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531.
Edoardo Beretta Fortunata Solimano Yasuhiro Takeuchi 《Journal of mathematical biology》1996,35(1):1-19
A mathematical model for the delivery of drug directly to the macrophages by using the phagocytosis of senescent red blood
cells is proposed. The model is based on the following assumption: At time t=0 a preassigned red blood cell population n(0, a)=φ(a), a>0, loaded by the drug, is injected in the blood circulation. Among the cells of that population only those with an age a≧ā (ā=120 days) will be phagocytosed by macrophages. Of course, the lifetime of the drug must be higher than ā. Within the
red blood cells it cannot be metabolized, neither can it diffuse through their membranes. The emphasis of the paper is on
the mathematical properties and on the formulation of the control problem.
Received 15 December 1994; received in revised form 20 July 1995 相似文献
532.
Preserved ascomatal and other fungal structures on the remains of a ninth century Longobard abbess exhumed from a Monastery in Pavia,Italy 总被引:1,自引:0,他引:1
Auxarthron californiense, Mixotrichum aeruginosum, Oncocladium flavum and Chaetomium elatum were recognized on the basis of
ascomatal structures on the remains of a Longobard abbess who died in the IX century A.D. These fungi, which had remained
isolated in a crypt of the S. Felice Monastery of Pavia for almost 1000 years, are phenotypically identical to the type specimens.
The occurrence of these fungi and their ecological role are discussed.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
533.
Aminoglycoside antibiotics that bind to the ribosomal A site cause misreading of the genetic code and inhibit translocation. The clinically important aminoglycoside, gentamicin C, is a mixture of three components. Binding of each gentamicin component to the ribosome and to a model RNA oligonucleotide was studied biochemically and the structure of the RNA complexed to gentamicin C1a was solved using magnetic resonance nuclear spectroscopy. Gentamicin C1a binds in the major groove of the RNA. Rings I and II of gentamicin direct specific RNA-drug interactions. Ring III of gentamicin, which distinguishes this subclass of aminoglycosides, also directs specific RNA interactions with conserved base pairs. The structure leads to a general model for specific ribosome recognition by aminoglycoside antibiotics and a possible mechanism for translational inhibition and miscoding. This study provides a structural rationale for chemical synthesis of novel aminoglycosides. 相似文献