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991.
The bacteriophage BA3 multiplies in and lyses the coral pathogen Thalassomonas loyana. The complete genome of phage BA3 was sequenced; it contains 47 open reading frames with a 40.9% G + C content. Phage BA3
adsorbed to its starved host in seawater with a k = 1.0 × 10−6 phage ml−1 min−1. Phage therapy of coral disease in aquarium experiments was successful when the phage was added at the same time as the pathogen
or 1 day later, but failed to protect the coral when added 2 days after bacterial infection. When the phages were added 1 day
after coral infection, the phage titer increased about 100-fold and remained present in the aquarium water throughout the
37-day experiment. At the end of the experiment, the concentration of phages associated with the corals was 2.5 ± 0.5 × 104 per cm2 of coral surface. Corals that were infected with the pathogen and treated with phage did not transmit the disease to healthy
corals. 相似文献
992.
Mark Eugene Mort Christopher P. Randle Priscilla Burgoyne Gideon Smith Ernst Jaarsveld Stephen D. Hopper 《Plant Systematics and Evolution》2009,283(3-4):211-217
Analysis of cpDNA matK sequences for a total of 43 members of the succulent plant family Crassulaceae, including 24 taxa of Crassula, recovered a well-supported clade comprising Crassula species that is sister to the remainder of the family. The resulting topologies do not support the monophyly of the currently recognized subgenera of Crassula, as one member of subgenus Disporocarpa (C. crenulata) is placed as sister to an otherwise monophyletic subgenus Crassula. The major synapomorphy that has been used to recognize the latter subgenus is a base chromosome number of x = 7 versus a base of x = 8 in the other subgenus. We cannot assess the utility of this feature for defining subgenus Crassula because a chromosome count of C. crenulata has yet to be published. The five accessions of the recently resurrected segregate genus Tillaea (of 24 total Crassula species) included here were placed in four separate, well-supported lineages, one of which is greatly removed from the other four accessions. This suggests that this genus is not valid and should not be recognized. An initial examination of the evolution of habit indicates that a perennial habit is ancestral and that the annual habit is a feature that has been derived at least twice in the genus. 相似文献
993.
Yonghui Wang Chaya Duraiswami Kevin P. Madauss Thuy B. Tran Shawn P. Williams Su-Jun Deng Todd L. Graybill Marlys Hammond David G. Jones Eugene T. Grygielko Jeffrey D. Bray Scott K. Thompson 《Bioorganic & medicinal chemistry letters》2009,19(17):4916-4919
High throughput screening of the corporate compound collection led to the identification of a novel series of 2-amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2′,3′:4,5]thieno[2,3-b]pyridine derivatives as selective PR agonists. Initial SAR exploration leading to potent and selective agonists 9 and 11, X-ray crystal structure of 9 bound to PR-LBD and preliminary developability data are described. 相似文献
994.
David G. Washburn Tram H. Hoang James S. Frazee Latisha Johnson Marlys Hammond Sharada Manns Kevin P. Madauss Shawn P. Williams Chaya Duraiswami Thuy B. Tran Eugene L. Stewart Eugene T. Grygielko Lindsay E. Glace Walter Trizna Rakesh Nagilla Jeffrey D. Bray Scott K. Thompson 《Bioorganic & medicinal chemistry letters》2009,19(16):4664-4668
We have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR selectivity, rat pharmacokinetic properties, and in vivo potency compared to the lead compound. In addition, these compounds had improved selectivity against hERG channel inhibition. 相似文献
995.
An T. Vu Stephen T. Cohn Eugene A. Terefenko William J. Moore Puwen Zhang Paige E. Mahaney Eugene J. Trybulski Igor Goljer Rebecca Dooley Jenifer A. Bray Grace H. Johnston Jennifer Leiter Darlene C. Deecher 《Bioorganic & medicinal chemistry letters》2009,19(9):2464-2467
A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter. 相似文献
996.
Weinberg ED 《Biochimica et biophysica acta》2009,1790(7):600-605
997.
998.
Background
The prokaryotic toxin-antitoxin systems (TAS, also referred to as TA loci) are widespread, mobile two-gene modules that can be viewed as selfish genetic elements because they evolved mechanisms to become addictive for replicons and cells in which they reside, but also possess "normal" cellular functions in various forms of stress response and management of prokaryotic population. Several distinct TAS of type 1, where the toxin is a protein and the antitoxin is an antisense RNA, and numerous, unrelated TAS of type 2, in which both the toxin and the antitoxin are proteins, have been experimentally characterized, and it is suspected that many more remain to be identified. 相似文献999.