全文获取类型
收费全文 | 361篇 |
免费 | 34篇 |
出版年
2021年 | 4篇 |
2019年 | 4篇 |
2018年 | 4篇 |
2016年 | 6篇 |
2015年 | 5篇 |
2014年 | 11篇 |
2013年 | 18篇 |
2012年 | 12篇 |
2011年 | 14篇 |
2010年 | 10篇 |
2009年 | 4篇 |
2008年 | 7篇 |
2007年 | 11篇 |
2006年 | 10篇 |
2005年 | 6篇 |
2004年 | 7篇 |
2003年 | 14篇 |
2002年 | 8篇 |
2001年 | 13篇 |
2000年 | 14篇 |
1999年 | 7篇 |
1995年 | 6篇 |
1992年 | 4篇 |
1991年 | 5篇 |
1989年 | 5篇 |
1988年 | 3篇 |
1987年 | 5篇 |
1986年 | 3篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1980年 | 3篇 |
1979年 | 8篇 |
1978年 | 3篇 |
1976年 | 3篇 |
1975年 | 9篇 |
1974年 | 7篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1969年 | 5篇 |
1961年 | 4篇 |
1950年 | 3篇 |
1942年 | 3篇 |
1940年 | 4篇 |
1938年 | 3篇 |
1936年 | 18篇 |
1933年 | 13篇 |
1932年 | 8篇 |
1931年 | 11篇 |
1929年 | 4篇 |
排序方式: 共有395条查询结果,搜索用时 15 毫秒
91.
92.
93.
94.
95.
96.
D Tarin J E Price M G Kettlewell R G Souter A C Vass B Crossley 《BMJ (Clinical research ed.)》1984,288(6419):749-751
Fourteen patients with inoperable cancer treated with peritoneovenous shunts for malignant ascites were studied post mortem. Clinical observations and findings at necropsy indicated that peritoneovenous shunting does not result in the establishment of clinically important haematogenous metastases and that metastases do not necessarily develop even when large numbers of viable tumour cells regularly enter the blood. Peritoneovenous shunting provides a unique opportunity for collecting data on the spread of tumours in man. 相似文献
97.
W. F. LOOMIS C. KLEIN PH. BRACKET 《Differentiation; research in biological diversity》1979,12(1-3):83-89
Following the initiation of development, amoebae of Dictyostelium discoideum aggregate chemotactically toward cyclic AMP (cAMP). Adenyl cyclase, cAMP phosphodiesterase, and cAMP binding sites all increase 20–40 fold during the first few hours of development. It has been shown that addition of 1 mM EDTA and 5 mM MgCl2 accelerates the aggregation process. Likewise, the calcium ionophore, A23187, leads to precocious aggregation while 4 × 10−5 M progesterone considerably delays it These treatments have now been shown to result in increased accumulation of adenyl cyclase in the case of EDTA and Mg2+ or the ionophore and greatly decreased accumulation in the case of the steroid.
Treatment with EDTA and Mg2+ or the ionophore has been shown not only to accelerate aggregation in wild-type amoebae but to overcome complete blocks to aggregation in certain mutant strains. We have found that addition of Mn2+ will also permit aggregation of mutant cells otherwise unable to aggregate. This divalent ion, unlike EDTA and Mg2+ or the ionophore, was shown to directly stimulate adenyl cyclase. Calcium ions were also found to affect the enzyme such that at Ca2+ concentrations found within the cells the great majority of the activity is inhibited. Manganese ions can overcome the inhibition by Ca2+ .
These findings show that conditions which stimulate aggregation result in increased activity of adenyl cyclase either by increased accumulation of the enzyme or by increased activity of the available enzyme, and support the proposed central role of adenyl cyclase in aggregation. 相似文献
Treatment with EDTA and Mg
These findings show that conditions which stimulate aggregation result in increased activity of adenyl cyclase either by increased accumulation of the enzyme or by increased activity of the available enzyme, and support the proposed central role of adenyl cyclase in aggregation. 相似文献
98.
99.
100.
Sex effects on behaviour were investigated by repeatedly mating the same male and female Drosophila melanogaster. Male influence is mainly on percentage wing vibration while females largely determine wing vibration duration and bout number. This courtship pattern is stable across matings involving the same individuals. 相似文献