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Raeisi Farzaneh Abolfathi Mahdieh Ahmadi-Naji Raheleh Iranparast Sara Noshadi Esmat Akbari Arvand Mahmoudi Esmaeil Khaledi Mansoor Arshi Asghar 《Molecular biology reports》2019,46(1):77-82
Molecular Biology Reports - Important regulatory roles of long non-coding RNAs (lncRNAs) have been recently found, and reported as useful biomarkers in cancer. To identify a potential expression of... 相似文献
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Asma Mohammadi Ali Reza Balizadeh Karami Seyyed Ali Mard Gholamreza Goudarzi Heidar Maleki Narges Chamkouri Sara Mobarak Esmat Radmanesh 《Reports of Biochemistry & Molecular Biology》2021,10(2):334
Background:The effect of total suspended particulate matter (TSP) was investigated on the expression of inflammatory and apoptotic factors in diabetic rats, and the effect of crocin and insulin was examined on these factors.Methods:Fifty-four adult male wistar rats were divided into nine experimental groups: control group, crocin group (received crocin, 50 mg/kg), diabetic group (received a single dose of alloxan at 120 mg/kg, IP), TSP group (5 mg/kg TSP instilled intratracheally), diabetic-crocin group (received crocin at 50 mg/kg after the induction of diabetes by alloxan (120 mg/kg)), diabetic-insulin group (received regular insulin (5 U/kg), crocin-TSP group (received crocin at 50 mg/kg, IP, and then 5 mg/kg TSP was instilled intratracheally), diabetic-TSP-insulin group (after receiving alloxan (120 mg/kg) and instilling TSP (5 mg/kg, intratracheally), a single dose (5 U/kg) of regular insulin), and diabetic-TSP-crocin group (after receiving alloxan (120 mg/kg) and instilling TSP (5 mg/kg, intratracheally), a single dose of crocin (50 mg/kg, IP)). Quantitative real-time PCR was performed to measure the expression of the mRNAs of apoptotic (Bax and Bcl2) and inflammatory mediators (TNFα, COX2, iNOS/eNOS) in Wistar rats.Results:In diabetic and TSP groups the inflammatory factors and BAX/Bcl2 ratio significantly increased compared to the control group. In diabetic-TSP-insulin and diabetic-TSP-crocin, a significant decrease was observed in the rate of inflammatory factors and BAX/Bcl2 ratio.Conclusion:The results suggested that diabetes and exposure to TSP increase the rate of apoptosis and inflammation, and also demonstrated the anti-apoptotic and anti-inflammation role of insulin and crocin.Key Words: Apoptosis, Crocin, Diabetes, Inflammation, Insulin, TSP 相似文献
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Nader R. Abdelsalam Wafaa E. Grad Nabawya S.A. Ghura Ahmed E. Khalid Rehab Y. Ghareeb El-Sayed M. Desoky Mostafa M. Rady Hatim M. Al-Yasi Esmat F. Ali 《Saudi Journal of Biological Sciences》2021,28(12):7432-7442
Tissue culture methods are useful in assessing the tolerance of various stresses due to the ease of controlling stress under in vitro conditions. This study aimed to investigate the response of sugarcane genotyps to drought stress using calli as a model system. For inducing sugarcane callus, the medium of Murashige and Skoog (MS) was used with different mannitol concentrations (100, 200, and 300 mM) to measure their effects on callus frequency, the day of callus initiation, embryogenic potential, relative growth rate (RGR), water and proline contents, K+ and Na+ contents, as well as the formation of shoot and roots for three sugarcane genotypes (e.g., GT 54-9, G 84-47, and pH 8013). The RAPD-PCR analysis was carried out using five oligonucleotide primers to identify the genetic variation among sugarcane genotypes. The results indicated that the degree of callus proliferation varied from 70 − 86%. The highest value of callus proliferation, PGR, shoot formation was recorded for the genotype GT 54-9 compared to the other two genotypes (G 84-47 and pH 8013). Calli treated with 100 mM mannitol showed the highest RGR, proline and waer contents for the genotype GT 54-9, while, those treated with 300 mM recorded the lowest values of these parameters for the genotype pH 8013. The genotype G 84-47 collected highest Na+ content, while the genotype pH 8013 collected highest K+ content. The results of this study recommend preference for GT 54-9 genotype, which is considered the most promising genotype, showing more tolerance to drought stress based on all studied traits. 相似文献
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Alexis B. Lyons Deepti Ghia Marwa Abdallah Zalfa Abdel‐Malek Samia Esmat Khaled Ezzedine Pearl Grimes John E. Harris Harvey Lui Prashiela Manga Qing‐Sheng Mi Amit Pandya Davinder Parsad Thiery Passeron Mauro Picardo Julien Seneschal Narumol Silpa‐Archa Alain Taieb Flora Xiang Henry W. Lim Iltefat H. Hamzavi 《Pigment cell & melanoma research》2020,33(4):637-641
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Karamali Maryam Dastyar Fatemeh Badakhsh Mohammad Hossein Aghadavood Esmat Amirani Elaheh Asemi Zatollah 《Biological trace element research》2020,193(1):1-6
Biological Trace Element Research - To observe and compare the effects of healthy instruction and Zhiqi granules on lead, calcium, iron, and zinc levels in serum of children with moderately... 相似文献
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Youssef-Elabd EM McGee KC Tripathi G Aldaghri N Abdalla MS Sharada HM Ashour E Amin AI Ceriello A O'Hare JP Kumar S McTernan PG Harte AL 《The Journal of nutritional biochemistry》2012,23(1):39-50
A post-prandial increase in saturated fatty acids (SFAs) and glucose (Glc) activates an inflammatory response, which may be prolonged following restoration of physiological SFAs and Glc levels — a finding referred to as ‘metabolic memory'.This study examined chronic and oscillating SFAs and Glc on the inflammatory signalling pathway in human adipose tissue (AT) and adipocytes (Ads) and determined whether Ads are subject to “metabolic memory.”Abdominal (Abd) subcutaneous (Sc) explants and Ads were treated with chronic low glucose (L-Glc): 5.6 mM and high glucose (H-Glc): 17.5 mM, with low (0.2 mM) and high (2 mM) SFA for 48 h. Abd Sc explants and Ads were also exposed to the aforementioned treatment regimen for 12-h periods, with alternating rest periods of 12 h in L-Glc.Chronic treatment with L-Glc and high SFAs, H-Glc and high SFAs up-regulated key factors of the nuclear factor-κB (NFκB) pathway in Abd Sc AT and Ads (TLR4, NFκB; P<.05), whilst down-regulating MyD88. Oscillating Glc and SFA concentrations increased TLR4, NFκB, IKKβ (P<.05) in explants and Ads and up-regulated MyD88 expression (P<.05). Both tumor necrosis factor α and interleukin 6 (P<.05) secretion were markedly increased in chronically treated Abd Sc explants and Ads whilst, with oscillating treatments, a sustained inflammatory effect was noted in absence of treatment.Therefore, SFAs may act as key instigators of the inflammatory response in human AT via NFκB activation, which suggests that short-term exposure of cells to uncontrolled levels of SFAs and Glc leads to a longer-term inflammatory insult within the Ad, which may have important implications for patients with obesity and Type 2 diabetes. 相似文献