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排序方式: 共有492条查询结果,搜索用时 390 毫秒
81.
Michael B. J. Harfoot Tim Newbold Derek P. Tittensor Stephen Emmott Jon Hutton Vassily Lyutsarev Matthew J. Smith J?rn P. W. Scharlemann Drew W. Purves 《PLoS biology》2014,12(4)
Anthropogenic activities are causing widespread degradation of ecosystems worldwide, threatening the ecosystem services upon which all human life depends. Improved understanding of this degradation is urgently needed to improve avoidance and mitigation measures. One tool to assist these efforts is predictive models of ecosystem structure and function that are mechanistic: based on fundamental ecological principles. Here we present the first mechanistic General Ecosystem Model (GEM) of ecosystem structure and function that is both global and applies in all terrestrial and marine environments. Functional forms and parameter values were derived from the theoretical and empirical literature where possible. Simulations of the fate of all organisms with body masses between 10 µg and 150,000 kg (a range of 14 orders of magnitude) across the globe led to emergent properties at individual (e.g., growth rate), community (e.g., biomass turnover rates), ecosystem (e.g., trophic pyramids), and macroecological scales (e.g., global patterns of trophic structure) that are in general agreement with current data and theory. These properties emerged from our encoding of the biology of, and interactions among, individual organisms without any direct constraints on the properties themselves. Our results indicate that ecologists have gathered sufficient information to begin to build realistic, global, and mechanistic models of ecosystems, capable of predicting a diverse range of ecosystem properties and their response to human pressures. 相似文献
82.
Jacek Bajor Karolina L. Tkaczuk Maksymilian Chruszcz Hutton Chapman Olga Kagan Alexei Savchenko Wladek Minor 《Journal of structural and functional genomics》2014,15(2):73-81
We report a 2.0 Å structure of the CAE31940 protein, a proteobacterial NMT1/THI5-like domain-containing protein. We also discuss the primary and tertiary structure similarity with its homologs. The highly conserved FGGXMP motif was identified in CAE31940, which corresponds to the GCCCX motif located in the vicinity of the active center characteristic for THi5-like proteins found in yeast. This suggests that the FGGXMP motif may be a unique hallmark of proteobacterial NMT1/THI5-like proteins. 相似文献
83.
alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release. 总被引:7,自引:0,他引:7
Platelet activation is tightly regulated by products of the endothelium and platelets including nitric oxide (NO). Excess vascular oxidative stress has been associated with impaired NO release, and antioxidant status has been shown to alter endothelium-derived NO bioactivity. Although physiological levels of a-tocopherol are known to inhibit platelet function, the effect of a-tocopherol on platelet NO release is unknown. Loading platelets with physiologic levels of a-tocopherol increased platelet NO production approximately 1.5-fold (Pa-tocopherol, platelet NO release increased 50% (Pa-Tocopherol-loaded platelets also produced 74% less superoxide as compared with control (Pa-tocopherol inhibited PKC-dependent eNOS phosphorylation as determined by immunoprecipitation. Lastly, platelets isolated from NOS3-deficient mice released 80% less superoxide as compared with control animals (P=0.011), and incubation of NOS III-deficient platelets with 500 mM a-tocopherol only caused a modest additional decrease in platelet superoxide release (NS). Thus, a-tocopherol appears to enhance platelet NO release both in vitro and in vivo through antioxidant- and PKC-dependent mechanisms. 相似文献
84.
Kornelia Jumel Fiona J. J. Fogg David A. Hutton J. P. Pearson Adrian Allen S. E. Harding 《European biophysics journal : EBJ》1997,25(5-6):477-480
The distribution of molecular weights for polymeric colonic mucus glycoprotein or ``mucin' isolated and solubilised in the
presence of protease inhibitors from pig colons is shown to be considerably greater than its ``subunit' (thiol reduction
product) and papain digested forms using the technique of size-exclusion chromatography coupled to multi-angle laser light
scattering, and confirmed by sedimentation equilibrium measurements. The conformation of this mucin is probed by examining
the molecular weight – intrinsic viscosity relationship in terms of the Mark-Houwink-Kuhn-Sakurada analysis for its polymeric
(or ``whole'), reduced and papain-digested forms: an exponent ``a' of (1.1±0.1) is obtained indicating a linear random coil conformation consistent with other mucins. Size-exclusion chromatography
coupled to multi-angle laser light scattering is shown to provide a relatively simple complementary technique to sedimentation
equilibrium for the molecular weight distribution analysis of polydisperse materials.
Received: 29 November 1996 / Accepted: 2 December 1996 相似文献
85.
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87.
Radiotelemetry was used from June 1986 through February 1987 to observe the movements of four Nile crocodiles, Crocodylus niloticus Laurenti, introduced into a resident population at Lake Ngezi, Zimbabwe. The use of surgically-implanted transmitters was the first application of this technique on wild Nile crocodiles. A subadult female (194 cm TL, 35 kg) and two males (256 cm, 81 kg; 348 cm, 260 kg) wandered throughout the area. A large female (297 cm, 149 kg) moved > 12 km from her point of release to Ngezi River and nested; she guarded the nest site through 21 January 1987 when she moved the hatchlings to a nearby creche. A juvenile crocodile (120 cm TL, 8 kg) captured in Lake Ngezi was also monitored from June 1986 to February 1987. It traversed some 15 km of the shoreline of Lake Ngezi and moved as much as 10 km overnight. Evidence is presented that the translocated crocodiles, excluding the nesting female, exhibited exploratory behaviour throughout the nine-month observation period, and did not establish home ranges per se. 相似文献
88.
89.
Steven J. Price Sara Beth Freytag Simon J. Bonner Andrea N. Drayer Brenee' L. Muncy Jacob M. Hutton Christopher D. Barton 《Diversity & distributions》2018,24(9):1242-1251
Aim
Population dynamics are often tightly linked to the condition of the landscape. Focusing on a landscape impacted by mountaintop removal coal mining (MTR), we ask the following questions: (1) How does MTR influence vital rates including occupancy, colonization and persistence probabilities, and conditional abundance of stream salamander species and life stages? (2) Do species and life stages respond similar to MTR mining or is there significant variation among species and life stages?Location
Freshwater and terrestrial habitats in Central Appalachia (South‐eastern Kentucky, USA).Methods
We conducted salamander counts for three consecutive years in 23 headwater stream reaches in forested or previously mined landscapes. We used a hierarchical, N‐mixture model with dynamic occupancy to calculate species‐ and life stage‐specific occupancy, colonization and persistence rates, and abundance given occupancy. We examined the coefficients of the hierarchical priors to determine population variation among species and life stages.Results
Over 3 years, reference sites had greater salamander abundances and were occupied at a much higher rate than streams impacted by MTR. At sites impacted by MTR mining, most salamander species and life stages exhibited reduced initial occupancy, colonization rates, persistence rates and conditional abundance relative to reference stream reaches. Furthermore, the rates in MTR sites showed low variance, reinforcing that species and life stages were responding similar to MTR.Main conclusions
Salamander populations in landscapes modified by MTR mining exhibited significantly reduced vital rates compared to reference sites. Yet, similarity in responses across species suggests that management or restoration may benefit the entire salamander assemblage. For example, reforestation could reduce landscape resistance, repair altered hydrologic regimes and allow for higher rates of colonization and persistence in streams impacted by MTR.90.
The sequences of the 5' long-terminal repeat (LTR) and adjacent leader
regions of 27 full-length copia elements isolated from natural populations
of Drosophila melanogaster, D. simulans, and D. mauritiana are presented.
Phylogenetic analyses indicate that although D. melanogaster copia elements
are distinct from those of D. simulans and D. mauritiana, the elements of
these latter two species are not distinguishable from one another. LTRs and
adjacent 5' leader regions of elements isolated from D. simulans and D.
mauritiana are structurally similar to one another and carry substantial
deletional variation mapping to regions previously identified as being of
potential importance for copia expression.
相似文献