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141.
Pierre L. van den Berghe Walker Connor A. H. M. Kirk‐Greene Robert Mahuta Robert Miles John Beattie 《Ethnic and racial studies》2013,36(4):484-498
Milton M. Gordon, HUMAN NATURE, CLASS AND ETHNICITY. London and New York, Oxford University Press, 1978, 302 pp., £6.50, $11.95 ($3.50 paper). June Teufel Dreyer, CHINA'S FORTY MILLIONS: MINORITY NATIONALITIES AND NATIONAL INTEGRATION IN THE PEOPLE'S REPUBLIC OF CHINA. Cambridge (Mass.) and London, Harvard University Press, 1976, 333 pp., £9.55. W. Stanford Reid (ed), THE SCOTTISH TRADITION IN CANADA. Toronto, McClelland & Stewart, 1976, xi + 324 pp., $12.55. I. H. Kawharu, MAORI LAND TENURE: STUDIES OF A CHANGING INSTITUTION. Oxford, Clarendon Press, 1977, 362 pp., £13.50. David T. Wellman, PORTRAITS OF WHITE RACISM. London, Cambridge University Press, 1977, 254 pp., £9.50 (£4.00 paper). Lucy Mair, AFRICAN KINGDOMS. Oxford, Clarendon Press, 1977, 151 pp., £3.95, (£1.95 paper). Roger Scott, NORTHERN IRELAND: THE POLITICS OF VIOLENCE. Canberra Series in Administrative Studies 2., Canberra College of Advanced Education, 1977, 84 pp., n.p. James A. Geschwender, CLASS, RACE AND WORKER INSURGENCY: THE LEAGUE OF BLACK REVOLUTIONARY WORKERS. London, Cambridge University Press, 1977, 249 pp., £8.50 (£3.50 paper). Crawford Young, THE POLITICS OF CULTURAL PLURALISM. Madison, University of Wisconsin Press, 1976. 560 pp., £13.60. D. C. R. A. Goonetilleke, DEVELOPING COUNTRIES IN BRITISH FICTION. London, Macmillan, 1977, 282 pp., £8.95. M. M. Mahood, THE COLONIAL ENCOUNTER. London, Rex Collings, 1977, 210 pp., £4.75. Brian V. Street, THE SAVAGE IN LITERATURE. London, Routledge & Kegan Paul, 1975, 207 pp., £5.75. 相似文献
142.
Justin M. Greene Jennifer J. Lhost Paul J. Hines Matthew Scarlotta Max Harris Benjamin J. Burwitz Melisa L. Budde Dawn M. Dudley Ngoc Pham Brian Cain Caitlin E. Mac Nair Madelyn K. Weiker Shelby L. O'Connor Thomas C. Friedrich David H. O'Connor 《Journal of virology》2013,87(13):7382-7392
The live attenuated simian immunodeficiency virus (SIV) SIVmac239Δnef is the most effective SIV/human immunodeficiency virus (HIV) vaccine in preclinical testing. An understanding of the mechanisms responsible for protection may provide important insights for the development of HIV vaccines. Leveraging the uniquely restricted genetic diversity of Mauritian cynomolgus macaques, we performed adoptive transfers between major histocompatibility complex (MHC)-matched animals to assess the role of cellular immunity in SIVmac239Δnef protection. We vaccinated and mock vaccinated donor macaques and then harvested between 1.25 × 109 and 3.0 × 109 mononuclear cells from multiple tissues for transfer into 12 naive recipients, followed by challenge with pathogenic SIVmac239. Fluorescently labeled donor cells were detectable for at least 7 days posttransfer and trafficked to multiple tissues, including lung, lymph nodes, and other mucosal tissues. There was no difference between recipient macaques'' peak or postpeak plasma viral loads. A very modest difference in viral loads during the chronic phase between vaccinated animal cell recipients and mock-vaccinated animal cell recipients did not reach significance (P = 0.12). Interestingly, the SIVmac239 challenge virus accumulated escape mutations more rapidly in animals that received cells from vaccinated donors. These results may suggest that adoptive transfers influenced the course of infection despite the lack of significant differences in the viral loads among animals that received cells from vaccinated and mock-vaccinated donor animals. 相似文献
143.
144.
Aquaporin-4 (AQP4) is the major water channel expressed in the central nervous system (CNS) and is primarily expressed in glial cells. Many studies have shown that AQP4 regulates the response of the CNS to insults or injury, but far less is known about the potential for AQP4 to influence synaptic plasticity or behavior. Recent studies have examined long-term potentiation (LTP), long-term depression (LTD), and behavior in AQP4 knockout (KO) and wild-type mice to gain more insight into its potential role. The results showed a selective effect of AQP4 deletion on LTP of the Schaffer collateral pathway in hippocampus using an LTP induction protocol that simulates pyramidal cell firing during theta oscillations (theta-burst stimulation; TBS). However, LTP produced by a different induction protocol was unaffected. There was also a defect in LTD after low frequency stimulation (LFS) in AQP4 KO mice. Interestingly, some slices from AQP4 KO mice exhibited LTD after TBS instead of LTP, or LTP following LFS instead of LTD. These data suggest that AQP4 and astrocytes influence the polarity of long-term synaptic plasticity (potentiation or depression). These potentially powerful roles expand the influence of AQP4 and astrocytes beyond the original suggestions related to regulation of extracellular potassium and water balance. Remarkably, AQP4 KO mice did not show deficits in basal transmission, suggesting specificity for long-term synaptic plasticity. The mechanism appears to be related to neurotrophins and specifically brain-derived neurotrophic factor (BDNF) because pharmacological blockade of neurotrophin trk receptors or scavenging ligands such as BDNF restored plasticity. The in vitro studies predicted effects in vivo of AQP4 deletion because AQP4 KO mice performed worse using a task that requires memory for the location of objects (object placement). However, performance on other hippocampal-dependent tasks was spared. The results suggest an unanticipated and selective role of AQP4 in synaptic plasticity and spatial memory, and underscore the growing appreciation of the role of glial cells in functions typically attributed to neurons. Implications for epilepsy are discussed because of the previous evidence that AQP4 influences seizures, and the role of synaptic plasticity in epileptogenesis. 相似文献
145.
Devin M. Drown Mark F. Dybdahl Richard Gomulkiewicz 《Evolution; international journal of organic evolution》2013,67(11):3290-3304
Theoretical studies have demonstrated that selection will favor increased migration when fitnesses vary both temporally and spatially, but it is far from clear how pervasive those theoretical conditions are in nature. Although consumer–resource interactions are omnipresent in nature and can generate spatial and temporal variation, it is unknown even in theory whether these dynamics favor the evolution of migration. We develop a mathematical model to address whether and how migration evolves when variability in fitness is determined at least in part by consumer–resource coevolutionary interactions. Our analyses show that such interactions can drive the evolution of migration in the resource, consumer, or both species and thus supplies a general explanation for the pervasiveness of migration. Over short time scales, we show the direction of change in migration rate is determined primarily by the state of local adaptation of the species involved: rates increase when a species is locally maladapted and decrease when locally adapted. Our results reveal that long‐term evolutionary trends in migration rates can differ dramatically depending on the strength or weakness of interspecific interactions and suggest an explanation for the evolutionary divergence of migration rates among interacting species. 相似文献
146.
Nicholas P. Greene Philip Hinchliffe Allister Crow Abdessamad AbabouColin Hughes Vassilis Koronakis 《FEBS letters》2013
Periplasmic adaptor proteins are essential components of bacterial tripartite multidrug efflux pumps. Here we report the 2.35 Å resolution crystal structure of the BesA adaptor from the spirochete Borrelia burgdorferi solved using selenomethionine derivatized protein. BesA shows the archetypal linear, flexible, multi-domain architecture evident among proteobacteria and retains the lipoyl, β-barrel and membrane-proximal domains that interact with the periplasmic domains of the inner membrane transporter. However, it lacks the α-hairpin domain shown to establish extensive coiled-coil interactions with the periplasmic entrance helices of the outer membrane-anchored TolC exit duct. This has implications for the modelling of assembled tripartite efflux pumps. 相似文献
147.
Colas Fanny Archaimbault Virginie Férard Jean-François Bouquerel Jonathan Roger Marie-Claude Devin Simon 《Hydrobiologia》2013,703(1):149-164
Freshwater ecosystems have been fragmented by the construction of large numbers of dams. In addition to disruption of ecological continuity and physical disturbance downstream, accumulation of large amounts of sediment within run-of-river reservoirs constitutes a latent ecotoxic risk to aquatic communities. To date, run-of-river reservoirs and ecotoxic risks associated with contaminated sediment to the biodiversity and functioning of such systems are little studied. Therefore, the main objective of this study was to describe macroinvertebrate assemblages, and the functioning of these systems, and to propose indicators of sediment contamination to integrate in in-situ risk assessment methodology. To identify specific assemblages of run-of-river reservoirs, we first compared macroinvertebrate assemblages and their biotrait profiles (i.e. from a database of biological and ecological traits) in reservoirs (n = 6) and associated river sites (upstream and downstream of dams). Then, we compared responses of assemblages and biotrait profiles to sediment contamination of the banks and channels of reservoirs to select the most useful spatial scale to identify sediment contamination. Nineteen indicator taxa were observed to be specifically associated with channel habitats of reservoirs. Among these, the abundance of three taxa (Tanypodinae (Diptera), Ephemerella (Ephemeroptera) and Atherix (Diptera)) revealed the effect of metal sediment contamination. “Between-reservoirs” differences in their biotrait profile were found along the contamination gradient, with a shift of communities’ composition and functionality, and an increase in functional similarity. Many traits (response traits), for example “maximum size”, “transverse distribution”, “substrate preferences”, “saprobity”, “temperature”, “resistance forms”, and “locomotion”, were specifically linked to contamination of sediments by metals. This study indicates how sediment contamination can change the structural and functional composition of run-of-river reservoir assemblages. Indicator taxa and response traits identified in this study could improve current risk assessment methodology and potentially enable prediction of the risks of contaminated sediments stored in reservoirs in downstream ecosystems. 相似文献
148.
Jiandong Zheng Xixiang Huo Yang Huai Lin Xiao Hui Jiang John Klena Carolyn M. Greene Xuesen Xing Jigui Huang Shali Liu Youxing Peng Hui Yang Jun Luo Zhibin Peng Linlin Liu Maoyi Chen Hui Chen Yuzhi Zhang Danqin Huang Xuhua Guan Luzhao Feng Faxian Zhan Dale J. Hu Jay K. Varma Hongjie Yu 《PloS one》2016,11(3)
149.
Mithun Das Jin Sha Bertha Hidalgo Stella Aslibekyan Anh N. Do Degui Zhi Dianjianyi Sun Tao Zhang Shengxu Li Wei Chen Sathanur R. Srinivasan Hemant K. Tiwari Devin Absher Jose M. Ordovas Gerald S. Berenson Donna K. Arnett Marguerite R. Irvin 《PloS one》2016,11(1)
In this study, we conducted an epigenome-wide association study of metabolic syndrome (MetS) among 846 participants of European descent in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN). DNA was isolated from CD4+ T cells and methylation at ~470,000 cytosine-phosphate-guanine dinucleotide (CpG) pairs was assayed using the Illumina Infinium HumanMethylation450 BeadChip. We modeled the percentage methylation at individual CpGs as a function of MetS using linear mixed models. A Bonferroni-corrected P-value of 1.1 x 10−7 was considered significant. Methylation at two CpG sites in CPT1A on chromosome 11 was significantly associated with MetS (P for cg00574958 = 2.6x10-14 and P for cg17058475 = 1.2x10-9). Significant associations were replicated in both European and African ancestry participants of the Bogalusa Heart Study. Our findings suggest that methylation in CPT1A is a promising epigenetic marker for MetS risk which could become useful as a treatment target in the future. 相似文献
150.
Kristin M. Kleisner Michael J. Fogarty Sally McGee Analie Barnett Paula Fratantoni Jennifer Greene Jonathan A. Hare Sean M. Lucey Christopher McGuire Jay Odell Vincent S. Saba Laurel Smith Katherine J. Weaver Malin L. Pinsky 《PloS one》2016,11(2)
Many studies illustrate variable patterns in individual species distribution shifts in response to changing temperature. However, an assemblage, a group of species that shares a common environmental niche, will likely exhibit similar responses to climate changes, and these community-level responses may have significant implications for ecosystem function. Therefore, we examine the relationship between observed shifts of species in assemblages and regional climate velocity (i.e., the rate and direction of change of temperature isotherms). The assemblages are defined in two sub-regions of the U.S. Northeast Shelf that have heterogeneous oceanography and bathymetry using four decades of bottom trawl survey data and we explore temporal changes in distribution, spatial range extent, thermal habitat area, and biomass, within assemblages. These sub-regional analyses allow the dissection of the relative roles of regional climate velocity and local physiography in shaping observed distribution shifts. We find that assemblages of species associated with shallower, warmer waters tend to shift west-southwest and to shallower waters over time, possibly towards cooler temperatures in the semi-enclosed Gulf of Maine, while species assemblages associated with relatively cooler and deeper waters shift deeper, but with little latitudinal change. Conversely, species assemblages associated with warmer and shallower water on the broad, shallow continental shelf from the Mid-Atlantic Bight to Georges Bank shift strongly northeast along latitudinal gradients with little change in depth. Shifts in depth among the southern species associated with deeper and cooler waters are more variable, although predominantly shifts are toward deeper waters. In addition, spatial expansion and contraction of species assemblages in each region corresponds to the area of suitable thermal habitat, but is inversely related to assemblage biomass. This suggests that assemblage distribution shifts in conjunction with expansion or contraction of thermal habitat acts to compress or stretch marine species assemblages, which may respectively amplify or dilute species interactions to an extent that is rarely considered. Overall, regional differences in climate change effects on the movement and extent of species assemblages hold important implications for management, mitigation, and adaptation on the U.S. Northeast Shelf. 相似文献