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A. Chris Krueger John T. Randolph David A. DeGoey Pamela L. Donner Charles A. Flentge Douglas K. Hutchinson Dachun Liu Christopher E. Motter Todd W. Rockway Rolf Wagner David W.A. Beno Gennadiy Koev Hock B. Lim Jill M. Beyer Rubina Mondal Yaya Liu Warren M. Kati Kenton L. Longenecker Clarence J. Maring 《Bioorganic & medicinal chemistry letters》2013,23(12):3487-3490
The synthesis and structure–activity relationships of a novel aryl uracil series which contains a fused 5,6-bicyclic ring unit for HCV NS5B inhibition is described. Several analogs display replicon cell culture potencies in the low nanomolar range along with excellent rat pharmacokinetic values. 相似文献