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671.
Dimitri Kadanoff 《Cell and tissue research》1928,6(5):631-636
Ohne Zusammenfassung 相似文献
672.
Dr. Giancarlo Pizza Francesco Chiodo Vincenzo Colangeli Francesco Gritti Enzo Raise Hugh H. Fudenberg Caterina De Vinci Dimitri Viza 《Biotherapy》1996,9(1-3):41-47
Twenty five HIV-1-infected patients, at various stages (CDC II, III and IV) were treated orally with HIV-1-specific transfer
factor (TF) for periods varying from 60 to 1870 days. All patients were receiving antiviral treatments in association with
TF. The number of lymphocytes, CD4 and CD8 subsets were followed and showed no statistically significant variations. In 11/25
patients the number of lymphocytes increased, whilst in 11/25 decreased; similarly an increase of the CD4 lymphocytes was
observed in 11/25 patients and of the CD8 lymphocytes in 15/25. Clinical improvement or a stabilized clinical condition was
noticed in 20/25 patients, whilst a deterioration was seen in 5/25. In 12/14 anergic patients, daily TF administration restored
delayed type hypersensitivity to recall antigens within 60 days. These preliminary observations suggest that oral HIV-specific
TF administration, in association with antiviral drugs, is well tolerated and seems beneficial to AIDS patients, thus warranting
further investigation. 相似文献
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Thiago Roberto Lima Romero Daniela da Fonseca Pacheco Igor Dimitri Gama Duarte 《Life sciences》2013,92(14-16):815-820
AimsRecently, we demonstrated that peripheral antinociception induced by δ opioid receptor is dependent of Ca2 +-activated Cl? channels (CaCCs). Because opioid and cannabinoid receptors share some common mechanisms of action, our objective was to identify a possible relationship between CaCCs and the endocannabinoid system.Main methodsTo induce hyperalgesia, rat paws were treated with intraplantar prostaglandin E2 (PGE2, 2 μg). Nociceptive thresholds to pressure (grams) were measured using an algesimetric apparatus 3 h following injection. Probabilities were calculated using ANOVA/Bonferroni's test, and values that were less than 5% were considered to be statistically significant.Key findingsAdministration of the cannabinoid agonist CB1 anandamide (12.5, 25 and 50 μg/paw) and the cannabinoid agonist CB2 PEA (5, 10 and 20 μg/paw) decreased the PGE2-induced hyperalgesia in a dose-dependent manner. The possibility of the higher doses of anandamide (50 μg) and PEA (20 μg) having a central or systemic effect was excluded because the administration of the drug into the contralateral paw did not elicit antinociception in the right paw. As expected, the antinociceptive effects induced by anandamide and PEA were blocked by the CB1 and CB2 receptor antagonists AM251 and AM630, respectively. The peripheral antinociception was induced by anandamide but not PEA and was dose-dependently inhibited by the CaCC blocker niflumic acid (8, 16 and 32 μg).SignificanceThese results provide the first evidence for the involvement of CaCCs in the peripheral antinociception induced by activation of the CB1 cannabinoid receptor. 相似文献
676.
Dr. Giancarlo Pizza Caterina De Vinci Vittorio Fornarola Aldopaolo Palareti Olavio Baricordi Dimitri Viza 《Biotherapy》1996,9(1-3):175-185
153 patients suffering from recurrent pathologies, i.e. viral infections (keratitis, keratouveitis, genital and labial herpes)
uveitis, cystitis, and candidiasis were treated with in vitro produced transfer factor (TF) specific for HSV-1/2, CMV and
Candida albicans. The cell-mediated immunity of seropositive patients to HSV-1/2 and/or CMV viruses was assessed using the
leucocyte migration inhibition test (LMT) and lymphocyte stimulation test (LST) in presence of the corresponding antigens,
and the frequency of positive tests before, during and after TF administration was studied. The data were stratified per type
of test, antigen and the recipients’ pathology, and statistically evaluated. For the LMT, a total of 960 tests were carried
out for each antigen dilution, 3 different antigen dilutions were used per test. 240/960 tests (25.4%) were found positive
during non-treatment or treatment with unspecific TF, whereas 147/346 tests (42.5%) were found positive when the antigen corresponding
to the specificity of the TF administered to the patient was used (P<0.001). When the data were stratified following pathology,
a significant increased incidence of positive tests during specific treatment was also observed (0.0001<P<0.05). In the LST
(1174 tests), a significant increase of thymidine uptake was observed in the absence of antigen (control cultures), during
treatment with both specific and unspecific TF, but also in the presence of antigen and/or autologous serum during specific
TF administration (P<0.0001). TF administration also significantly increased the soluble HLA class I antigens level in 40
patients studied to this effect. 相似文献
677.
The ‘communication through coherence’ (CTC) hypothesis proposes that selective communication among neural networks is achieved by coherence between firing rate oscillation in a sending region and gain modulation in a receiving region. Although this hypothesis has stimulated extensive work, it remains unclear whether the mechanism can in principle allow reliable and selective information transfer. Here we use a simple mathematical model to investigate how accurately coherent gain modulation can filter a population-coded target signal from task-irrelevant distracting inputs. We show that selective communication can indeed be achieved, although the structure of oscillatory activity in the target and distracting networks must satisfy certain previously unrecognized constraints. Firstly, the target input must be differentiated from distractors by the amplitude, phase or frequency of its oscillatory modulation. When distracting inputs oscillate incoherently in the same frequency band as the target, communication accuracy is severely degraded because of varying overlap between the firing rate oscillations of distracting inputs and the gain modulation in the receiving region. Secondly, the oscillatory modulation of the target input must be strong in order to achieve a high signal-to-noise ratio relative to stochastic spiking of individual neurons. Thus, whilst providing a quantitative demonstration of the power of coherent oscillatory gain modulation to flexibly control information flow, our results identify constraints imposed by the need to avoid interference between signals, and reveal a likely organizing principle for the structure of neural oscillations in the brain. 相似文献
678.
Romain Bekale Be Ndong Dimitri Hassan Oliul Kim Ju Sung Chang Taehyun 《Molecular biology reports》2022,49(1):413-420
Molecular Biology Reports - A new species within the genus Alternaria was isolated from the leaf spot of Atractylodes ovata in the Mungyeong and Hwabuk-myeon districts of the Gyeongbuk province of... 相似文献
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The “Earth of fortified settlement” is one of the last big discoveries of the end of the XXth century. Situated on the oriental slopes of the mounts of Ural, fortified settlement, date the Middle Bronze Age. These strengthened structures are particular in the archaeology of steppes. They were built according to geometrical plans, Cities in oval being the most ancient, the rectangular cities being the most recent. The most remarkable are together of strengthened structures appropriate for the culture of Sintachta-Arkaïm. This city distinguishes itself from the others by the unique integrity of the works of fortification and by the graves which are connected to these last ones. Situated on a prominence, Arkaim consists of two defensive walls, maybe of a third, the rampart and the ditch. The space between the defensive walls was occupied by the houses of shape trapezoidale and directed as beams to the center of the city. The center of the city, the rectangular shape, was not built and formed a place where foyers were found. Complex entrances were at the four corner of the city. The excavations of fortified settlement and graves allowed to have an idea on the level of development of the everyday life at the time of the Middle Bronze Age in transouraliennes plains. 相似文献