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排序方式: 共有1177条查询结果,搜索用时 31 毫秒
61.
Genevieve E. Davis Mark F. Baumgartner Peter J. Corkeron Joel Bell Catherine Berchok Julianne M. Bonnell Jacqueline Bort Thornton Solange Brault Gary A. Buchanan Danielle M. Cholewiak Christopher W. Clark Julien Delarue Leila T. Hatch Holger Klinck Scott D. Kraus Bruce Martin David K. Mellinger Hilary Moors‐Murphy Sharon Nieukirk Douglas P. Nowacek Susan E. Parks Dawn Parry Nicole Pegg Andrew J. Read Aaron N. Rice Denise Risch Alyssa Scott Melissa S. Soldevilla Kathleen M. Stafford Joy E. Stanistreet Erin Summers Sean Todd Sofie M. Van Parijs 《Global Change Biology》2020,26(9):4812-4840
Six baleen whale species are found in the temperate western North Atlantic Ocean, with limited information existing on the distribution and movement patterns for most. There is mounting evidence of distributional shifts in many species, including marine mammals, likely because of climate‐driven changes in ocean temperature and circulation. Previous acoustic studies examined the occurrence of minke (Balaenoptera acutorostrata) and North Atlantic right whales (NARW; Eubalaena glacialis). This study assesses the acoustic presence of humpback (Megaptera novaeangliae), sei (B. borealis), fin (B. physalus), and blue whales (B. musculus) over a decade, based on daily detections of their vocalizations. Data collected from 2004 to 2014 on 281 bottom‐mounted recorders, totaling 35,033 days, were processed using automated detection software and screened for each species' presence. A published study on NARW acoustics revealed significant changes in occurrence patterns between the periods of 2004–2010 and 2011–2014; therefore, these same time periods were examined here. All four species were present from the Southeast United States to Greenland; humpback whales were also present in the Caribbean. All species occurred throughout all regions in the winter, suggesting that baleen whales are widely distributed during these months. Each of the species showed significant changes in acoustic occurrence after 2010. Similar to NARWs, sei whales had higher acoustic occurrence in mid‐Atlantic regions after 2010. Fin, blue, and sei whales were more frequently detected in the northern latitudes of the study area after 2010. Despite this general northward shift, all four species were detected less on the Scotian Shelf area after 2010, matching documented shifts in prey availability in this region. A decade of acoustic observations have shown important distributional changes over the range of baleen whales, mirroring known climatic shifts and identifying new habitats that will require further protection from anthropogenic threats like fixed fishing gear, shipping, and noise pollution. 相似文献
62.
Rebecca E. Koch Katherine L. Buchanan Stefania Casagrande Ondi Crino Damian K. Dowling Geoffrey E. Hill Wendy R. Hood Matthew McKenzie Mylene M. Mariette Daniel W.A. Noble Alexandra Pavlova Frank Seebacher Paul Sunnucks Eve Udino Craig R. White Karine Salin Antoine Stier 《Trends in ecology & evolution》2021,36(4):321-332
63.
Hung-Hsin Chen Douglas M. Shaw Lauren E. Petty Misa Graff Ryan J. Bohlender Hannah G. Polikowsky Xue Zhong Daeeun Kim Victoria L. Buchanan Michael H. Preuss Megan M. Shuey Ruth J.F. Loos Chad D. Huff Nancy J. Cox Julie A. Bastarache Lisa Bastarache Kari E. North Jennifer E. Below 《American journal of human genetics》2021,108(1):194-201
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65.
Aurélie Crabbé Sheila M. Nielsen-Preiss Christine M. Woolley Jennifer Barrila Kent Buchanan James McCracken Diane O. Inglis Stephen C. Searles Mayra A. Nelman-Gonzalez C. Mark Ott James W. Wilson Duane L. Pierson Heidemarie M. Stefanyshyn-Piper Linda E. Hyman Cheryl A. Nickerson 《PloS one》2013,8(12)
66.
Andrew Buchanan Veronica Clementel Rob Woods Nicholas Harn Michael A Bowen Wenjun Mo Bojana Popovic Steven M. Bishop William Dall’Acqua Ralph Minter Lutz Jermutus Vahe Bedian 《MABS-AUSTIN》2013,5(2):255-262
Antibodies can undergo a variety of covalent and non-covalent degradation reactions that have adverse effects on efficacy, safety, manufacture and storage. We had identified an antibody to Angiopoietin 2 (Ang2 mAb) that neutralizes Ang2 binding to its receptor in vitro and inhibits tumor growth in vivo. Despite favorable pharmacological activity, the Ang2 mAb preparations were heterogeneous, aggregated rapidly and were poorly expressed. Here, we report the engineering of the antibody variable and constant domains to generate an antibody with reduced propensity to aggregate, enhanced homogeneity, 11°C elevated Tm, 26-fold improved level of expression and retained activity. The engineered molecule, MEDI-3617, is now compatible with the large scale material supply required for clinical trials and is currently being evaluated in Phase 1 in cancer patients. This is the first report to describe the stability engineering of a therapeutic antibody addressing non canonical cysteine residues and the design strategy reported here is generally applicable to other therapeutic antibodies and proteins. 相似文献
67.
Yu-Tao Xiang Robert W. Buchanan Gabor S. Ungvari Helen F. K. Chiu Kelly Y. C. Lai You-Hong Li Tian-Mei Si Chuan-Yue Wang Edwin H. M. Lee Yan-Ling He Shu-Yu Yang Mian-Yoon Chong Ee-Heok Kua Senta Fujii Kang Sim Michael K. H. Yong Jitendra K. Trivedi Eun-Kee Chung Pichet Udomratn Kok-Yoon Chee Norman Sartorius Chay-Hoon Tan Naotaka Shinfuku 《PloS one》2013,8(6)
68.
Ann Buchanan Josué Díaz-Delgado Gaya Balamayooran Maritza Anguiano Kátia Groch Lana Krol 《Journal of medical primatology》2020,49(6):341-343
Hematopoietic neoplasia other than lymphoma and leukemia is uncommon among non-human primates. Herein, we provide the first evidence of occurrence of leukemic histiocytic sarcoma in a captive common squirrel monkey with Saimiriine Gammaherpesvirus 2 (Rhadinovirus), Saimiri sciureus lymphocryptovirus 2 (Lymphocryptovirus), and Squirrel monkey retrovirus (β-Retrovirus) coinfection. 相似文献
69.
70.
Raoul F. H. Ribot Mathew L. Berg Katherine L. Buchanan Andrew T. D. Bennett 《Journal of avian biology》2013,44(4):399-407
Learned vocal signals could be important in the formation of prezygotic isolation between two hybridising taxa. This study examined whether vocal variation in the parrot Platycercus elegans facilitates the separation of individuals from two subspecies, P. e. elegans (CR) and P. e. flaveolus (YR). CR and YR have very different plumage coloration, respectively deep crimson and pale yellow, but hybridise where they meet creating an intermediate population (WS). In a factorial design playback experiment, we conducted 108 playback trials on three focal populations (YR, WS, CR), in and around this area of hybridisation, to test if they respond differently to contact calls from their own or another population. We also analysed whether differences in acoustic variables of the stimulus calls predicted the response to the call. We did not find any indication that individuals from the three focal populations responded differently to calls sampled from their own or another subspecies. We did find an effect of two of the five acoustic variables that we used to describe and classify contact calls from the three source populations. Specifically, duration of the stimulus call positively affected the response from individuals from WS and negatively the response from CR, and CR responded more to stimulus calls with a lower peak frequency. Overall, we found no indication that acoustic variation in contact calls on a subspecies level is involved in maintaining plumage colour differences between P. e. elegans and P. e. flaveolus subspecies. 相似文献