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141.
142.
A significant amount of the primary production in the Southern Ocean and other ice-covered oceans takes place in localized ice edge plankton blooms. The dynamics of these blooms appear to be closely related to seasonal melting of sea ice. Algal cells released from the ice are a possible source of ice edge planktonic assemblages, but evidence for this “seeding” has been equivocal. We compared algal assemblages in ice and water in the Weddell Sea during the austral spring of 1983 at a receding ice edge with a well-developed ice edge bloom. The high degree of similarity between ice and water column assemblages, the spatial and temporal patterns in the distribution and abundances of species, and preliminary evidence for the viability and growth of ice-associated species provide evidence for seeding from sea ice of some species in Antarctica. 相似文献
143.
Maria Luisa Barcena Greta Tonini Natalie Haritonow Pavelas Breiter Hendrik Milting Istvan Baczko Ursula Müller-Werdan Yury Ladilov Vera Regitz-Zagrosek 《Aging cell》2023,22(8):e13894
Linked to exacerbated inflammation, myocarditis is a cardiovascular disease, which may lead to dilated cardiomyopathy. Although sex and age differences in the development of chronic myocarditis have been postulated, underlying cellular mechanisms remain poorly understood. In the current study, we aimed to investigate sex and age differences in mitochondrial homeostasis, inflammation, and cellular senescence. Cardiac tissue samples from younger and older patients with inflammatory dilated cardiomyopathy (DCMI) were used. The expression of Sirt1, phosphorylated AMPK, PGC-1α, Sirt3, acetylated SOD2, catalase, and several mitochondrial genes was analyzed to assess mitochondrial homeostasis. The expression of NF-κB, TLR4, and interleukins was used to examine the inflammatory state in the heart. Finally, several senescence markers and telomere length were investigated. Cardiac AMPK expression and phosphorylation were significantly elevated in male DCMI patients, whereas Sirt1 expression remained unchanged in all groups investigated. AMPK upregulation was accompanied by a preserved expression of all mitochondrial proteins/genes investigated in older male DCMI patients, whereas the expression of TOM40, TIM23, and the mitochondrial oxidative phosphorylation genes was significantly reduced in older female patients. Mitochondrial homeostasis in older male patients was further supported by the reduced acetylation of mitochondrial proteins as indicated by acetylated SOD2. The inflammatory markers NF-κB and TLR4 were downregulated in older male DCMI patients, whereas the expression of IL-18 was increased in older female patients. This was accompanied by progressed senescence in older DCMI hearts. In conclusion, older women experience more dramatic immunometabolic disorders on the cellular level than older men. 相似文献
144.
Greta Monacelli Lili Zhang Winfried Schlee Berthold Langguth Tomás E. Ward Thomas B. Murphy 《Biometrical journal. Biometrische Zeitschrift》2023,65(7):2200203
Recently, the use of mobile technologies in ecological momentary assessments (EMAs) and interventions has made it easier to collect data suitable for intraindividual variability studies in the medical field. Nevertheless, especially when self-reports are used during the data collection process, there are difficulties in balancing data quality and the burden placed on the subject. In this paper, we address this problem for a specific EMA setting that aims to submit a demanding task to subjects at high/low values of a self-reported variable. We adopt a dynamic approach inspired by control chart methods and design optimization techniques to obtain an EMA triggering mechanism for data collection that considers both the individual variability of the self-reported variable and of the adherence. We test the algorithm in both a simulation setting and with real, large-scale data from a tinnitus longitudinal study. A Wilcoxon signed rank test shows that the algorithm tends to have both a higher F1 score and utility than a random schedule and a rule-based algorithm with static thresholds, which are the current state-of-the-art approaches. In conclusion, the algorithm is proven effective in balancing data quality and the burden placed on the participants, especially in studies where data collection is impacted by adherence. 相似文献
145.
Greta Pifat 《Biophysical chemistry》1973,1(2):112-116
Proton magnetic longitudinal T1 relaxation times have been measured for acid (horse) ferrimyoglobin solutions [0.1 M NaCl and KH2PO4, 2 M NaCl and 1 M MgCl2] from 5°C to 35°C in dependence on myoglobin concentration up to 6 mM. The enhancement of the relaxation rate due to the paramagnetic haem iron. which is observed in this temperature range is compared with analogous data for the ferrihaemoglobin solution. The conclusion is that the protons exchanging from the haem pocket with bulk solvent are not those from the water molecule at the sixth ligand site of haem iron. The exchanging protons are more than 4 Å away from the haem iron being closer to it in ferrimyoglobin than in ferrihaemogiobin. This distance becomes larger in solutions with higher salt concentration, the largest difference between 0.1 M NaCl and 1 M MgCl2 being over one Angstrom unit. This indicates a conformational change of the haem pocket, possibly its tightening. 相似文献
146.
147.
Greta A. Fryxell 《Journal of phycology》1978,14(1):62-71
Bacteriastrum furcatum Shadbolt, Chaetoceros bacteriastroides Karsten and C. pseudocurvisetum Mangin are each connected in chains by fusion of silica between setae. The first two have specialized heterovalvate end cells indicating physiological control of the length of chains, but chains of C. pseudocurvisetum have usually been seen broken. There are specialized deeply lobed connecting bands in B. furcatum and C. pseudocurvisetum, allowing the setae of sibling valves to protrude outside the diameter of the chain during their formation. C. bacteriastroides and C. pseudocurvisetum are not identical; differences include presence of small setae, fusion of large setae some distance from the valves, symmetry of apertures between cells, and straight chains of C. bacteriastroides, compared with valve mantle connections with no small setae, large setae joined by crossing over, asymmetry of windows between cells, and curved chains of C. pseudocurvisetum. The evolutionary direction is hypothesized to be from Bacteriastrum to Chaetoceros through C. bacteriastroides. 相似文献
148.
149.
Elizabeth C. Bourne Greta Bocedi Justin M. J. Travis Robin J. Pakeman Rob W. Brooker Katja Schiffers 《Proceedings. Biological sciences / The Royal Society》2014,281(1778)
The evolutionary potential of populations is mainly determined by population size and available genetic variance. However, the adaptability of spatially structured populations may also be affected by dispersal: positively by spreading beneficial mutations across sub-populations, but negatively by moving locally adapted alleles between demes. We develop an individual-based, two-patch, allelic model to investigate the balance between these opposing effects on a population''s evolutionary response to rapid climate change. Individual fitness is controlled by two polygenic traits coding for local adaptation either to the environment or to climate. Under conditions of selection that favour the evolution of a generalist phenotype (i.e. weak divergent selection between patches) dispersal has an overall positive effect on the persistence of the population. However, when selection favours locally adapted specialists, the beneficial effects of dispersal outweigh the associated increase in maladaptation for a narrow range of parameter space only (intermediate selection strength and low linkage among loci), where the spread of beneficial climate alleles is not strongly hampered by selection against non-specialists. Given that local selection across heterogeneous and fragmented landscapes is common, the complex effect of dispersal that we describe will play an important role in determining the evolutionary dynamics of many species under rapidly changing climate. 相似文献
150.
Heterozygous FGF8 mutations in patients presenting cryptorchidism and multiple VATER/VACTERL features without limb anomalies 下载免费PDF全文
Markus Draaken Sadaf S. Mughal Greta Große Alina C. Hilger Gabriel C. Dworschak Thomas M. Boemers Ekkehart Jenetzky Nadine Zwink Martin Lacher Dominik Schmidt Eberhard Schmiedeke Sabine Grasshoff‐Derr Stefanie Märzheuser Stefan Holland‐Cunz Mattias Schäfer Enrika Bartels Kathleen Keppler Markus Palta Johannes Leonhardt Christina Kujath Anke Rißmann Markus M. Nöthen Heiko Reutter Michael Ludwig 《Birth defects research. Part A, Clinical and molecular teratology》2014,100(10):750-759