全文获取类型
收费全文 | 74篇 |
免费 | 4篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 2篇 |
2019年 | 2篇 |
2018年 | 1篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 6篇 |
2014年 | 2篇 |
2012年 | 5篇 |
2011年 | 5篇 |
2010年 | 4篇 |
2009年 | 2篇 |
2008年 | 4篇 |
2007年 | 2篇 |
2006年 | 1篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2002年 | 6篇 |
2001年 | 2篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 3篇 |
1984年 | 1篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1968年 | 2篇 |
排序方式: 共有78条查询结果,搜索用时 218 毫秒
51.
Two series of (+/-)-2-phenyl-1-(quinolizidin-1 alpha-yl)benzimidazoles, 12A-26A, and (+/-)-2-phenyl-1-(quinolizidin-1 beta-yl)benzimidazoles, 12B-26B, were prepared and tested for the inhibition of human platelets aggregation induced by ADP, collagen, and adrenaline. All epimers A, i.e., 12A-26A, were devoid of any activity against the three agonists, while the epimers B, i.e., 12B-26B, exhibited different degrees of activity, though practically confined against the ADP-induced aggregation. The best compounds were 19B, 24B, and 26B, which inhibited for 69-67% at 260 microM and for 40-29% at 65 microM concentration the ADP (2 microM)-induced aggregation. The observed agonist and spatial structure selectivity warrant further investigations of this kind of benzimidazole derivatives. 相似文献
52.
Paolo Piraino Annamaria Ricciardi Maria Teresa Lanorte Iana Malkhazova Eugenio Parente 《Biotechnology letters》2002,24(18):1477-1482
A procedure for the treatment of electrophoretic patterns is presented and discussed using SDS-PAGE patterns of whole-cell proteins of lactic acid bacteria as an example. Complex patterns consisting of two vectors of data [molecular weights (MW), and band intensities] with varying length were transformed in a single vector of fixed length consisting of band intensities accumulated in classes of MW by a logistic weighting function. The procedure performed better than a commercial software (Diversity Database) in clustering the patterns. 相似文献
53.
Iana Ch. Tsoneva Doncho V. Zhelev Dimiter S. Dimitrov 《Cell biochemistry and biophysics》1986,8(2):89-101
Dielectrophoretic velocities of human red blood cells in an axisymmetric field were measured as a function of the applied
voltage and the distance from the axis of symmetry. The voltage of the alternating electric field (frequency 2 MHz), applied
between two concentric cylindrical metal electrodes (outer and inner radii 0.24 and 1 mm, respectively), was varied up to
19 V. Two kinds of mediums were used: (a) 90% of 2.1% glycine solution and 10% of 5.5% glucose solution and (b) 5.4% sorbitol
solution. The results have shown that in both mediums the cell velocities are proportional to the square of the applied voltage
and inversely proportional to the cube of the distance from the axis of symmetry, as predicted by the theory. The coefficient
of proportionality (dielectrophoretic coefficient) is on the order of 10−25 A2s4kg−1. It depends on the donor of red blood cells and might be used for diagnostic purposes. These results will be used in future
investigations of membrane adhesion, stability and fusion. 相似文献
54.
Francisco J. A. de Paula Iana M. de Araújo Adriana L. Carvalho Jorge Elias Jr. Carlos E. G. Salmon Marcello H. Nogueira-Barbosa 《PloS one》2015,10(6)
Bone marrow harbors a significant amount of body adipose tissue (BMAT). While BMAT might be a source of energy for bone modeling and remodeling, its increment can also represent impairment of osteoblast differentiation. The relationship between BMAT, bone mass and insulin sensitivity is only partially understood and seems to depend on the circumstances. The present study was designed to assess the association of BMAT with bone mineral density in the lumbar spine as well as with visceral adipose tissue, intrahepatic lipids, HOMA-IR, and serum levels of insulin and glucose. This cross-sectional clinical investigation included 31 non-diabetic women, but 11 had a pre-diabetes status. Dual X-ray energy absorptiometry was used to measure bone mineral density and magnetic resonance imaging was used to assess fat deposition in BMAT, visceral adipose tissue and liver. Our results suggest that in non-diabetic, there is an inverse relationship between bone mineral density in lumbar spine and BMAT and a trend persists after adjustment for weight, age, BMI and height. While there is a positive association between visceral adipose tissue and intrahepatic lipids with serum insulin levels, there is no association between BMAT and serum levels of insulin. Conversely, a positive relationship was observed between BMAT and serum glucose levels, whereas this association was not observed with other fat deposits. These relationships did not apply after adjustment for body weight, BMI, height and age. The present study shows that in a group of predominantly non-obese women the association between insulin resistance and BMAT is not an early event, as occurs with visceral adipose tissue and intrahepatic lipids. On the other hand, BMAT has a negative relationship with bone mineral density. Taken together, the results support the view that bone has a complex and non-linear relationship with energy metabolism. 相似文献
55.
56.
57.
Fabian Weikl Christina Tischer Alexander J. Probst Joachim Heinrich Iana Markevych Susanne Jochner Karin Pritsch 《PloS one》2016,11(4)
People spend most of their time inside buildings and the indoor microbiome is a major part of our everyday environment. It affects humans’ wellbeing and therefore its composition is important for use in inferring human health impacts. It is still not well understood how environmental conditions affect indoor microbial communities. Existing studies have mostly focussed on the local (e.g., building units) or continental scale and rarely on the regional scale, e.g. a specific metropolitan area. Therefore, we wanted to identify key environmental determinants for the house dust microbiome from an existing collection of spatially (area of Munich, Germany) and temporally (301 days) distributed samples and to determine changes in the community as a function of time. To that end, dust samples that had been collected once from the living room floors of 286 individual households, were profiled for fungal and bacterial community variation and diversity using microbial fingerprinting techniques. The profiles were tested for their association with occupant behaviour, building characteristics, outdoor pollution, vegetation, and urbanization. Our results showed that more environmental and particularly outdoor factors (vegetation, urbanization, airborne particulate matter) affected the community composition of indoor fungi than of bacteria. The passage of time affected fungi and, surprisingly, also strongly affected bacteria. We inferred that fungal communities in indoor dust changed semi-annually, whereas bacterial communities paralleled outdoor plant phenological periods. These differences in temporal dynamics cannot be fully explained and should be further investigated in future studies on indoor microbiomes. 相似文献
58.
Fan J Fahr B Stockett D Chan E Cheeti S Serafimova I Lu Y Pham P Walker DH Hoch U Choong IC 《Bioorganic & medicinal chemistry letters》2008,18(23):6236-6239
Modifications of the isonipecotic acid fragment of SNS-032 results in analogs which are more permeable and lower effluxed than SNS-032. The enantiomerically pure synthesis and the in vivo profile of analog 20 is described. 相似文献
59.
Oleg I. Artyushin Elena V. Sharova Natalya M. Vinogradova Galina K. Genkina Aleksandra A. Moiseeva Zinaida S. Klemenkova Iana R. Orshanskaya Anna A. Shtro Renata A. Kadyrova Vladimir V. Zarubaev Olga I. Yarovaya Nariman F. Salakhutdinov Valery K. Brel 《Bioorganic & medicinal chemistry letters》2017,27(10):2181-2184
A series of seventeen tetrazole derivatives of 1,7,7-trimethyl-[2.2.1]bicycloheptane were synthesized using click chemistry methodology and characterized by spectral data. Studies of cytotoxicity and in vitro antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cells of the compounds obtained were performed. The structure-activity relationship analysis suggests that to possess virus-inhibiting activity, the compounds of this group should bear oxygen atom with a short linker (C2-C4), either as a hydroxyl group (18, 19, 29), keto-group (21) or as a part of a heterocycle (24). These compounds demonstrated low cytotoxicity along with high anti-viral activity. 相似文献
60.
Tatyana M. Khomenko Vladimir V. Zarubaev Iana R. Orshanskaya Renata A. Kadyrova Victoria A. Sannikova Dina V. Korchagina Konstantin P. Volcho Nariman F. Salakhutdinov 《Bioorganic & medicinal chemistry letters》2017,27(13):2920-2925
Compounds simultaneously carrying the monoterpene and coumarin moieties have been tested for cytotoxicity and inhibition of activity against influenza virus A/California/07/09 (H1N1)pdm09. The structure of substituents in the coumarin framework, as well as the structure and the absolute configuration of the monoterpenoid moiety, are shown to significantly influence the anti-influenza activity and cytotoxicity of the compounds under study. The compounds with a bicyclic pinane framework exhibit the highest selectivity indices (the ratios between the cytotoxicity and the active dose). The derivative of (?)-myrtenol 15c, which is characterized by promising activity, low cytotoxicity, and synthetic accessibility, has the greatest potential among this group of compounds. It exhibited the highest activity when added to the infected cell culture at early stages of viral reproduction. 相似文献