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91.
Eliana Cordero Jan Rüger Dominik Marti Abdullah S. Mondol Thomas Hasselager Karin Mogensen Gregers G. Hermann Jürgen Popp Iwan W. Schie 《Journal of biophotonics》2020,13(2)
Existing approaches for early‐stage bladder tumor diagnosis largely depend on invasive and time‐consuming procedures, resulting in hospitalization, bleeding, bladder perforation, infection and other health risks for the patient. The reduction of current risk factors, while maintaining or even improving the diagnostic precision, is an underlying factor in clinical instrumentation research. For example, for clinic surveillance of patients with a history of noninvasive bladder tumors real‐time tumor diagnosis can enable immediate laser‐based removal of tumors using flexible cystoscopes in the outpatient clinic. Therefore, novel diagnostic modalities are required that can provide real‐time in vivo tumor diagnosis. Raman spectroscopy provides biochemical information of tissue samples ex vivo and in vivo and without the need for complicated sample preparation and staining procedures. For the past decade there has been a rise in applications to diagnose and characterize early cancer in different organs, such as in head and neck, colon and stomach, but also different pathologies, for example, inflammation and atherosclerotic plaques. Bladder pathology has also been studied but only with little attention to aspects that can influence the diagnosis, such as tissue heterogeneity, data preprocessing and model development. The present study presents a clinical investigative study on bladder biopsies to characterize the tumor grading ex vivo, using a compact fiber probe‐based imaging Raman system, as a crucial step towards in vivo Raman endoscopy. Furthermore, this study presents an evaluation of the tissue heterogeneity of highly fluorescent bladder tissues, and the multivariate statistical analysis for discrimination between nontumor tissue, and low‐ and high‐grade tumor. 相似文献
92.
Hermann Grote 《Journal of Ornithology》1923,71(2-3):366-369
Ohne Zusammenfassung 相似文献
93.
Hermann Desselberger 《Journal of Ornithology》1930,78(3):328-376
Ohne Zusammenfassung 相似文献
94.
95.
B. Hermann 《Genetica》1973,44(4):579-587
The chromosome complement of Meriones tristrami Thomas (Rodentia, Gerbillinae), the Israel desert jird, studied by the new technique of chromosome identification (Q and G banding) is described. The diploid number is 72. There are two pairs of submetacentric autosomes (1 and 2) and 33 pairs of acrocentric autosomes. The X chromosome is the largest submetacentric and the Y is the fourth in length among the submetacentric chromosomes of the karyotype. The Fundamental Number (F.N.) is therefore 78 and not 76 as described by Matthey in 1957.
(Travail effectué avec l'appui du Fonds de la Recherche Scientifique Médicale). 相似文献
(Travail effectué avec l'appui du Fonds de la Recherche Scientifique Médicale). 相似文献
96.
97.
In order to study the receptor system for adrenocortical steroids in rat brain the synthetic glucocorticoid RU 28362 (11 beta, 17 beta-dihydroxy-6-methyl-17 alpha-(1-propynyl) androsta-1,4,6-trien-3-one) has been used for photoaffinity labeling. Competition and dissociation studies revealed a single class of binding sites for RU 28362 in rat brain cytosol. Photoaffinity labeling was performed by u.v.-irradiation for 2 min with a coupling efficiency of about 25%. The high efficiency permitted investigation of crude cytosolic preparations under denaturating conditions. Sodium dodecyl sulfate (SDS) and high resolution two-dimensional gel electrophoresis confirmed the high specificity of the photoaffinity labeling. The molecular weight (93 kD) as well as the isoelectric point (5.6) evaluated by these methods corresponded well to data reported for the classical glucocorticoid receptor in rat liver. 相似文献
98.
Edward B. Blanchard Maria L. Peters Christiane Hermann Shannon M. Turner Todd C. Buckley Kristine Barton Mark P. Dentinger 《Applied psychophysiology and biofeedback》1997,22(4):227-245
In order to test for the specific therapeutic effects of thermal biofeedback (TBF) for hand warming on vascular headache (HA),
70 patients with chronic vascular HA were randomly assigned to TBF for hand warming, TBF for hand cooling, TBF for stabilization
of hand temperature, or biofeedback to suppress alpha in the EEG. Patients in each condition initially had high levels of
expectation of therapeutic benefit and found the treatment rationales highly credible. Participants in each condition received
12 treatment sessions on a twice-per-week basis. Based on daily HA diary data gathered for 4 weeks prior to treatment and
4 weeks after treatment, HA Index was significantly (p=.003) reduced as was HA medication consumption. There were no differential
reducations in HA Index or Medication Index among the four conditions. Global self-reports of improvement gathered at the
end of the post-treatment monitoring period also did not differ among the four conditions. We were unable to demonstrate a
specific effect of TBF for hand warming on vascular HA activity. 相似文献
99.
Hermann von Guttenberg 《Planta》1930,11(4):676-682
Ohne ZusammenfassungMit 6 Textabbildungen. 相似文献
100.
Hermann Kuckuck 《Molecular & general genetics : MGG》1938,75(1):24-54
Ohne ZusammenfassungMit 34 Tabellen und 2 Textfiguren 相似文献