全文获取类型
收费全文 | 171篇 |
免费 | 6篇 |
出版年
2019年 | 3篇 |
2017年 | 4篇 |
2015年 | 5篇 |
2014年 | 3篇 |
2013年 | 4篇 |
2012年 | 4篇 |
2011年 | 14篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 8篇 |
2007年 | 5篇 |
2006年 | 4篇 |
2005年 | 7篇 |
2004年 | 8篇 |
2003年 | 3篇 |
2002年 | 6篇 |
2000年 | 6篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1987年 | 3篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1968年 | 3篇 |
1960年 | 3篇 |
1958年 | 3篇 |
1955年 | 1篇 |
1953年 | 1篇 |
1946年 | 1篇 |
1943年 | 2篇 |
1942年 | 1篇 |
1941年 | 1篇 |
1940年 | 1篇 |
1939年 | 1篇 |
1938年 | 1篇 |
1936年 | 1篇 |
1934年 | 1篇 |
1933年 | 2篇 |
1932年 | 3篇 |
1931年 | 1篇 |
1930年 | 1篇 |
1929年 | 2篇 |
1928年 | 1篇 |
1927年 | 4篇 |
1926年 | 6篇 |
1925年 | 3篇 |
1924年 | 2篇 |
1922年 | 1篇 |
1890年 | 1篇 |
排序方式: 共有177条查询结果,搜索用时 390 毫秒
101.
Ott TR Pahuja A Nickolls SA Alleva DG Struthers RS 《The Journal of biological chemistry》2004,279(41):42383-42392
The binding pocket of family A GPCRs that bind small biogenic amines is well characterized. In this study we identify residues on CC chemokine receptor 7 (CCR-7) that are involved in agonist-mediated receptor activation but not in high affinity ligand binding. The mutations also affect the ability of the ligands to induce chemotaxis. Two of the residues, Lys3.33(137) and Gln5.42(227), are consistent with the binding pocket described for biogenic amines, while Lys3.26(130) and Asn7.32(305), are found at, or close to, the cell surface. Our observations are in agreement with findings from other peptide and chemokine receptors, which indicate that receptors that bind larger ligands contain contact sites closer to the cell surface in addition to the conventional transmembrane binding pocket. These findings also support the theory that chemokine receptors require different sets of interactions for high affinity ligand binding and receptor activation. 相似文献
102.
103.
David E. Ausband Michael S. Mitchell Sarah B. Bassing Andrea Morehouse Douglas W. Smith Daniel Stahler Jennifer Struthers 《Ethology : formerly Zeitschrift fur Tierpsychologie》2016,122(12):963-972
Variation in group composition and environment can affect helping behavior in cooperative breeders. Understanding of how group size, traits of individuals within groups, food abundance, and predation risk simultaneously influence helping behavior is limited. We evaluated pup‐guarding behavior in gray wolves (Canis lupus) to assess how differences in individuals, groups, and environment affect helping behavior. We used data from 92 GPS‐collared wolves in North America (2001–2012) to estimate individual pup‐guarding rates. Individuals in groups with low helper‐to‐pup ratios spent more time guarding young than those in groups with more helpers, an indication of load‐lightening. Female helpers guarded more than male helpers, but this relationship weakened as pups grew. Subset analyses including data on helper age and wolf and prey density showed such factors did not significantly influence pup‐guarding rates. We show that characteristics of individuals and groups have strong influences on pup‐guarding behavior in gray wolves, but environmental factors such as food abundance and predation risk from conspecifics were not influential. 相似文献
104.
We have used cysteine scanning mutagenesis and disulfide cross-linking in a split rhodopsin construct to investigate the secondary structure and tertiary contacts of the fifth (TM5) and sixth (TM6) transmembrane segments of rhodopsin. Using a simple increase in pH to promote disulfide bond formation, three cross-links between residues on the extracellular side of TM5 (at positions 198, 200, and 204) and TM6 (at position 276) have been identified and characterized. The helical pattern of cross-linking observed indicates that the fifth transmembrane helix extends through residue 200 but does not include residue 198. Rhodopsin mutants containing these disulfides demonstrate nativelike absorption spectra and light-dependent activation of transducin, suggesting that large movements on the extracellular side of TM5 with respect to TM6 are not required for receptor activation. 相似文献
105.
106.
107.
108.
109.
110.
In seasonal environments with limited time and energy resources, double‐brooded birds face trade‐offs in the timing of their two reproductive attempts and in the effort allocated to the first and the second broods. In the Barn Swallow Hirundo rustica a long care period for the first brood enhances the survival of first‐brood chicks, but also delays the start of the second brood, which in turn reduces the survival prospects of second‐brood chicks. Probably as a response to this trade‐off, double‐brooded Barn Swallows reduce the period of post‐fledging care for first‐brood fledglings. By radiotracking whole families, we investigated the determinants of this behaviour and its consequences for the survival of the first‐brood fledglings. The end of the females’ investment in post‐fledging care of the first brood was related to the beginning of egg synthesis for the second clutch. With the start of egg synthesis, females significantly reduced provisioning rates to the first‐brood fledglings to less than one‐fifth of the previous rates, while the proportion of time they spent foraging remained high. Assuming that the females’ foraging success was constant, we conclude that their energy income was allocated to egg production rather than fledgling provision. Males did not compensate for the females’ reduced feeding rates. Thus the start of egg production for the second clutch had a marked effect on the quantity of food received by first‐brood fledglings. In parallel with the changes in parental behaviour and provisioning rates, we observed a marked drop in the daily survival rate of first‐brood chicks. These results support the hypothesis that females face a strong trade‐off in the allocation of energy to subsequent broods. Energy allocation to a second clutch involves a cost in terms of reduced provisioning, and as a result the survival of first‐brood chicks is compromised. This is probably outweighed by the improved success of an early second brood. 相似文献