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81.
Unusual cultures of a Microsporum species were isolated from eleven patients who had either tinea capitis or tinea corporis or both. Although the macroconidia produced in the primary cultures resembled those of M. canis, hyphal morphology and colony characteristics were different from any of the more commonly occurring Microsporum species. Careful examination of subcultures showed that the isolates were composed of two species; M. canis and M. distortum, whose relationship remains enigmatic. 相似文献
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83.
Following the arrival of blue-tongue in Tunisia, the authors report the results of the first survey made in Monastir. They show the existence of nine species of Culicoides, three of which are new to the country IC. paolae, C. imicola, C. newsteadi), that now brings to 22 the number of the known species. 相似文献
84.
Saoussen Ben Abdallah Mokded Rabhi Faten Harbaoui Faten Zar-kalai Mokhtar Lachâal Najoua Karray-Bouraoui 《Acta Physiologiae Plantarum》2013,35(4):1161-1169
In the present work, we investigated the effect of salt stress on the distribution of safflower (Carthamus tinctorius L.) antioxidant system in relation to leaf age. The study was carried out under growth chamber conditions using seedlings of three cultivars which were subjected to 0 and 50 mM NaCl for 3 weeks. Leaf growth, water content, lipid peroxidation, and phenolic compound (total polyphenols, total flavonoids, and proanthocyanidins) concentration were measured at two leaf stages (young and old leaves). Leaf growth was affected by salinity only in Kairouan cultivar that also showed a significant decrease in old leaf water content. By contrast, Gabes and Tazarka cultivars maintained their old leaf water content constant and showed a reduction in that of young leaves. This could be attributed to a higher aptitude of the latter two cultivars to use absorbed sodium and chloride for osmotic adjustment in old leaves, keeping potassium for specific functions. Salt-induced lipid peroxidation was observed only in old leaves, whereas the accumulation of the major phenolic compounds under saline conditions was higher in young leaves, except in Gabes cultivar where no significant difference was found between the two leaf stages. A significant variability was also found between the three cultivars. The better behavior of salt-challenged leaves of Gabes and Tazarka cultivars compared to that of Kairouan cultivar may be related to their higher water content and the accumulation of polyphenols, in particular flavonoids that were shown to be efficiently involved in the restriction of salt-induced oxidative damages. 相似文献
85.
Ahlem Amouri Wajih Hammami Olfa Kilani Abderrezzak Bouzouita Wiem Ayed Mounir Ben Meftah Mohamed Khrouf Anis Fadhlaoui Sonia Abdelhak Fethi Zhioua Mohamed Habib Jaafoura 《Comptes rendus biologies》2014,337(4):223-228
Male infertility is the cause in half of all childless partnerships. Numerous factors contribute to male infertility, including chromosomal aberrations and gene defects. Few data exist regarding the association of these chromosomal aberrations with male infertility in Arab and North African populations. We therefore aimed to evaluate the frequency of chromosomal aberrations in a sample of 476 infertile men with non-obstructive azoospermia (n = 328) or severe oligozoospermia (n = 148) referred for routine cytogenetic analysis to the department of cytogenetics of the Pasteur Institute of Tunis. The overall incidence of chromosomal abnormalities was about 10.9%. Out of the 52 patients with abnormal cytogenetic findings, sex chromosome abnormalities were observed in 42 (80.7%) including Klinefelter syndrome in 37 (71%). Structural chromosome abnormalities involving autosomes (19.2%) and sex chromosomes were detected in 11 infertile men. Abnormal findings were more prevalent in the azoospermia group (14.02%) than in the severe oligozoospermia group (4.05%). The high frequency of chromosomal alterations in our series highlights the need for efficient genetic testing in infertile men, as results may help to determine the prognosis, as well as the choice of an assisted reproduction technique. Moreover, a genetic investigation could minimize the risk of transmitting genetic abnormalities to future generations. 相似文献
86.
Rocio T. Martinez-Nunez Victor P. Bondanese Fethi Louafi Ana S. Francisco-Garcia Hitasha Rupani Nicole Bedke Stephen Holgate Peter H. Howarth Donna E. Davies Tilman Sanchez-Elsner 《PloS one》2014,9(10)
MicroRNAs are short non-coding single stranded RNAs that regulate gene expression. While much is known about the effects of individual microRNAs, there is now growing evidence that they can work in co-operative networks. MicroRNAs are known to be dysregulated in many diseases and affect pathways involved in the pathology. We investigated dysregulation of microRNA networks using asthma as the disease model. Asthma is a chronic inflammatory disease of the airways characterized by bronchial hyperresponsiveness and airway remodelling. The airway epithelium is a major contributor to asthma pathology and has been shown to produce an excess of inflammatory and pro-remodelling cytokines such as TGF-β, IL-6 and IL-8 as well as deficient amounts of anti-viral interferons. After performing microRNA arrays, we found that microRNAs -18a, -27a, -128 and -155 are down-regulated in asthmatic bronchial epithelial cells, compared to cells from healthy donors. Interestingly, these microRNAs are predicted in silico to target several components of the TGF-β, IL-6, IL-8 and interferons pathways. Manipulation of the levels of individual microRNAs in bronchial epithelial cells did not have an effect on any of these pathways. Importantly, knock-down of the network of microRNAs miR-18a, -27a, -128 and -155 led to a significant increase of IL-8 and IL-6 expression. Interestingly, despite strong in silico predictions, down-regulation of the pool of microRNAs did not have an effect on the TGF-β and Interferon pathways. In conclusion, using both bioinformatics and experimental tools we found a highly relevant potential role for microRNA dysregulation in the control of IL-6 and IL-8 expression in asthma. Our results suggest that microRNAs may have different roles depending on the presence of other microRNAs. Thus, interpretation of in silico analysis of microRNA function should be confirmed experimentally in the relevant cellular context taking into account interactions with other microRNAs when studying disease. 相似文献
87.
Sukriye Ilkay Guner Savas Guner Erdal Peker Mehmet Fethi Ceylan Ayse Guler Ugur Turktas Barıs Kaki 《The Journal of membrane biology》2013,246(2):115-119
The purpose of this study was to investigate prospectively the effects of swaddling and consanguineous marriage on developmental dysplasia of the hip and associated risk factors. We screened by ultrasound 265 infants using the Graf method. The Pediatrics Department referred all newborn infants with suspected instability or a recognized risk factor to the orthopedic clinic. Risk factors of developmental dysplasia of the hip were searched and noted in these patients. Swaddling and consanguineous marriage were also determined and noted. We observed 164 of 265 infants (61.9 %) who had been swaddled and that 64 of 265 infants’ parents were in a consanguineous marriage (24.2 %). In the statistical analysis that was conducted for swaddling and consanguineous marriage, highly significant differences were found. Our study showed that the rate of developmental dysplasia of the hip is very high, 11.7 %, in our region, eastern Turkey. Also, we commonly see improper swaddling and consanguineous marriage in our region, which affects many infants. 相似文献
88.
Najoua Karray-Bouraoui Faten Harbaoui Mokded Rabhi Inès Jallali Riadh Ksouri Houneida Attia Najoua Msilini Mokhtar Lachaâl 《Acta Physiologiae Plantarum》2011,33(4):1435-1444
Seedlings of two Tunisian Carthamus tinctorius L. provenances (Kairouan and Tazarka) differing in salt sensitivity were hydroponically grown at 0 and 50 mM NaCl over 21 days.
Leaves of Kairouan (salt-sensitive) showed a 48% restriction in their growth at 50 mM NaCl although they accumulated less
sodium than those of Tazarka (less salt-sensitive) that maintained an unchanged growth. Salt treatment induced oxidative stress
in C. tinctorius and the effect was more pronounced in the leaves of the more salt sensitive provenance, Kairouan. Both provenances exhibited
a stimulation of antioxidant enzyme activities with higher catalase (CAT) and superoxide dismutase (SOD) activities in Tazarka
and higher peroxidase (POD) activity in Kairouan. But, it seems that antioxidant activities were more correlated with polyphenol
content. Actually, leaves of Tazarka experienced higher polyphenol and antioxidant activity than Kairouan at 50 mM NaCl. Hence,
moderate salinity (3 g NaCl L−1) enhanced bioactive molecule yield in the less salt sensitive provenance, Tazarka. In addition, C. tinctorius was found rich in ascorbic acid, but the moderate salt stress enhanced its production only in the sensitive provenance. 相似文献
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Nawel Nasri Rym Kaddour Mokded Rabhi Claude Plassard Mokhtar Lachaal 《Acta Physiologiae Plantarum》2011,33(3):935-942
Seeds of four lettuce (Lactuca sativa L.) varieties (Romaine, Augusta, Vista and Verte) differing in their salt sensitivity were sown at 0 (Control), 50, 100 and
150 mM NaCl. The final germination percentage decreased with the increasing salinity and was annulated at the highest salt
concentration in Vista and Verte, the most sensitive varieties. However, in the less sensitive ones, Romaine and Augusta, it was slightly modified at 50 and 100 mM NaCl and then decreased by 50% compared with the control, at 150 mM. The effects
of NaCl 100 mM on seedling growth, phytase activities, phytate and inorganic phosphorus contents were studied in Romaine and Vista showing different behaviours towards salinity. Radicle and hypocotyl length and fresh and dry weights were reduced by salt
treatment in both varieties. In addition, radicle phytase activity exhibited an increase in Romaine (less sensitive) and a decrease in Vista (more sensitive). In hypocotyl, this activity showed no difference with the control in the two varieties. However, in cotyledons,
and during early hours after germination, salinity decreased phytase activity in both varieties whereas in the later hours
(72–96 h) this activity reached the value of the control in Romaine. The enhancement of phytase activity was concomitant with an increase in orthophosphate content and a decrease in phytate
reserve. These results suggest that salt presence in the medium delays Pi remobilization from phytate stock, but stimulates
assimilation of phosphorus more than its accumulation in the organs of the two lettuce varieties. 相似文献