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111.
Sexual Hyperactivity and Reduced Longevity of dunce Females of Drosophila melanogaster 总被引:1,自引:1,他引:0 下载免费PDF全文
The dunce gene of Drosophila melanogaster codes for a cyclic adenosine-3',5'-monophosphate-specific phosphodiesterase. Mutations of dunce alter or abolish the activity of this enzyme, produce elevated cAMP levels, cause recessive female sterility, and produce learning deficiencies in both sexes. Aberrant male sexual behavior has also been associated with the memory defects of dunce mutants. Here we show that the longevity of dunce mutant females, homozygous for null-enzyme alleles, is reduced by 50% in the presence of males compared to control dunce females kept without males. Mutant dunce females, mate every 22-24 hr. We propose a cause-effect relationship between mating and reduced longevity. Pheromones or peptides transferred during mating may activate adenylate cyclase and create an increase in cAMP levels that cannot be damped in dunce females. This increase may affect basic physiological functions and lead to reduced longevity. 相似文献
112.
Fifteen classical linkage groups were identified in two salmonid species (Salmo trutta and Salmo gairdneri) and three fertile, interspecific hybrids (S. gairdneri X Salmo clarki, Salvelinus fontinalis X Salvelinus namaycush and S. fontinalis X Salvelinus alpinus) by backcrossing multiply heterozygous individuals. These linkage relationships of electrophoretically detected, protein coding loci were highly conserved among species. The loci encoding the enzymes appeared to be randomly distributed among the salmonid chromosomes. Recombination frequencies were generally greater in females than in males. In males, certain linkage groups were pseudolinked with other linkage groups, presumably because of facultative multivalent pairing and directed disjunction of chromosomes. Five such pseudolinkage groups were identified and they also appeared to be common among species and hybrids. Duplicate loci were never classically linked with each other, although some exhibited pseudolinkage and some showed evidence of exchanging alleles. Gene-centromere recombination frequencies estimated from genotypic distributions of gynogenetic offspring were consistent with map locations inferred from female intergenic recombination frequencies. These linkage relationships support the contention that all extant salmonids arose from a common tetraploid progenitor and that this progenitor may have been a segmental allotetraploid. 相似文献
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Judit Kapocsi George T. Somogyi Nandor Ludvig Peter Serfozo Laszlo G. Harsing Jr. Russell J. Woods E. Sylvester Vizi 《Neurochemical research》1987,12(2):141-147
Neurochemical and pharmacological evidence has been obtained that noradrenergic varicosities (in mouse and rat vas deferens) and cholinergic varicosities (in the Auerbach's plexus) contain heterogenous alpha2-adrenoceptors through which the release of [3H]noradrenaline and [3H]acetylcholine can be modulated. The quantitative data also support the hypothesis that different noradrenaline and xylazine sensitive alpha2-adrenoceptors are present prejunctionally in the vas deferens and Auerbach's plexus preparations. Prazosin, although it has a presynaptic inhibitory effect on alpha2-adrenoceptors of noradrenergic axon terminals, has no effect on cholinergic axon terminals. These data suggest that there are two different types of alpha2-adrenoceptors at the presynaptic axon terminals.Special Issue Dedicated to Dr. Abel Lajtha 相似文献
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118.
Herbert N. Arst Jr. David Tollervey Mark X. Caddick 《Molecular & general genetics : MGG》1989,215(2):364-367
Summary The areA
r
-18 mutation is a loss-of-function mutation in areA, the positive acting regulatory gene mediating nitrogen metabolite repression in Aspergillus nidulans. It results from a reciprocal translocation which splits the coding region into 5 and 3 moieties. Surprisingly, we have selected rare intracistronic revertants of areA
r
-18. From crosses heterozygous for areA
r
-18 revertant alleles, duplication-deficiency progeny containing two copies of a substantial portion of chromosome IV but lacking part of chromosome III, including the 5 moiety of areA, have been obtained. For all four revertants analysed genetically, growth properties of these duplication-deficiency strains indicate that the reversion events involve the 3 portion of areA and that the 5 portion of areA is unnecessary for the revertant phenotype. This conclusion was directly confirmed for one revertant using Southern blotting. As all four reversion events involve additional chromosomal rearrangements, they probably fuse functional promoters, ribosome binding sites and in frame initiation codons to the 3 portion of the gene. In the course of characterisation of these mutations, new mapping data for a large region of chromosome IV have been generated, and a new reciprocal translocation activating the cryptic regulatory gene areB, whose product can substitute for that of areA, has been identified. 相似文献
119.
Atsuko Matsuoka Akiko Hirosawa Shinasku Natori Shigeo Iwasaki Toshio Sofuni Motoi Ishidate Jr. 《Mutation research》1989,215(2):179-185
The chromosomal aberration test using a Chinese hamster lung cell line (CHL) was carried out on ptaquiloside and its related compounds, hypoloside B, hypoloside C, illudin M and illudin S. Ptaquiloside induced chromosomal aberrations at doses as low as 4.5 μg/ml (0.0113 mM). The clastogenic effect was ph-dependent. The same activity was observed at a 90-fold higher dose at pH 5.3 in the culture medium compared with the activity at pH 74. or pH 8.0. Both hypoloside B and hypoloside C were also clastogenic at almost the same dose levels as that of ptaquiloside. Illudin M and illudin S were also potet clastogens and induced aberrations at much lower doses than ptaquiloside. These results suggest that the clastogenic effect is involved in the mechanism of carcinogenic potency of ptaquiloside in animals. 相似文献
120.
T. Payson Wilber Jr. 《Oecologia》1989,81(1):6-15
Summary Two populations (salt marsh and seagrass bed) of the hermit crab Pagurus longicarpus were sampled to examine associations between shell characteristics and egg production. Multivariate statistical analyses controlled for crab size and time of year, variables that otherwise could be confounded with shell effects. Although correlations between shell characteristics and reproduction existed in both populations, generalizations could not be made because associations varied within and between populations. Shell species was not associated with a female's reproductive state (i.e., whether or not she was barren when sampled) in either population. In the seagrass population, medium-large and large females occupying severely damaged or fouled shells were half as likely to be reproductive as females occupying other shell conditions. However, there was no association between shell condition and reproductive state for small and small-medium females in the seagrass population or among all females in the salt marsh population. In the seagrass population, small through medium-large reproductive females occupied shells more similar to their predicted shell size, regardless of whether the occupied shell was relatively small or large, than nonreproductive females. In contrast, relative shell sizes of reproductive and nonreproductive females were similar for large females in the seagrass population and all females in the salt marsh population. Clutch sizes were enhanced for females occupying Polinices duplicatus shells or shells larger than their predicted shell size in the seagrass population. Relative shell size also was associated with clutch size in the salt marsh population, but crabs occupying shells similar to their predicted shell size had the largest clutches. 相似文献