Lactate Dehydrogenase Is an Important Prognostic Indicator for Hepatocellular Carcinoma after Partial Hepatectomy

Preoperative serum lactate dehydrogenase (LDH) has been used as a prognostic indicator for patients with hepatocellular carcinoma (HCC) treated with sorafenib or undergoing transcatheter arterial chemoembolization, but its significance in predicting survival of HCC patients who received curative resection remains undefined. A total of 683 patients with histopathologically confirmed HCC were enrolled in this study. The prognostic significance of preoperative serum LDH was determined by Kaplan-Meier analysis and a Cox proportional hazards regression model. The association between the preoperative serum LDH and clinicopathological parameters was evaluated by the χ² test or linear regression analysis when appropriate. Higher preoperative serum LDH level was associated with worse prognosis. In a multivariate Cox proportional hazards analysis, the preoperative serum LDH level could predict overall survival and recurrence independently. Higher preoperative serum LDH level is associated with the elevated serum alpha-fetoprotein, the presence of hepatitis B surface antigen, larger tumor size, the presence of macrovascular invasion, the advanced tumor–lymph node–metastasis stage, worse tumor differentiation, and Child-Pugh B. Preoperative serum LDH level was an inexpensive, simple, convenient, and routinely measured biomarker exhibiting a potential to select patients at high risk with poor clinical outcome for appropriate treatment strategies.     

一些硬蜱的抗热性及其与表皮脂类关系

姜在阶(1973)曾对一些硬蜱在不同发育时期和不同生理状态下的抗热性特点及不同种类间的抗热性差异作过研究,提出可用硬蜱的抗热性作为鉴别物种的指标。一般认为,硬蜱的抗热性与保持水分平衡的表皮脂类密切相关。但是,关于蜱类表皮化学的研究,国内尚未见到报道。     

基于16S rDNA测序及培养基法探究虹鳟鱼贮藏优势腐败菌

为探究虹鳟鱼腐败机制,选取新鲜虹鳟鱼鱼片在0℃条件下进行贮藏.根据鱼肉样品的菌落总数和挥发性盐基氮(TVB-N)含量,确定虹鳟鱼鱼片的贮藏终点.利用传统培养基分离手段及16S rDNA高通量测序技术相结合的方法鉴定贮藏过程中的优势腐败菌.采用16S rDNA测序技术,对虹鳟鱼贮藏初期、中期及末期的腐败菌组成进行鉴定.1...     

美丽中国建设时空演变及耦合研究

美丽中国是党的"十八大"提出的新战略思想，也是生态文明建设发展的延续。本文以2000-2017年为研究时段，选取我国31个省、市、自治区为研究区域，借助GeoDa空间自相关分析及动静态耦合模型，探索我国美丽中国建设的时空分异规律、空间分布格局及系统耦合协调度。结果表明：①研究期内，我国美丽中国的发展呈波动上升趋势，且存在东部>西部>中部的空间分布特征。②我国美丽中国的发展格局稳定，但东西部地区两极分化问题严重；子系统中，除制度体系不显著外，均存在显著正向空间关联，且社会、经济、文化与环境高集聚区空间分布错位。③我国社会、环境、经济、文化、制度的静态耦合协调度呈波动上升趋势，东西部区域发展差异明显；动态耦合不及静态耦合协调水平，部分省市存在社会发展、绿色环境、经济增长、以及文化和制度发展受阻现象。