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Background
Calcineurin (CaN) is an important serine-threonine phosphatase (PP2B), which plays a crucial role in calcium-calmodulin mediated signal transduction events. Calcineurin has been implicated in pathogenesis of various diseases cardiac hypertrophy, diabetic neuropathy and Alzheimer's, however its role in neoplasia remains unclear. 相似文献15.
A genomic library of partially EcoRI-digested DNA from the lesser snow
goose, Anser caerulescens caerulescens, was constructed in the phage vector
Charon 4. Phage containing only unique sequences were identified by
screening plaques with 32P-labeled genomic DNA. Restriction-fragment-
length polymorphisms (RFLPs) were identified by probing DNA from 11-13 male
birds from the breeding colony at La Perouse Bay. Of the 17 probes
examined, all detected RFLPs with at least one of EcoRi, HindIII, Msp1, and
Taq1. Several of them identified highly variable regions with multiple
alleles. These RFLPs are valuable DNA markers that can be used for (1) the
examination of DNA variation, relatedness, and genetic distance and (2)
assessing paternity and maternity. These data suggest that there are higher
levels of variation of DNA sequence in birds than had previously been
thought to exist.
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Portier BP Gruver AM Huba MA Minca EC Cheah AL Wang Z Tubbs RR 《New biotechnology》2012,29(6):665-681
Diagnostics in the field of breast carcinoma are constantly evolving. The recent wave of molecular methodologies, both microscope and non-microscope based, have opened new ways to gain insight into this disease process and have moved clinical diagnostics closer to a 'personalized medicine' approach. In this review we highlight some of the advancements that laboratory medicine technology is making toward guiding the diagnosis, prognosis, and therapy selection for patients affected by breast carcinoma. The content of the article is largely structured by methodology, with a distinct emphasis on both microscope based and non-microscope based diagnostic formats. Where possible, we have attempted to emphasize the potential benefits as well as limitations to each of these technologies. Successful molecular diagnostics, applied in concert within the morphologic context of a patient's tumor, are what will lay the foundation for personalized therapy and allow a more sophisticated approach to clinical trial stratification. The future of breast cancer diagnostics looks challenging, but it is also a field of great opportunity. Never before have there been such a plethora of new tools available for disease investigation or candidate therapy selection. 相似文献
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This study presents data on over 350,000 insured Swedish dogs up to 10 years of age contributing to over one million dog-years
at risk (DYAR) during 1995–2000. A total of 43,172 dogs died or were euthanised and of these 72% had a claim with a diagnosis
for the cause of death. The overall total mortality was 393 deaths per 10,000 DYAR. Mortality rates are calculated for the
10 most common breeds, 10 breeds with high mortality and a group including all other breeds, crudely and for general causes
of death. Proportional mortality is presented for several classifications. Five general causes accounted for 62% of the deaths
with a diagnosis (i.e. tumour (18%), trauma (17%), locomotor (13%), heart (8%) and neurological (6%)). Mortality rates for
the five most common diagnoses within the general causes of death are presented. These detailed statistics on mortality can
be used in breed-specific strategies as well as for general health promotion programs. Further details on survival and relative
risk by breed and age are presented in the companion paper [14]. 相似文献
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