排序方式: 共有139条查询结果,搜索用时 359 毫秒
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Bahareh Varzandian Mostafa Ghaderi-Zefrehei Mostafa Sayyadi Vahideh Taghadosi Sara Varzandian 《Animal biotechnology》2017,28(4):294-300
Cytokines are immune regulators that play an essential role in regulating immune response against various infections. The present study focused on the possible association between the expression level of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows in Fars province, Iran, using a quantitative real-time PCR assay. The experimental groups were categorized according to the number of calvings. The expression level of IL-10 was significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones. Concomitant to increasing the number of calving, a numerical elevation in the expression of IL-10 in blood was observed (P?0.05). The bioinformatics analysis of IL-10 gene revealed the promoter, exon-intron regions, and nucleosome profile. The nucleosome occupancy site was finally predicted using NUPOP software. Our result indicated that the promoter was not exactly placed in the nucleosome region, which was finally aimed to predict the position and expression of IL-10 gene in the mastitic cows. 相似文献
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Mohammad Panahi Bahareh Rahimi Golbarg Rahimi Teck Yew Low Neda Saraygord-Afshari Effat Alizadeh 《Journal of cellular physiology》2020,235(10):6462-6495
Mesenchymal stem cells (MSCs) are earmarked as perfect candidates for cell therapy and tissue engineering due to their capacity to differentiate into different cell types. However, their potential for application in regenerative medicine declines when the levels of the reactive oxygen and nitrogen species (RONS) increase from the physiological levels, a phenomenon which is at least inevitable in ex vivo cultures and air-exposed damaged tissues. Increased levels of RONS can alter the patterns of osteogenic and adipogenic differentiation and inhibit proliferation, as well. Besides, oxidative stress enhances senescence and cell death, thus lowering the success rates of the MSC engraftment. Hence, in this review, we have selected some representatives of antioxidants and newly emerged nano antioxidants in three main categories, including chemical compounds, biometabolites, and protein precursors/proteins, which are proved to be effective in the treatment of MSCs. We will focus on how antioxidants can be applied to optimize the clinical usage of the MSCs and their associated signaling pathways. We have also reviewed several paralleled properties of some antioxidants and nano antioxidants which can be simultaneously used in real-time imaging, scaffolding techniques, and other applications in addition to their primary antioxidative function. 相似文献
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Pezeshk Samaneh Ojagh Seyed Mahdi Rezaei Masoud Shabanpour Bahareh 《Probiotics and antimicrobial proteins》2019,11(3):1015-1022
Probiotics and Antimicrobial Proteins - In this study, yellowfin tuna (Thunnus albacores) viscera were hydrolyzed with protamex to obtain hydrolysate that is separated by a membrane ultrafiltration... 相似文献
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Bahareh Pourjafari Hamid Pour-Jafari Marzieh Farimani Safieh Ghahramani Ebrahim Kamrani Saleh 《Indian journal of human genetics》2012,18(2):250-253
One of the main genetic causes involve in the pathogenesis of recurrent abortion is parental chromosomal abnormalities. The central concept in genetic counseling with such families is to estimate the probability of recurrence of unfavorable pregnancy outcomes. The main questions that consultants usually ask are: Why did this happen? What is the risk to be done again?Our cases were two families with repeated miscarriage. The pedigrees were drawn, the chromosomes of couples were studied, and estimation for recurrent risk was done. We tried to answer those two main questions and clear the results for them.Parental chromosome abnormalities were founded after karyotyping with GTG technique at 450 band resolution, revealing 46 chromosomes with balanced translocation of autosomes in one of the partner in both families. Recurrent risk was estimated as “high” for their future pregnancies in each family.Couples in which one partner is the carrier of such balanced translocation have increased risks of infertility, recurrent abortion, and delivery of chromosomally abnormal offspring. Genetic counseling of such couples, therefore, presents a unique challenge and should be considered in dealing with such families. 相似文献
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Maedeh Masoumipour Bahareh Abbaspanah Seyed Hadi Mousavi 《Cell biology international》2021,45(10):2031-2044
Extracellular vesicles (EVs) either as endocytic or plasma membrane-emerged vesicles play pivotal role in cell-to-cell communication. Due to the bioactive molecules transformation, lymphoma cell-derived vesicles can alter a recipient cell's function and contribute to signal transduction and drug resistance. These vesicles by acting not only in tumor cells but also in tumor-associated cells have important roles in tumor growth and invasion. On the other hand, the total protein level of circulating exosomes reveals the disease stage, tumor burden, response to therapy, and survival. In residual disease, leukemic blasts are undetectable in the bone marrow by conventional methods but exosomal proteins are elevated significantly. In this manner, new methods for measuring exosomes and exosomal components are required. In this review, we try to reveal the concealed role of EVs in hematological malignancies besides therapeutic potentials. 相似文献