全文获取类型
收费全文 | 301篇 |
免费 | 31篇 |
出版年
2021年 | 6篇 |
2019年 | 4篇 |
2017年 | 4篇 |
2016年 | 8篇 |
2015年 | 6篇 |
2014年 | 6篇 |
2013年 | 6篇 |
2012年 | 10篇 |
2011年 | 14篇 |
2010年 | 11篇 |
2009年 | 7篇 |
2008年 | 10篇 |
2007年 | 11篇 |
2006年 | 12篇 |
2005年 | 14篇 |
2004年 | 16篇 |
2003年 | 20篇 |
2002年 | 13篇 |
2001年 | 13篇 |
2000年 | 12篇 |
1999年 | 11篇 |
1998年 | 9篇 |
1997年 | 8篇 |
1996年 | 4篇 |
1995年 | 6篇 |
1993年 | 3篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1983年 | 3篇 |
1981年 | 3篇 |
1978年 | 2篇 |
1966年 | 2篇 |
1940年 | 2篇 |
1938年 | 2篇 |
1937年 | 2篇 |
1935年 | 2篇 |
1930年 | 2篇 |
1928年 | 2篇 |
1927年 | 2篇 |
1917年 | 2篇 |
1916年 | 2篇 |
1910年 | 3篇 |
1909年 | 2篇 |
1907年 | 2篇 |
1901年 | 4篇 |
排序方式: 共有332条查询结果,搜索用时 15 毫秒
71.
72.
B. Borisch Chappuis H. Müller J. Stutte M. M. Hey K. Hübner H. K. Müller-Hermelink 《Virchows Archiv. B, Cell pathology including molecular pathology》1989,58(1):199-205
Fourteen examples of non-Hodgkin’s lymphoma (NHL) and four of Hodgkin’s disease in patients with AIDS as well as lymph nodes
exhibiting changes related to the lymphadenopathy syndrome (LAS) from 11 HIV-positive individuals were studied for the presence
of Epstein-Barr virus (EBV) genome both by in situ DNA hybridization and blotting techniques. Both methods were performed
using formalin-fixed paraffin-embedded material. All the NHLs were of high malignancy and all but one were of the B-cell type.
Of the four examples of Hodgkin’s disease, two were lymphocytic predominant, one of mixed cellularity and one of the nodular
sclerosing variety. The lymph nodes of patients with LAS were mostly stage I with marked follicular hyperplasia. In 7 of the
14 NHLs the presence of EBV-DNA was clearly demonstrated by dot-blotting and by in situ hybridization. All lymph nodes from
the patients with LAS and AIDS-related Hodgkin’s disease were negative for EBV by dot-blot and in situ hybridization assays.
We conclude that EBV plays a role in the development of AIDS-related lymphomas, but the fact that half these lymphomas are
EBV-negative suggests that other mechanisms such as polyclonal stimulation of B-cells by HIV products may also be important.
This study was supported by the DFG, SFB 172 to BBC and HKMH and by the BMFT grant 01KI 88061 to BBC 相似文献
73.
74.
Background
Amino acid repeat-containing proteins have a broad range of functions and their identification is of relevance to many experimental biologists. In human-infective protozoan parasites (such as the Kinetoplastid and Plasmodium species), they are implicated in immune evasion and have been shown to influence virulence and pathogenicity. RepSeq is a new database of amino acid repeat-containing proteins found in lower eukaryotic pathogens. The RepSeq database is accessed via a web-based application which also provides links to related online tools and databases for further analyses. 相似文献75.
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold
Vaccaro WD Sher R Berlin M Shih NY Aslanian R Schwerdt JH McCormick KD Piwinski JJ West RE Anthes JC Williams SM Wu RL She HS Rivelli MA Mutter JC Corboz MR Hey JA Favreau L 《Bioorganic & medicinal chemistry letters》2006,16(2):395-399
We report the discovery of novel histamine H(3) receptor antagonists based on 4-[(1H-imidazol-4-yl)methyl]piperidine. The most potent compounds in the series (e.g., 7) result from the attachment of a substituted aniline amide to the main pharmacophore piperidine via a two-methylene linker. 相似文献
76.
77.
78.
Michelle S Teng Martijn PJ Dekkers Ling Bee Ng Suzanne Rademakers Gert Jansen Andrew G Fraser John McCafferty 《BMC biology》2006,4(1):22-9
Background
G-protein-coupled receptors (GPCRs) play a crucial role in many biological processes and represent a major class of drug targets. However, purification of GPCRs for biochemical study is difficult and current methods of studying receptor-ligand interactions involve in vitro systems. Caenorhabditis elegans is a soil-dwelling, bacteria-feeding nematode that uses GPCRs expressed in chemosensory neurons to detect bacteria and environmental compounds, making this an ideal system for studying in vivo GPCR-ligand interactions. We sought to test this by functionally expressing two medically important mammalian GPCRs, somatostatin receptor 2 (Sstr2) and chemokine receptor 5 (CCR5) in the gustatory neurons of C. elegans. 相似文献79.
PJ Waller B-L Ljungström O Schwan L Rudby Martin DA Morrison A Rydzik 《Acta veterinaria Scandinavica》2006,47(1):23-10
Trials were conducted on 3 commercial sheep farms in Sweden to assess the effect of administering spores of the nematode trapping fungus, Duddingtonia flagrans, together with supplementary feed to lactating ewes for the first 6 weeks from turn-out on pastures in spring. Also control groups of ewes, receiving only feed supplement, were established on all 3 farms. Groups were monitored by intensive parasitological investigation. The ewes and their lambs were moved in late June to saved pastures for summer grazing, the lambs receiving an anthelmintic treatment at this time. After approximately 6 weeks on summer pasture the lambs were weaned, treated a second time with anthelmintic, and returned to their original lambing pastures for finishing. Decisions as to when lambs were to be marketed were entirely at the discretion of the farmer co-operators. No difference in lamb performance was found between the two treatments on all three farms. This was attributed to the high levels of nutrition initially of the ewes limiting their post-partum rise in nematode faecal egg counts in spring, which in turn resulted in low levels of nematode infection on pastures throughout the autumn period. Additionally, pastures were of good quality for the lambs during the finishing period, so they grew at optimal rates as far as the farmers were concerned. 相似文献
80.