全文获取类型
收费全文 | 526篇 |
免费 | 85篇 |
出版年
2016年 | 8篇 |
2015年 | 11篇 |
2013年 | 13篇 |
2012年 | 15篇 |
2011年 | 9篇 |
2010年 | 8篇 |
2009年 | 13篇 |
2008年 | 17篇 |
2007年 | 18篇 |
2006年 | 8篇 |
2005年 | 19篇 |
2004年 | 19篇 |
2003年 | 12篇 |
2002年 | 14篇 |
2001年 | 11篇 |
2000年 | 14篇 |
1999年 | 11篇 |
1997年 | 9篇 |
1996年 | 7篇 |
1995年 | 6篇 |
1994年 | 6篇 |
1993年 | 7篇 |
1992年 | 14篇 |
1991年 | 13篇 |
1990年 | 16篇 |
1989年 | 21篇 |
1988年 | 22篇 |
1987年 | 18篇 |
1986年 | 19篇 |
1985年 | 23篇 |
1984年 | 14篇 |
1983年 | 13篇 |
1982年 | 10篇 |
1981年 | 12篇 |
1980年 | 7篇 |
1979年 | 12篇 |
1978年 | 9篇 |
1977年 | 11篇 |
1976年 | 11篇 |
1975年 | 13篇 |
1974年 | 10篇 |
1973年 | 8篇 |
1972年 | 6篇 |
1971年 | 13篇 |
1970年 | 11篇 |
1969年 | 5篇 |
1968年 | 14篇 |
1967年 | 6篇 |
1966年 | 4篇 |
1965年 | 5篇 |
排序方式: 共有611条查询结果,搜索用时 62 毫秒
91.
Edelman AJ 《PloS one》2012,7(2):e30914
Facilitation, when one species enhances the environment or performance of another species, can be highly localized in space. While facilitation in plant communities has been intensely studied, the role of facilitation in shaping animal communities is less well understood. In the Chihuahuan Desert, both kangaroo rats and harvester ants depend on the abundant seeds of annual plants. Kangaroo rats, however, are hypothesized to facilitate harvester ants through soil disturbance and selective seed predation rather than competing with them. I used a spatially explicit approach to examine whether a positive or negative interaction exists between banner-tailed kangaroo rat (Dipodomys spectabilis) mounds and rough harvester ant (Pogonomyrmex rugosus) colonies. The presence of a scale-dependent interaction between mounds and colonies was tested by comparing fitted spatial point process models with and without interspecific effects. Also, the effect of proximity to a mound on colony mortality and spatial patterns of surviving colonies was examined. The spatial pattern of kangaroo rat mounds and harvester ant colonies was consistent with a positive interspecific interaction at small scales (<10 m). Mortality risk of vulnerable, recently founded harvester ant colonies was lower when located close to a kangaroo rat mound and proximity to a mound partly predicted the spatial pattern of surviving colonies. My findings support localized facilitation of harvester ants by kangaroo rats, likely mediated through ecosystem engineering and foraging effects on plant cover and composition. The scale-dependent effect of kangaroo rats on abiotic and biotic factors appears to result in greater founding and survivorship of young colonies near mounds. These results suggest that soil disturbance and foraging by rodents can have subtle impacts on the distribution and demography of other species. 相似文献
92.
Background
The trafficking of mitochondria within neurons is a highly regulated process. In an earlier study, we found that serotonin (5-HT), acting through the 5-HT1A receptor subtype, promotes axonal transport of mitochondria in cultured hippocampal neurons by increasing Akt activity, and consequently decreasing glycogen synthase kinase (GSK3β) activity. This finding suggests a critical role for neuromodulators in the regulation of mitochondrial trafficking in neurons. In the present study, we investigate the effects of a second important neuromodulator, dopamine, on mitochondrial transport in hippocampal neurons.Methodology/Principal Findings
Here, we show that dopamine, like 5-HT, regulates mitochondrial motility in cultured hippocampal neurons through the Akt-GSK3β signaling cascade. But, in contrast to the stimulatory effect of 5-HT, administration of exogenous dopamine or bromocriptine, a dopamine 2 receptor (D2R) agonist, caused an inhibition of mitochondrial movement. Moreover, pretreatment with bromocriptine blocked the stimulatory effect of 5-HT on mitochondrial movement. Conversely, in cells pretreated with 5-HT, no further increases in movement were observed after administration of haloperidol, a D2R antagonist. In contrast to the effect of the D2R agonist, addition of , a dopamine 1 receptor (D1R) agonist, promoted mitochondrial transport, indicating that the inhibitory effect of dopamine was actually the net summation of opposing influences of the two receptor subtypes. The most pronounced effect of dopamine signals was on mitochondria that were already moving directionally. Western blot analysis revealed that treatment with either a D2R agonist or a D1R antagonist decreased Akt activity, and conversely, treatment with either a D2R antagonist or a D1R agonist increased Akt activity. SKF38393Conclusions/Significance
Our observations strongly suggest a role for both dopamine and 5-HT in regulating mitochondrial movement, and indicate that the integrated effects of these two neuromodulators may be important in determining the distribution of energy sources in neurons. 相似文献93.
94.
95.
G. M. Edelman 《Genetics》1994,138(4):975-981
96.
97.
98.
99.
A novel metabolic form of the 32 kDa-D1 protein in the grana-localized reaction center of photosystem II 总被引:6,自引:0,他引:6
F E Callahan M L Ghirardi S K Sopory A M Mehta M Edelman A K Mattoo 《The Journal of biological chemistry》1990,265(26):15357-15360
Two forms of the 32 kDa-D1 reaction center protein of photosystem II (PSII), having slightly different mobilities on denaturing polyacrylamide gels, have been resolved in Spirodela oligorrhiza, Glycine max L., Gossypium hirsutum L., Triticum aestivum L., and Zea mays L. The protein band with faster mobility is identified as the 32 kDa-D1 protein, and the less mobile band as a novel form, designated 32*. The two forms are structurally similar based on immunological and partial proteolytic tests. 32* is associated exclusively with the grana and is present in the PSII reaction center. Temporally, 32* appears several hours after the translocation of newly synthesized and processed 32 kDa-D1 protein from the stroma lamellae to the grana. Formation of the 32* is strictly light-dependent under physiological light intensities and correlates with a reciprocal loss of the 32-kDa form. Light induced formation of 32* is inhibited by 3-(3,4-dichlorophenyl)-1,1-dimethylurea but is not coupled to linear electron transport. 相似文献
100.
Dan P. Zandberg Sandra Rollins Olga Goloubeva Robert E. Morales Ming Tan Rodney Taylor Jeffrey S. Wolf Lisa M. Schumaker Kevin J. Cullen Ann Zimrin Robert Ord Joshua E. Lubek Mohan Suntharalingam John C. Papadimitriou Dean Mann Scott E. Strome Martin J. Edelman 《Cancer immunology, immunotherapy : CII》2015,64(3):367-379