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141.
142.
Josie F. Gibson Grace R. Pidwill Oliver T. Carnell Bas G. J. Surewaard Daria Shamarina Joshua A. F. Sutton Charlotte Jeffery Aurlie Derr-Bobillot Cristel Archambaud Matthew K. Siggins Eric J. G. Pollitt Simon A. Johnston Pascale Serror Shiranee Sriskandan Stephen A. Renshaw Simon J. Foster 《PLoS pathogens》2021,17(9)
Staphylococcus aureus is a human commensal organism and opportunist pathogen, causing potentially fatal disease. The presence of non-pathogenic microflora or their components, at the point of infection, dramatically increases S. aureus pathogenicity, a process termed augmentation. Augmentation is associated with macrophage interaction but by a hitherto unknown mechanism. Here, we demonstrate a breadth of cross-kingdom microorganisms can augment S. aureus disease and that pathogenesis of Enterococcus faecalis can also be augmented. Co-administration of augmenting material also forms an efficacious vaccine model for S. aureus. In vitro, augmenting material protects S. aureus directly from reactive oxygen species (ROS), which correlates with in vivo studies where augmentation restores full virulence to the ROS-susceptible, attenuated mutant katA ahpC. At the cellular level, augmentation increases bacterial survival within macrophages via amelioration of ROS, leading to proliferation and escape. We have defined the molecular basis for augmentation that represents an important aspect of the initiation of infection. 相似文献
143.
Giacomo Santoiemma Damiano Fioretto Daria Corcos Nicola Mori Lorenzo Marini 《Ecological Entomology》2019,44(2):182-189
1. Spotted wing drosophila (SWD; Drosophila suzukii Matsumura, 1931) is a polyphagous invasive crop pest native of Southeast Asia able to attack a wide array of host plant species in both cultivated and natural habitats. SWD is now widespread in several mountain regions, but it is still unclear how the species moves to different elevations across the seasons, and how this depends on environmental conditions and food resources. 2. The temporal dynamics of several SWD populations were studied along elevational gradients in the Alps using a synchrony analysis. Twelve transects were selected, covering an overall elevational gradient of 2100 m. SWD abundance was monitored every 2 weeks during the growing season (from June to November 2015) when cultivated and wild hosts are potentially susceptible (i.e. fruits are ripe). 3. Spotted wing drosophila were widely distributed along all the tested elevations, revealing synchrony in population dynamics across ranges in elevation and geographic distance. Synchronised populations were observed at distances of up to 100 km at sites with similar temperatures. The high dispersal potential of the pest together with the seasonal variation in temperature are likely to be the dominant mechanisms causing the observed spatial synchrony. A factor that seemed to reduce synchrony is the large concentration of host plants (i.e. crop) in lowland agricultural landscapes. 4. The spatial synchrony in pest abundance at large spatial scale indicates that the risk of SWD outbreaks is highly dependent on drivers beyond the control of traditional field‐scale management. These findings could help in developing monitoring and predictive models of SWD population dynamics. 相似文献
144.
Kyle Nash Bastian Schiller Lorena R. R. Gianotti Thomas Baumgartner Daria Knoch 《PloS one》2013,8(11)
Recent research demonstrates that response inhibition—a core executive function—may subserve self-regulation and self-control. However, it is unclear whether response inhibition also predicts self-control in the multifaceted, high-level phenomena of social decision-making. Here we examined whether electrophysiological indices of response inhibition would predict self-control in a social context. Electroencephalography was recorded as participants completed a widely used Go/NoGo task (the cued Continuous Performance Test). Participants then interacted with a partner in an economic exchange game that requires self-control. Results demonstrated that greater NoGo-Anteriorization and larger NoGo-P300 peak amplitudes—two established electrophysiological indices of response inhibition—both predicted more self-control in this social game. These findings support continued integration of executive function and self-regulation and help extend prior research into social decision-making processes. 相似文献
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Giovanna Bonadonna Valeria Torti Chiara De Gregorio Daria Valente Rose Marie Randrianarison Luca Pozzi Marco Gamba Cristina Giacoma 《American journal of primatology》2019,81(6)
Monogamy is a rare strategy among mammals but relatively common among primates. The study of the evolution of monogamy in mammals and primates is lacking empirical studies that assess the relationship between a pair‐living social organization and genetic monogamy. Sexual or genetic monogamy can only be assessed by performing molecular analyses and investigating rates of extra‐pair paternity (EPP). Studying the occurrence of EPP can provide valuable insights into reproductive strategies and their adaptive value. The indri is a pair‐living primate that lives in stable groups. Their social units are composed of the reproductive pair and up to four more individuals, but extra‐pair copulation (EPC) can occur. This raises the question of whether this event may or may not lead to EPP. Here, we investigated whether a pair‐living social organization corresponds to genetic monogamy in indris (Indri indri). We analyzed the paternity of 12 offspring from seven pairs using a set of six microsatellite loci on fecal samples (mean number of alleles 11.7 ± 1.8 (mean ± standard deviation). We found that in 92% of cases the genetic profile of the offspring matched the paired male of the group for all the loci considered. In the only case of paternity mismatch, the paternity assignment remained inconclusive. Our results show that I. indri genetic monogamy is the norm and supports the hypothesis that pair‐living social organization is associated with low EPP rate. Also, our results are in contrast with the hypothesis of infertility as a reason to engage in EPC for this species. 相似文献
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Alexandra A. Korotaeva Elena V. Samoilova Daria A. Chepurnova Irina V. Zhitareva Yulia A. Shuvalova Nina V. Prokazova 《Biomarkers》2018,23(6):527-532
Purpose: Recent studies indicate that the effects of interleukin 6 (IL-6) realized via soluble IL-6 receptor (sIL-6R) facilitate the development of various pathological processes. Soluble gp130 (sgp130) is a naturally occurring inhibitor of signal transduction via this pathway. In this study, we assessed the relationship between circulating levels of IL-6, sIL-6R and sgp130 and severity of coronary atherosclerosis in patients with stable coronary artery disease (CAD).Methods: Plasma levels of IL-6, sIL-6R and sgp130 were measured in patients with atherosclerotic coronary lesions (n?=?128, group 1) and with intact coronary arteries (n?=?48, group 2). The severity of coronary atherosclerosis was evaluated by the number of affected arteries and by Gensini Score index.Results: Circulating IL-6 levels in group 1 were significantly higher than those in group 2. The levels of sIL-6R did not differ considerably in both the groups. The levels of sgp130 in group 1 were significantly lower than in group 2. A negative correlation has been revealed between sgp130 levels and the number of affected coronary arteries and Gensini Score index.Conclusions: Serum concentration of sgp130 in patients with stable CAD is inversely related to severity of coronary damage. Low sgp130 level may serve as an additional indicator of coronary atherosclerosis severity. 相似文献
149.
Nailya R. Almyasheva Maria I. Shuktueva Daria A. Petrova Dmitry S. Kopitsyn Mikhail S. Kotelev Vladimir A. Vinokurov Andrei A. Novikov 《Mycoscience》2018,59(2):147-152
Methanolysis of sunflower oil catalyzed by immobilized Aspergillus niger mycelium was studied in a packed-bed reactor. The optimal cultivation parameters for A. niger were determined using full factorial and steepest ascent experimental designs. Sunflower oil, yeast extract and soybean meal were selected as the best carbon and nitrogen sources and were used in the subsequent experiments. Intracellular lipase activity and cell mass concentration were respectively 3.2 and 2.4 times greater and cultivation period decreased by 24 h compared with the initial medium. The optimum values of these most significant parameters were as follows: sunflower oil (13.2 g/L), yeast extract (6.2 g/L), soybean meal (7.4 g/L) and incubation period (72 h) at 30 °C. With A. niger biocatalyst grown in optimized conditions, the biodiesel fuel yield reached 23.1% after sixth pass of recycled reaction mixture through the reactor. 相似文献
150.
The role of host phenology in determining the incidence of an insect sexually transmitted infection 下载免费PDF全文
Daria Pastok Mary‐Jo Hoare Jon J. Ryder Mike Boots Rob J. Knell David Atkinson Gregory D. D. Hurst 《Oikos》2016,125(5):636-643
Changes in the timing of life history events within the year alter the degree to which the activity patterns of different species coincide, making the dynamics of interspecific interactions sensitive to the phenology of the interacting parties. For parasites, the availability of suitable hosts to infect represents a crucial determinant of dynamics, and changes in the host (and parasite) phenology may thus alter disease epidemiology and the conditions for disease maintenance. We tested the hypothesis that the incidence of a sexually transmitted mite infection, Coccipolipus hippodamiae, in Adalia bipunctata ladybird beetles in Sweden was determined by host phenology, namely presence/absence of sexual contact between cohorts of the host. We observed that the pattern of mite presence/absence across Swedish A. bipunctata populations was highly reproducible between years, implying a persistent biological/ecological basis underlying the incidence. Further, ladybirds from populations where the mite was absent were able to acquire mites during copulation, develop a mite infection, and transmit infection onward, indicating an ecological (rather than biological) driver of mite incidence. Observations of ladybird phenology in natural populations provided evidence of sexual contact between overwintered and new cohort adults in populations where the mite was present. In contrast, new cohort ladybirds in the two northern Swedish populations where the mite was not present had not had sexual contact with the overwintered generation, creating a ‘hard stop’ to mite transmission. We conclude that variation in host phenology may be an important driver of the incidence of sexually transmitted infections (STIs) by determining the presence/absence of sexual contact between generations. More generally, we hypothesize that sensitivity to variation in host phenology will be highest for parasites like STIs that infect one host species, one host life stage and are directly transmitted on contact between host individuals. 相似文献