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131.
132.
Fine structure of ribosomal RNA. III. Location of evolutionarily conserved regions within ribosomal DNA 总被引:11,自引:0,他引:11
In order to define functional regions within ribosomal RNA, we have identified areas of the molecule which have been conserved during evolution. Our previous studies showed that there is evolutionary conservation between the rRNAs of different eukaryotes and that the sequences conserved between distantly related species are a subset of those conserved between closely related species. In the present work, we have employed DNA-DNA and DNA-RNA hybridization techniques to localize these conserved regions to mapped restriction fragments 50 to 300 base-pairs in length within cloned Xenopus laevis ribosomal DNA. Our experiments have detected evolutionary conservation only within the coding regions, suggesting that if there is any conservation within the spacers, these sequences must be very short. Regions of conservation can be classified either by evolutionary distance or by the extent of conservation between two species. Three regions, including one near the 3' end of 18 S and two near the 3' end of 28 S rRNA are conserved over great evolutionary distance, that is between Escherichia coli and X. laevis. In addition, several fragments in the central portions of the 188 and 28 S rRNAs are exceptional in the extent of their conservation between yeast and Xenopus. We have been able to correlate the regions we have defined as conserved with certain structural or functional roles, such as initiation of translation, possible interaction with transfer RNA, rRNA methylation, and the site where intervening sequences interrupt some eukaryotic rRNAs. As a result, these studies serve to define relatively short (less than 300 base-pairs) segments within the almost 11,000 base X. laevis rDNA repeat unit which are worthy of further investigation. 相似文献
133.