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Mauricio Grecco Zaia Sandra Regina Pereira de Oliveira Cynthia Aparecida de Castro Edson Garcia Soares Ana Afonso Luis Gustavo S Monnazzi Oscar Peitl Filho Lúcia Helena Faccioli Fernanda de Freitas Anibal 《Memórias do Instituto Oswaldo Cruz》2015,110(6):726-731
The protective effect of infectious agents against allergic reactions has been
thoroughly investigated. Current studies have demonstrated the ability of some
helminths to modulate the immune response of infected hosts. The objective of the
present study was to investigate the relationship between Toxocara
canis infection and the development of an allergic response in mice
immunised with ovalbumin (OVA). We determined the total and differential blood and
bronchoalveolar lavage fluid cells using BALB/c mice as a model. To this end, the
levels of interleukin (IL)-4, IL-5 and IL-10 and anti-OVA-IgE were measured using an
ELISA. The inflammatory process in the lungs was observed using histology slides
stained with haematoxylin and eosin. The results showed an increase in the total
number of leukocytes and eosinophils in the blood of infected and immunised animals
at 18 days after infection. We observed a slight lymphocytic inflammatory infiltrate
in the portal space in all infected mice. Anti-OVA-IgE levels were detected in
smaller proportions in the plasma of immunised and infected mice compared with mice
that were only infected. Therefore, we concluded that T. canis
potentiates inflammation in the lungs in response to OVA, although anti-OVA-IgE
levels suggest a potential reduction of the inflammatory process through this
mechanism. 相似文献