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排序方式: 共有232条查询结果,搜索用时 46 毫秒
101.
Kazemi T Asgarian-Omran H Memarian A Shabani M Sharifian RA Vossough P Ansaripour B Rabbani H Shokri F 《Cancer immunology, immunotherapy : CII》2009,58(6):989-996
Recent studies have demonstrated expression of Fc receptor-like (FCRL) molecules, a newly identified family with preferential
B-cell lineage expression, in some chronic B-cell leukemias with possible implication for classification and/or targeted immunotherapy.
In this study, the expression pattern of FCRL1-5 genes was studied in 73 Iranian ALL patients and 35 normal subjects using
semi-quantitative RT-PCR method. FCRL protein expression was also investigated by flow cytometry. Our results indicate significant
down-regulation of all FCRL genes in ALL compared to normal subjects. Although, FCRL mRNA expression was almost exclusively
confined to normal isolated B-cells compared to T-cells, but these genes were similarly expressed in B-ALL, T-ALL and different
B-ALL immunophenotypic subtypes. Surface protein expression of FCRL1, 2, 4, and 5 molecules in 10 ALL and 5 normal samples
confirmed the PCR results. Expression profile of FCRL molecules in different subtypes of ALL argues against their potential
implication as suitable targets for classification and/or immunotherapy of ALL.
T. Kazemi, H. Asgarian-Omran and A. Memarian have contributed equally to this study. 相似文献
102.
Majid Safa Ahmad Kazemi Hamid Zand Azita Azarkeivan Farhad Zaker Parisa Hayat 《Apoptosis : an international journal on programmed cell death》2010,15(2):196-203
Exposure of cells to chemotherapeutic drug doxorubicin, a DNA-damaging agent, induces an increase in the levels and activity
of the wild-type p53 protein. Less well appreciated was the effect of cAMP levels on posttranslational modifications of p53
in response to doxorubicin. Here we show that elevation of cAMP in pre-B acute lymphoblastic leukemia NALM-6 cells significantly
attenuated phosphorylation state of p53 at Ser6, Ser9, Ser15, Ser20, Ser37, Ser46 and Ser392 upon exposure to doxorubicin.
Increased cAMP levels also shifted the ratio of the death promoter to death repressor genes via alteration of Bcl-2 and Bax
proteins expression. In conclusion, our results suggest that activation of cAMP-signaling system may repress p53-dependent
apoptosis in malignant cells exposed to doxorubicin. 相似文献
103.
Voltage gating of VDAC is regulated by nonlamellar lipids of mitochondrial membranes 总被引:1,自引:0,他引:1
Rostovtseva TK Kazemi N Weinrich M Bezrukov SM 《The Journal of biological chemistry》2006,281(49):37496-37506
Evidence is accumulating that lipids play important roles in permeabilization of the mitochondria outer membrane (MOM) at the early stage of apoptosis. Lamellar phosphatidylcholine (PC) and nonlamellar phosphatidylethanolamine (PE) lipids are the major membrane components of the MOM. Cardiolipin (CL), the characteristic lipid from the mitochondrial inner membrane, is another nonlamellar lipid recently shown to play a role in MOM permeabilization. We investigate the effect of these three key lipids on the gating properties of the voltage-dependent anion channel (VDAC), the major channel in MOM. We find that PE induces voltage asymmetry in VDAC current-voltage characteristics by promoting channel closure at cis negative applied potentials. Significant asymmetry is also induced by CL. The observed differences in VDAC behavior in PC and PE membranes cannot be explained by differences in the insertion orientation of VDAC in these membranes. Rather, it is clear that the two nonlamellar lipids affect VDAC gating. Using gramicidin A channels as a tool to probe bilayer mechanics, we show that VDAC channels are much more sensitive to the presence of CL than could be expected from the experiments with gramicidin channels. We suggest that this is due to the preferential insertion of VDAC into CL-rich domains. We propose that the specific lipid composition of the mitochondria outer membrane and/or of contact sites might influence MOM permeability by regulating VDAC gating. 相似文献
104.
105.
106.
Wang S Raven JF Baltzis D Kazemi S Brunet DV Hatzoglou M Tremblay ML Koromilas AE 《The Journal of biological chemistry》2006,281(14):9439-9449
107.
108.
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability 下载免费PDF全文
Robert F Kapp LD Khan SN Acker MG Kolitz S Kazemi S Kaufman RJ Merrick WC Koromilas AE Lorsch JR Pelletier J 《Molecular biology of the cell》2006,17(11):4632-4644
A cornerstone of the antiviral interferon response is phosphorylation of eukaryotic initiation factor (eIF)2alpha. This limits the availability of eIF2.GTP.Met-tRNA(i)(Met) ternary complexes, reduces formation of 43S preinitiation complexes, and blocks viral (and most cellular) mRNA translation. However, many viruses have developed counterstrategies that circumvent this cellular response. Herein, we characterize a novel class of translation initiation inhibitors that block ternary complex formation and prevent the assembly of 43S preinitiation complexes. We find that translation driven by the HCV IRES is refractory to inhibition by these compounds at concentrations that effectively block cap-dependent translation in vitro and in vivo. Analysis of initiation complexes formed on the HCV IRES in the presence of inhibitor indicates that eIF2alpha and Met-tRNA(i)(Met) are present, defining a tactic used by HCV to evade part of the antiviral interferon response. 相似文献
109.
110.
Mansoureh Vatanshenassan Mehdi Mohebali Bahram Kazemi Mostafa Rezaeian 《Experimental parasitology》2010,126(2):187-190
Trichomonas vaginalis is the agent of a highly prevalent sexually transmitted disease that leads to vaginitis, urethritis, ectocervicitis and has been associated with human immunodeficiency virus (HIV). Detection of T. vaginalis based on wet-mount microscopy and culture methods is insensitive and time consuming, respectively. Thus the quest for reliable PCR techniques of T. vaginalis in vaginal discharge and urine sample is more importance. In this study, 500 urine and vaginal-discharge samples were collected from women referred to Sexual Transmitted Disease Clinic of Mirzakuchakkhan Hospital in Tehran, Iran between May 2008 and March 2009. Wet-mount and culture methods were done on the vaginal discharges, and PCR assay targeting cysteine proteinase 4 (CP4) was performed on the urine samples. The present study demonstrated 16 (3.2%) of patients were infected with T. vaginalis using culture and wet-mount, whereas PCR assay using CP4 could detect 12 (2.4%) positivity. Sensitivity and specificity of urine PCR assay compared to culture were 80% (95% CI, 54-96) and 99.6% (95% CI, 98.96-100), respectively. These results indicate that using urine-based detection method for T. vaginalis may not be appropriate in women. 相似文献