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91.
Ly Diane Dongol Anjila Cuthbertson Peter Guy Thomas V. Geraghty Nicholas J. Sophocleous Reece A. Sin Lucia Turner Bradley J. Watson Debbie Yerbury Justin J. Sluyter Ronald 《Purinergic signalling》2020,16(1):109-122
Purinergic Signalling - The ATP-gated P2X7 ion channel has emerging roles in amyotrophic lateral sclerosis (ALS) progression. Pharmacological blockade of P2X7 with Brilliant Blue G can ameliorate... 相似文献
92.
93.
Emma A. Elliott Smith Martin Tim Tinker Emily L. Whistler Douglas J. Kennett Ren L. Vellanoweth Diane Gifford‐Gonzalez Mark G. Hylkema Seth D. Newsome 《Ecology and evolution》2020,10(7):3318-3329
The sea otter (Enhydra lutris) is a marine mammal hunted to near extinction during the 1800s. Despite their well‐known modern importance as a keystone species, we know little about historical sea otter ecology. Here, we characterize the ecological niche of ancient southern sea otters (E. lutris nereis) using δ13C analysis and δ15N analysis of bones recovered from archaeological sites spanning ~7,000 to 350 years before present (N = 112 individuals) at five regions along the coast of California. These data are compared with previously published data on modern animals (N = 165) and potential modern prey items. In addition, we analyze the δ15N of individual amino acids for 23 individuals to test for differences in sea otter trophic ecology through time. After correcting for tissue‐specific and temporal isotopic effects, we employ nonparametric statistics and Bayesian niche models to quantify differences among ancient and modern animals. We find ancient otters occupied a larger isotopic niche than nearly all modern localities; likely reflecting broader habitat and prey use in prefur trade populations. In addition, ancient sea otters at the most southerly sites occupied an isotopic niche that was more than twice as large as ancient otters from northerly regions. This likely reflects greater invertebrate prey diversity in southern California relative to northern California. Thus, we suggest the potential dietary niche of sea otters in southern California could be larger than in central and northern California. At two sites, Año Nuevo and Monterey Bay, ancient otters had significantly higher δ15N values than modern populations. Amino acid δ15N data indicated this resulted from shifting baseline isotope values, rather than a change in sea otter trophic ecology. Our results help in better understanding the contemporary ecological role of sea otters and exemplify the strength of combing zooarchaeological and biological information to provide baseline data for conservation efforts. 相似文献
94.
Jenna E. Stanek Shannon E. Mcneil Diane Tracy John R. Stanek Jeffrey A. Manning Murrelet D. Halterman 《The Journal of wildlife management》2021,85(4):782-793
The western distinct population segment of yellow-billed cuckoo (Coccyzus americanus; western cuckoo) has been extirpated from most of its former breeding range in the United States because of widespread loss and degradation of riparian cottonwood (Populus spp.)-willow (Salix spp.) forests. Restoration and management of breeding habitat is important to the recovery of this federally threatened species, and identification of high-quality breeding habitat can help improve the success of recovery. In 2005, the Lower Colorado River Multi-Species Conservation Program, a long-term, multi-agency effort, was initiated to maintain and create wildlife habitat within the historical floodplain of the lower Colorado River (LCR) for federally endangered and threatened species, including western cuckoos. We conducted an empirical, multi-scale field investigation from 2008–2012 to identify habitat characteristics selected by nesting western cuckoos along the LCR. Multiple logistic regression models revealed that western cuckoos selected nest sites characterized by increased densities of small, native, early successional trees measuring 8–23 cm diameter at breast height, and lower diurnal temperature compared to available habitat in restoration and natural forests. Nesting cuckoos selected sites with increased percent canopy closure, which was also important for nest success in restoration sites along the LCR. Our results show habitat components selected by nesting western cuckoos in restoration and natural riparian forests and can help guide the creation, enhancement, and management of riparian forests with habitat conditions necessary to promote nesting of western cuckoos. © 2021 The Wildlife Society. 相似文献
95.
Khoo Kelvin H. P. Sheedy Jason G. Taylor Julian D. Croser Janine S. Hayes Julie E. Sutton Tim Thompson John P. Mather Diane E. 《Molecular breeding : new strategies in plant improvement》2021,41(12):1-13
Molecular Breeding - Plant height is vital for crop yield by influencing plant architecture and resistance to lodging. Although lots of quantitative trait loci (QTLs) controlling plant height had... 相似文献
96.
Joseph Jacob Giczewska Anna Alhanti Brooke Cheema Amrita K. Handy Diane E. Mann Douglas L. Loscalzo Joseph Givertz Michael M. 《Journal of physiology and biochemistry》2021,77(2):295-304
Journal of Physiology and Biochemistry - Redox balance and methylation are crucial to homeostasis and are linked by the methionine-homocysteine cycle. We examined whether differences in methylation... 相似文献
97.
Margaret Burchinal Carollee Howes Robert Pianta Donna Bryant Diane Early Richard Clifford 《应用发育科学》2013,17(3):140-153
Publicly funded prekindergartens are programs that most states use to promote school readiness, especially of 4-year-old children at risk for academic problems due to poverty. Despite large public expenditures, these programs have not been widely evaluated. We examined 240 randomly selected pre-kindergarten programs in six states with mature programs that serve large numbers of children, and evaluated specific aspects of classroom quality and children's academic achievement in both the pre-kindergarten and kindergarten year for over 700 children. Results showed that, on average, pre-kindergarten teachers were moderately responsive and sensitive, but were less successful in engaging children in learning specific skills. Both sensitive and stimulating interactions with the teacher and the instructional quality aspects of the pre-kindergarten classroom predicted the acquisition of language, pre-academic, and social skills through the end of the kindergarten year. 相似文献
98.
Marina Stolina Brad Bolon Denise Dwyer Scot Middleton Diane Duryea Paul J. Kostenuik 《Biomarkers》2013,18(7-8):692-712
Rats with collagen-induced arthritis (CIA) were necropsied on 14 occasions from 4 days after induction to 27 days after disease onset to evaluate the kinetics of local (joint protein extracts) and systemic (serum) levels of inflammatory and pro-erosive factors. Systemic increases in α1 acid glycoprotein and KC/GRO together with systemic and local enrichment of interleukin (IL)-1β, IL-6, CCL2, transforming growth factor (TGF)-β and elevated IL-1α and IL-18 in joint extracts preceded the onset of clinical disease. Systemic upregulation of IL-1β, IL-6, TGF-β CCL2, RANKL and prostaglandin E2 (PGE2) during acute and/or chronic CIA coincided with systemic leukocytosis and a CD4+ T-cell increase in blood and spleen. In contrast, progression of joint erosions during clinical CIA was associated with intra-articular increases in IL-1α/β, IL-6, IL-18, CCL2, KC/GRO and RANKL, and a dramatic decline in osteoprotegerin (OPG). These data indicate that systemic and local events in inflammatory arthritis can be discrete processes, driven by multiple cellular and humoral mediators with distinct temporospatial profiles. 相似文献
99.
DENS: data center energy-efficient network-aware scheduling 总被引:1,自引:0,他引:1
In modern data centers, energy consumption accounts for a considerably large slice of operational expenses. The existing work in data center energy optimization is focusing only on job distribution between computing servers based on workload or thermal profiles. This paper underlines the role of communication fabric in data center energy consumption and presents a scheduling approach that combines energy efficiency and network awareness, named DENS. The DENS methodology balances the energy consumption of a data center, individual job performance, and traffic demands. The proposed approach optimizes the tradeoff between job consolidation (to minimize the amount of computing servers) and distribution of traffic patterns (to avoid hotspots in the data center network). 相似文献
100.
Frédéric Pinel Bernabé Dorronsoro Johnatan E. Pecero Pascal Bouvry Samee U. Khan 《Cluster computing》2013,16(3):421-433
The sensitivity analysis of a Cellular Genetic Algorithm (CGA) with local search is used to design a new and faster heuristic for the problem of mapping independent tasks to a distributed system (such as a computer cluster or grid) in order to minimize makespan (the time when the last task finishes). The proposed heuristic improves the previously known Min-Min heuristic. Moreover, the heuristic finds mappings of similar quality to the original CGA but in a significantly reduced runtime (1,000 faster). The proposed heuristic is evaluated across twelve different classes of scheduling instances. In addition, a proof of the energy-efficiency of the algorithm is provided. This convergence study suggests how additional energy reduction can be achieved by inserting low power computing nodes to the distributed computer system. Simulation results show that this approach reduces both energy consumption and makespan. 相似文献