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排序方式: 共有219条查询结果,搜索用时 15 毫秒
211.
Gongi Wejdene Cordeiro Nereida Pinchetti Juan Luis Gomez Ouada Hatem Ben 《Journal of applied phycology》2022,34(3):1423-1434
Journal of Applied Phycology - Extracellular polymeric substances (EPSs) produced by the filamentous cyanobacterium identified as Leptolyngbya sp. IkmLPT16 were isolated and characterized... 相似文献
212.
Zainab M. Elsayed Wagdy M. Eldehna Marwa M. Abdel-Aziz Mahmoud A. El Hassab Eslam B. Elkaeed Tarfah Al-Warhi Hatem A. Abdel-Aziz Sahar M. Abou-Seri Eman R. Mohammed 《Journal of enzyme inhibition and medicinal chemistry》2021,36(1):384
Joining the global fight against Tuberculosis, the world''s most deadly infectious disease, herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids (5a–m and 9a–c) as promising anti-tubercular and antibacterial agents. The anti-tubercular activity of the target hybrids was evaluated against drug-susceptible M. tuberculosis strain (ATCC 27294) where hybrids 5d, 5g and 5h were found to be as potent as INH with MIC = 0.24 µg/mL, also the activity was evaluated against Isoniazid/Streptomycin resistant M. tuberculosis (ATCC 35823) where compounds 5g and 5h showed excellent activity (MIC = 3.9 µg/mL). Moreover, the target hybrids were examined against six bronchitis causing-bacteria. Most derivatives exhibited excellent antibacterial activity. K. pneumonia emerged as the most sensitive strain with MIC range: 0.49–7.81 µg/mL. Furthermore, a molecular docking study has proposed DprE1 as a probable enzymatic target for herein reported isatin-nicotinohydrazide hybrids, and explored the binding interactions within the vicinity of DprE1 active site. 相似文献
213.
Termites are eusocial arthropod decomposers,and improve soil fertility,crop yield,and also are used by humans for their ben efits across the world.However,some species of termites are becoming a threat to the farming community as they are directly and indirectly causing major losses to the agricultural system.It is estimated that termites cost the global economy more than 40 billion USD annually,and considerable research has been done on their management.In this review,we present the available information related to sustainable and integrated termite management practices(ITM).Furthermore,we insist that the better management of this menace can be possible through:(i)improving traditional methods to keep termites away from crops;(ii)improving agricultural practices to maintain plants with more vigor and less susceptible to termite attack;and(iii)integration of available techniques to reduce termite infestation in crops and surroundings.The application of an effective combination of traditional practices with recently developed approaches is the best option for agricultural growers.Moreover,keeping in mind the beneficial nature of this pest,more innovative efforts for its management,particularly using rapidly emerging technology(e.g.,RNA interference),are needed. 相似文献
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Layeb Hatem Nacereddine Abdelmalek Khorief Djerourou Abdelhafid Domingo Luis R. 《Journal of molecular modeling》2014,20(7):1-11
Journal of Molecular Modeling - Hyperjovinol-A ((2-methyl-1-(2,4,6-trihydroxy-3-(3-hydroxy-3,7-dimethyloct-6-enyl)phen yl)propan-1-one) is an acylated phloroglucinol isolated from Hypericum Jovis... 相似文献
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Hatem Zgallai Kathy Steppe Raoul Lemeur 《植物学报(英文版)》2006,48(6):679-685
A greenhouse experlment was performed In order to Investigate the effects of dlfferent levels of water stress on leaf water potentlal (ψw), stomatal resistance (rs), protein content and chlorophyll (Chl) content of tomato plants (Lycoperslcon esculentum Mill. cv. Nlkita). Water stress was Induced by addlng polyethylene glycol (PEG 6 000) to the nutrlent solution to reduce the osmotlc potential (ψs). We Investlgated the behavlor of antl-oxldant enzymes, such as catalase (CAT) and superoxide dlsmutase (SOD), durlng the development of water stress. Moderate and severe water stress (i.e. ψs= -0.51 and -1.22 MPa, respectlvely) caused a decrease In ψw for all treated (water-stressed) plants compared with control plants, wlth the reductlon belng more pronounced for severely stressed plants. In addltion, rs was slgnlflcantly affected by the Induced water stress and a decrease in leaf soluble protelns and Chl content was observed. Whereas CAT actlvlty remained constant, SOD actlvlty was increased in water-stressed plants compared wlth unstressed plants. These results Indicate the possible role of SOD as an anti-oxidant protector system for plants under water stress condltlons. Moreover, It suggests the possibllity of using this enzyme as an addltional screening crlterlon for detecting water stress in plants. 相似文献
219.
Wagdy M. Eldehna Mahmoud F. Abo-Ashour Tarfah Al-Warhi Sara T. Al-Rashood Amal Alharbi Rezk R. Ayyad Khayal Al-Khayal Maha Abdulla Hatem A. Abdel-Aziz Rehan Ahmad Radwan El-Haggar 《Journal of enzyme inhibition and medicinal chemistry》2021,36(1):319
Mitochondrial anti-apoptotic Bcl2 and BclxL proteins, are overexpressed in multiple tumour types, and has been involved in the progression and survival of malignant cells. Therefore, inhibition of such proteins has become a validated and attractive target for anticancer drug discovery. In this manner, the present studies developed a series of novel isatin–indole conjugates (7a-j and 9a-e) as potential anticancer Bcl2 and BclxL inhibitors. The progression of the two examined colorectal cancer cell lines was significantly inhibited by all of the prepared compounds with IC50 ranges132–611 nM compared to IC50 = 4.6 µM for 5FU, against HT-29 and IC50 ranges 37–468 nM compared to IC50 = 1.5 µM for 5FU, against SW-620. Thereafter, compounds 7c and 7g were selected for further investigations. Interestingly, both compounds exhibited selective cytotoxicity against both cell lines with high safety to normal fibroblast (HFF-1). In addition, both compounds 7c and 7g induced apoptosis and inhibited Bcl2 and BclxL expression in a dose-dependent manner. Collectively, the high potency and selective cytotoxicity suggested that conjugates 7c and 7g could be a starting point for further optimisation to develop novel pro-apoptotic and antitumor agents towards colon cancer. 相似文献