净光合率与谷粒产量呈直线正相关。