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61.
62.
Gregorio Moreno-Rueda 《Journal of Ethology》2007,25(3):215-222
Offspring should demand more food than the optimal amount for the parents to bring (parent–offspring conflict), and models
on the evolution of parent–offspring communication suggest that an equilibrium is reached when the costs associated with begging
make it unprofitable for the offspring to increase its level of begging. Empirical evidence for this cost, however, is mixed,
and the conclusions of most of authors are that begging is inexpensive. In this study, the existing empirical evidence for
this cost is reviewed. One cost proposed is the attraction of predators due to begging calls, but empirical support for this
cost is low. However, studies performed cannot dismiss such a cost. Another possible cost is the metabolic expenditure, but
empirical evidence for this cost is mixed, with some works contending that it is low, while others deem it important. Other
possible metabolic costs have not been studied. A loss of inclusive fitness may be an important cost for the evolution of
begging, and robust empirical evidence does exist for this cost. Costs associated with brood reduction also are reviewed.
In conclusion, there is not enough empirical evidence to test the models on the evolution of begging. Most costs proposed
have not yet been studied or the approach used has been insufficient to reject the null hypothesis (i.e., absence of cost). 相似文献
63.
Jesudason EP Baben B Ashok BS Masilamoni JG Kirubagaran R Jebaraj WC Jayakumar R 《Molecular and cellular biochemistry》2007,298(1-2):69-81
Aβ vaccination as a therapeutic intervention of Alzheimer’s has many challenges, key among them is the regulation of inflammatory
processes concomitant with excessive generation of free radicals seen during such interventions. Here we report the beneficial
effects of melatonin on inflammation associated with Aβ vaccination in the central and peripheral nervous system of mice.
Mice were divided into three groups (n = 8 in each): control, inflammation (IA), and melatonin-treated (IAM). The brain, liver, and spleen samples were collected
after 5 days for quantitative assessment of plasma lipid peroxides (LPO), an oxidative stress marker, and antioxidant enzymes
such as superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (Gpx). IA group mice have
shown the elevated concentration of LPO significantly while there was a reduction at antioxidant enzyme levels. In addition,
a significant (P < 0.05) reduction in neurotransmitters like dopamine (DA), 5-hydroxytryptamine (5-HT), and norepinephrine (NE) was also observed
in the IA group mice. Nevertheless, their metabolites, such as homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA)
increased significantly (P < 0.05) as compared to control. Samples were further evaluated at microscopic level to examine the neuropathological changes
by immunohistochemical methods. Melatonin treatment effectively reversed these above changes and normalized the LPO and antioxidant
enzyme levels (P < 0.05). Furthermore, melatonin salvaged the brain cells from inflammation. Our Immunohistochemical findings in the samples
of melatonin-treated animals (IAM group) indicated diminished expression of glial fibrillary acidic protein (GFAP) and nuclear
factor kappa B (NfκB) than those observed in the IA group samples. Our results suggest that administration of melatonin protects
inflammation associated with Aβ vaccination, through its direct and indirect actions and it can be an effective adjuvant in
the development of vaccination in immunotherapy for Alzheimer’s disease (AD). 相似文献
64.
PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion 总被引:1,自引:0,他引:1
Scarchilli L Camaioni A Bottazzi B Negri V Doni A Deban L Bastone A Salvatori G Mantovani A Siracusa G Salustri A 《The Journal of biological chemistry》2007,282(41):30161-30170
Pentraxin 3 (PTX3) and heavy chains (HCs) of inter-alpha-trypsin inhibitor (IalphaI) are essential for hyaluronan (HA) organization within the extracellular matrix of the cumulus oophorus, which is critical for in vivo oocyte fertilization and female fertility. In this study, we examined the possibility that these molecules interact and cooperate in this function. We show that HCs and PTX3 colocalize in the cumulus matrix and coimmunoprecipitate from cumulus matrix extracts. Coimmunoprecipitation experiments and solid-phase binding assays performed with purified human IalphaI and recombinant PTX3 demonstrate that their interaction is direct and not mediated by other matrix components. PTX3 does not bind to IalphaI subcomponent bikunin and, accordingly, bikunin does not compete for the binding of PTX3 to IalphaI, indicating that PTX3 interacts with IalphaI subcomponent HC only. Recombinant PTX3-specific N-terminal region, but not the PTX3-pentraxin C-terminal domain, showed the same ability as full-length protein to bind to HCs and to enable HA organization and matrix formation by Ptx3(-/-) cumulus cell oocyte complexes cultured in vitro. Furthermore, a monoclonal antibody raised against PTX3 N terminus, which inhibits PTX3/IalphaI interaction, also prevents recombinant full-length PTX3 from restoring a normal phenotype to in vitro-cultured Ptx3(-/-) cumuli. These results indicate that PTX3 directly interacts with HCs of IalphaI and that such interaction is essential for organizing HA in the viscoelastic matrix of cumulus oophorus, highlighting a direct functional link between the two molecules. 相似文献
65.
Gregorio C Eduardo S Rodrigues LC Regueira MA Fraga R Riveiros R Maestro M Mouriño A 《The Journal of steroid biochemistry and molecular biology》2007,103(3-5):227-230
Hapten derivatives of 25-hydroxyvitamin D(3) and 1alpha,25-dihydroxyvitamin D(3) were synthesized using the Wittig-Horner approach. Both haptens bearing a carboxylic group at the side chain that can be linked to a protein for raising antibodies of potential utility for the determination of 25-hydroxyvitamin D(3), 1alpha,25-dihydroxyvitamin D(3) and 1alpha-hydroxylated vitamin D(3) analogues. 相似文献
66.
Marie-Pierre Ledru Maria Luisa Ferraz Salatino Gregorio Ceccantini Antonio Salatino Fabio Pinheiro Jean-Christophe Pintaud 《Diversity & distributions》2007,13(6):761-771
For decades, palynologists working in tropical South America are using the genus Podocarpus as a climate indicator although without referring to any modern data concerning its distribution and limiting factors. With the aim to characterize the modern and past distribution of the southern conifer Podocarpus in Brazil and to obtain new information on the distribution of the Atlantic rainforest during the Quaternary, we examined herbarium data to locate the populations of three Brazilian endemic Podocarpus species: P. sellowii, P. lambertii , and P. brasiliensis , and extracted DNA from fresh leaves from 26 populations. Our conclusions are drawn in the light of the combination of these three disciplines: botany, palynology, and genetics. We find that the modern distribution of endemic Podocarpus populations shows that they are widely dispersed in eastern Brazil, from north to south and reveals that the expansion of Podocarpus recorded in single Amazonian pollen records may have come from either western or eastern populations. Genetic analysis enabled us to delimit regional expansion: between 5° and 15° S grouping northern and central populations of P. sellowii expanded c . 16,000 years ago; between 15° and 23° S populations of either P. lambertii or sellowii expanded at different times since at least the last glaciation; and between 23° and 30° S, P. lambertii appeared during the recent expansion of the Araucaria forest. The combination of botany, pollen, and molecular analysis proved to be a rapid tool for inferring distribution borders for sparse populations and their regional evolution within tropical ecosystems. Today the refugia of rainforest communities we identified are crucial hotspots to allow the Atlantic forest to survive under unfavourable climatic conditions and, as such, offer the only possible opportunity for this type of forest to expand in the event of a future climate change. 相似文献
67.
Randrianarison Rose Marie Lutz Meredith Torti Valeria Tan Chia Bonadonna Giovanna Randrianambinina Blanchard Rasoloharijaona Solofonirina Rabarison Harison Miaretsoa Longondraza Rarojoson Nianja Jemisa De Gregorio Chiara Valente Daria Gamba Marco Ratsimbazafy Jonah Giacoma Cristina 《International journal of primatology》2022,43(4):584-610
International Journal of Primatology - Deforestation around the world is a major threat to primates. Understanding primate species’ habitat and dietary requirements is critical in creating... 相似文献
68.
Body‐mass‐dependent trade‐off between immune response and uropygial gland size in house sparrows Passer domesticus 下载免费PDF全文
Gregorio Moreno‐Rueda 《Journal of avian biology》2015,46(1):40-45
Parasites greatly impact host fitness. The immune system is fundamental to combat endoparasites, and survival increases with greater investment in immunity. Some ectoparasites, by contrast, are reportedly combated by the use of the uropygial gland, an organ exclusive to birds, which secretes an oily substance (preen oil) that is spread on plumage. However, both mounting an immune response against a parasite and producing uropygial gland secretion depend on the same resources, a situation which may induce trade‐offs between the two antiparasitic functions. In this study, I experimentally test whether immune response is traded off against uropygial gland size in the house sparrow Passer domesticus. In the experiment, a group of sparrows were injected with an antigen (lipopolysaccharide, LPS), which stimulates the immune system, while the other group received a sham injection. The uropygial gland of LPS‐treated birds decreased significantly more than that of the control birds after treatment. Nevertheless, the effect of the treatment was limited to house sparrows with low body mass, suggesting that heavy house sparrows were able to produce an immune response while maintaining a relatively large uropygial gland. Given that uropygial gland size is strongly related to production of preen oil, these results suggest that preen oil production declines in birds in poor body condition when resources are preferentially diverted to other demanding functions, such as the immune system. Considering that the uropygial gland is involved in several fitness‐related processes in birds, the trade‐off between immune response and uropygial gland size may have important consequences for bird life histories. 相似文献
69.
M. Luisa Molina A. Marcela Giudici José A. Poveda Gregorio Fernández-Ballester Estefanía Montoya M. Lourdes Renart Asia M. Fernández José A. Encinar Gloria Riquelme Andrés Morales José M. González-Ros 《The Journal of biological chemistry》2015,290(42):25745-25755
There is increasing evidence to support the notion that membrane proteins, instead of being isolated components floating in a fluid lipid environment, can be assembled into supramolecular complexes that take part in a variety of cooperative cellular functions. The interplay between lipid-protein and protein-protein interactions is expected to be a determinant factor in the assembly and dynamics of such membrane complexes. Here we report on a role of anionic phospholipids in determining the extent of clustering of KcsA, a model potassium channel. Assembly/disassembly of channel clusters occurs, at least partly, as a consequence of competing lipid-protein and protein-protein interactions at nonannular lipid binding sites on the channel surface and brings about profound changes in the gating properties of the channel. Our results suggest that these latter effects of anionic lipids are mediated via the Trp67–Glu71–Asp80 inactivation triad within the channel structure and its bearing on the selectivity filter. 相似文献
70.
Leto K Bartolini A Di Gregorio A Imperiale D De Luca A Parmigiani E Filipkowski RK Kaczmarek L Rossi F 《Development (Cambridge, England)》2011,138(16):3463-3472
The progenitors of cerebellar GABAergic interneurons proliferate up to postnatal development in the prospective white matter, where they give rise to different neuronal subtypes, in defined quantities and according to precise spatiotemporal sequences. To investigate the mechanisms that regulate the specification of distinct interneuron phenotypes, we examined mice lacking the G1 phase-active cyclin D2. It has been reported that these mice show severe reduction of stellate cells, the last generated interneuron subtype. We found that loss of cyclin D2 actually impairs the whole process of interneuron genesis. In the mutant cerebella, progenitors of the prospective white matter show reduced proliferation rates and enhanced tendency to leave the cycle, whereas young postmitotic interneurons undergo severe delay of their maturation and migration. As a consequence, the progenitor pool is precociously exhausted and the number of interneurons is significantly reduced, although molecular layer interneurons are more affected than those of granular layer or deep nuclei. The characteristic inside-out sequence of interneuron placement in the cortical layers is also reversed, so that later born cells occupy deeper positions than earlier generated ones. Transplantation experiments show that the abnormalities of cyclin D2(-/-) interneurons are largely caused by cell-autonomous mechanisms. Therefore, cyclin D2 is not required for the specification of particular interneuron subtypes. Loss of this protein, however, disrupts regulatory mechanisms of cell cycle dynamics that are required to determine the numbers of interneurons of different types and impairs their rhythm of maturation and integration in the cerebellar circuitry. 相似文献